{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:42:46Z","timestamp":1767850966770,"version":"3.49.0"},"reference-count":107,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Proyecto Canon Minero","award":["VRIIP0056-21"],"award-info":[{"award-number":["VRIIP0056-21"]}]},{"name":"Fondo Interno VRII-UNAP","award":["VRIIP0056-21"],"award-info":[{"award-number":["VRIIP0056-21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Blueberries (Vaccinium corymbosum L.) are cultivated worldwide and are among the best dietary sources of bioactive compounds with beneficial health effects. This study aimed to investigate the components of Peruvian blueberry using high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry (HPLC\u2013ESI\u2013QTOF\u2013MS\/MS), identifying 11 compounds. Furthermore, we assessed in vitro the antioxidant activity and in vivo the antidepressant effect using a rat model and protective effect on lipid peroxidation (in the serum, brain, liver, and stomach). We also conducted molecular docking simulations with proteins involved in oxidative stress and depression for the identified compounds. Antioxidant activity was assessed by measuring total phenolic and flavonoid contents, as well as using 1,1-diphenyl-2-picrylhydrazin (DPPH), 2,2\u2032-azino-bis-(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS\u2022+), and ferric-reducing antioxidant power (FRAP) assays. Peruvian blueberries demonstrated higher antioxidant activity than Vaccinium corymbosum fruits from Chile, Brazil, the United States, Turkey, Portugal, and China. The results showed that oral administration of Peruvian blueberries (10 and 20 mg\/kg) for 28 days significantly (p &lt; 0.001) increased swimming and reduced immobility in the forced swimming test (FST). Additionally, at doses of 40 and 80 mg\/kg, oxidative stress was reduced in vivo (p &lt; 0.001) by decreasing lipid peroxidation in brain, liver, stomach, and serum. Molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET) predictions were performed. In the molecular docking studies, quercitrin and 3,5-di-O-caffeoylquinic acid showed the best docking scores for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, superoxide dismutase, and xanthine oxidase; while 3,5-dicaffeoylquinic acid methyl ester and caffeoyl coumaroylquinic acid had the best docking scores for monoamine oxidase and serotonin receptor 5-HT2. In summary, our results suggest that the antidepressant and protective effects against lipid peroxidation might be related to the antioxidant activity of Peruvian Vaccinium corymbosum L.<\/jats:p>","DOI":"10.3390\/plants13121643","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:02:26Z","timestamp":1718352146000},"page":"1643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chemical Composition, Antioxidant Activities, Antidepressant Effect, and Lipid Peroxidation of Peruvian Blueberry: Molecular Docking Studies on Targets Involved in Oxidative Stress and Depression"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-0654","authenticated-orcid":false,"given":"Iv\u00e1n M.","family":"Quispe-D\u00edaz","sequence":"first","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-7957","authenticated-orcid":false,"given":"Roberto O.","family":"Yba\u00f1ez-Julca","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-1115","authenticated-orcid":false,"given":"Ricardo","family":"Pino-R\u00edos","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Medicinal, Qu\u00edmica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"},{"name":"Instituto de Qu\u00edmica Medicinal, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1552-2586","authenticated-orcid":false,"given":"Jos\u00e9 D.","family":"Quispe-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-2121","authenticated-orcid":false,"given":"Daniel","family":"Asunci\u00f3n-Alvarez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mantilla-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-3744","authenticated-orcid":false,"given":"Roger A.","family":"Rengifo-Penadillos","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-6394","authenticated-orcid":false,"given":"Edison","family":"V\u00e1squez-Corales","sequence":"additional","affiliation":[{"name":"Escuela de Farmacia y Bioqu\u00edmica, Universidad Cat\u00f3lica Los \u00c1ngeles de Chimbote, Chimbote 02801, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo D. D. G.","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Trujillo 13011, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-7612","authenticated-orcid":false,"given":"Wilfredo O.","family":"Guti\u00e9rrez-Alvarado","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de la Amazon\u00eda Peruana, Iquitos 16001, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8562-0078","authenticated-orcid":false,"given":"Julio","family":"Benites","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Medicinal, Qu\u00edmica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"},{"name":"Instituto de Qu\u00edmica Medicinal, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Akimova, S., Radzhabov, A., Esaulko, A., Samoshenkov, E., Nechiporenko, I., Kazakov, P., Voskoboinikov, Y., Matsneva, A., Zubkov, A., and Aisanov, T. 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