{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:15:48Z","timestamp":1760145348158,"version":"build-2065373602"},"reference-count":114,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese FCT","doi-asserted-by":"publisher","award":["UIDB\/00102\/2020","UIDP\/00102\/2020","UIDB\/04539\/2020","UIDP\/04539\/2020","LA\/P\/0058\/2020","PD21-00003"],"award-info":[{"award-number":["UIDB\/00102\/2020","UIDP\/00102\/2020","UIDB\/04539\/2020","UIDP\/04539\/2020","LA\/P\/0058\/2020","PD21-00003"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDB\/00102\/2020","UIDP\/00102\/2020","UIDB\/04539\/2020","UIDP\/04539\/2020","LA\/P\/0058\/2020","PD21-00003"],"award-info":[{"award-number":["UIDB\/00102\/2020","UIDP\/00102\/2020","UIDB\/04539\/2020","UIDP\/04539\/2020","LA\/P\/0058\/2020","PD21-00003"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"La Caixa Foundation","award":["UIDB\/00102\/2020","UIDP\/00102\/2020","UIDB\/04539\/2020","UIDP\/04539\/2020","LA\/P\/0058\/2020","PD21-00003"],"award-info":[{"award-number":["UIDB\/00102\/2020","UIDP\/00102\/2020","UIDB\/04539\/2020","UIDP\/04539\/2020","LA\/P\/0058\/2020","PD21-00003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The infusion of Santolina impressa, an endemic Portuguese plant, is traditionally used to treat various infections and disorders. This study aimed to assess its chemical profile by HPLC-DAD-ESI-MSn and validate its anti-inflammatory potential. In addition, the antioxidant capacity and effects on wound healing, lipogenesis, melanogenesis, and cellular senescence, all processes in which a dysregulated inflammatory response plays a pivotal role, were unveiled. The anti-inflammatory potential was assessed in lipopolysaccharide (LPS)-stimulated macrophages, cell migration was determined using a scratch wound assay, lipogenesis was assessed on T0901317-stimulated keratinocytes and melanogenesis on 3-isobutyl-1-methylxanthine (IBMX)-activated melanocytes. Etoposide was used to induce senescence in fibroblasts. Our results point out a chemical composition predominantly characterized by dicaffeoylquinic acids and low amounts of flavonols. Regarding the infusion\u2019s bioactive potential, an anti-inflammatory effect was evident through a decrease in nitric oxide production and inducible nitric oxide synthase and pro-interleukin-1\u03b2 protein levels. Moreover, a decrease in fibroblast migration was observed, as well as an inhibition in both intracellular lipid accumulation and melanogenesis. Furthermore, the infusion decreased senescence-associated \u03b2-galactosidase activity, \u03b3H2AX nuclear accumulation and both p53 and p21 protein levels. Overall, this study confirms the traditional uses of S. impressa and ascribes additional properties of interest in the pharmaceutical and dermocosmetics industries.<\/jats:p>","DOI":"10.3390\/plants13141943","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T15:17:06Z","timestamp":1721056626000},"page":"1943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking the Bioactive Potential and Exploring Novel Applications for Portuguese Endemic Santolina impressa"],"prefix":"10.3390","volume":"13","author":[{"given":"Jorge M.","family":"Alves-Silva","sequence":"first","affiliation":[{"name":"Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-3532","authenticated-orcid":false,"given":"S\u00f3nia","family":"Pedreiro","sequence":"additional","affiliation":[{"name":"Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), University of Porto, 4099-002 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4128-9010","authenticated-orcid":false,"given":"M\u00f3nica","family":"Zuzarte","sequence":"additional","affiliation":[{"name":"Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6754","authenticated-orcid":false,"given":"Maria Teresa","family":"Cruz","sequence":"additional","affiliation":[{"name":"Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Univ Coimbra Center for Neuroscience and Cell Biology (CNC-UC), Faculty of Medicine, Rua Larga, 3004-504 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-5718","authenticated-orcid":false,"given":"Artur","family":"Figueirinha","sequence":"additional","affiliation":[{"name":"Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), University of Porto, 4099-002 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-821X","authenticated-orcid":false,"given":"L\u00edgia","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Univ Coimbra, Chemical Engineering and Renewable Resources for Sustainability (CERES), Department of Chemical Engineering, 3030-790 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024, April 26). 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