{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:22:27Z","timestamp":1792844547829,"version":"4.5.0"},"reference-count":165,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Executive Agency","award":["HORIZON-MSCA-2022-SE-01-01"],"award-info":[{"award-number":["HORIZON-MSCA-2022-SE-01-01"]}]},{"name":"European Research Executive Agency","award":["101131420"],"award-info":[{"award-number":["101131420"]}]},{"name":"HORIZON TMA MSCA Staff Exchanges","award":["HORIZON-MSCA-2022-SE-01-01"],"award-info":[{"award-number":["HORIZON-MSCA-2022-SE-01-01"]}]},{"name":"HORIZON TMA MSCA Staff Exchanges","award":["101131420"],"award-info":[{"award-number":["101131420"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This review investigates innovative strategies for upcycling agricultural residues into valuable pharmaceutical compounds. The improper disposal of agricultural residues contributes to significant environmental issues, including increased greenhouse gas emissions and ecosystem degradation. Upcycling offers a sustainable solution, transforming these residues into high-value bioproducts (antioxidants, antitumor agents, antidiabetic compounds, anti-inflammatory agents, and antiviral drugs). Nanotechnology and microbial biotechnology have a crucial role in enhancing bioavailability and targeted delivery of bioactive compounds. Advanced techniques like enzymatic hydrolysis, green solvents, microwave processing, pyrolysis, ultrasonic processing, acid and alkaline hydrolysis, ozonolysis, and organosolv processes are explored for their effectiveness in breaking down agricultural waste and extracting valuable compounds. Despite the promising potential, challenges such as variability in residue composition, scalability, and high costs persist. The review emphasizes the need for future research on cost-effective extraction techniques and robust regulatory frameworks to ensure the safety, efficacy, and quality of bioproducts. The upcycling of agricultural residues represents a viable path towards sustainable waste management and production of pharmaceutical compounds, contributing to environmental conservation and public health improvements. This review provides an analysis of the current literature and identifies knowledge gaps, offering recommendations for future studies to optimize the use of agricultural residues in the drug industry.<\/jats:p>","DOI":"10.3390\/plants13152133","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T11:34:20Z","timestamp":1722512060000},"page":"2133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Innovative Strategies for Upcycling Agricultural Residues and Their Various Pharmaceutical Applications"],"prefix":"10.3390","volume":"13","author":[{"given":"Ludovic Everard","family":"Bejenaru","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-2736","authenticated-orcid":false,"given":"Antonia","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-8094","authenticated-orcid":false,"given":"Adina-Elena","family":"Segneanu","sequence":"additional","affiliation":[{"name":"Institute for Advanced Environmental Research, West University of Timi\u015foara (ICAM\u2013WUT), 4 Oituz Street, 300086 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-1423","authenticated-orcid":false,"given":"Andrei","family":"Bi\u0163\u0103","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-1497","authenticated-orcid":false,"given":"Costel-Valentin","family":"Manda","sequence":"additional","affiliation":[{"name":"Department of Analytical and Instrumental Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-9277","authenticated-orcid":false,"given":"George Dan","family":"Mogo\u015fanu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Bejenaru","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bala, S., Garg, D., Sridhar, K., Inbaraj, B.S., Singh, R., Kamma, S., Tripathi, M., and Sharma, M. 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