{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:56:32Z","timestamp":1793051792597,"version":"4.5.0"},"reference-count":53,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Fund 2024, Chiang Mai University","award":["N42A671052"],"award-info":[{"award-number":["N42A671052"]}]},{"name":"Fundamental Fund 2024, Chiang Mai University","award":["CoE\/RG66\/67-P001"],"award-info":[{"award-number":["CoE\/RG66\/67-P001"]}]},{"name":"Thailand Research Fund (TRF) Research Team Promotion Grant, RTA, Senior Research Scholar","award":["N42A671052"],"award-info":[{"award-number":["N42A671052"]}]},{"name":"Thailand Research Fund (TRF) Research Team Promotion Grant, RTA, Senior Research Scholar","award":["CoE\/RG66\/67-P001"],"award-info":[{"award-number":["CoE\/RG66\/67-P001"]}]},{"name":"Center of Excellence in Agro-Bio-Circular-Green Industry (Agro-BCG), Faculty of Agro-Industry, Chiang Mai University","award":["N42A671052"],"award-info":[{"award-number":["N42A671052"]}]},{"name":"Center of Excellence in Agro-Bio-Circular-Green Industry (Agro-BCG), Faculty of Agro-Industry, Chiang Mai University","award":["CoE\/RG66\/67-P001"],"award-info":[{"award-number":["CoE\/RG66\/67-P001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The bioactive compounds in herbal extracts may provide effective hair loss treatments with fewer side effects compared to synthetic medicines. This study evaluated the effects of Buebang 3 CMU and Sanpatong rice bran extracts, macerated with dichloromethane or 95% ethanol, on hair growth promotion and hair loss prevention. Overall, Buebang 3 CMU extracts contained significantly higher levels of bioactive compounds, including \u03b3-oryzanol, tocopherols, and various polyphenols such as phytic acid, ferulic acid, and chlorogenic acid, compared to Sanpatong extracts. Additionally, ethanolic extracts demonstrated greater bioactive content and antioxidant activities than those extracted with dichloromethane. These compounds enhanced the proliferation of human hair follicle dermal papilla cells (HFDPCs) by 124.28 \u00b1 1.08% (p &lt; 0.05) and modulated anti-inflammatory pathways by reducing nitrite production to 3.20 \u00b1 0.36 \u00b5M (p &lt; 0.05). Key hair growth signaling pathways, including Wnt\/\u03b2-catenin (CTNNB1), Sonic Hedgehog (SHH, SMO, GLI1), and vascular endothelial growth factor (VEGF), were activated by approximately 1.5-fold to 2.5-fold compared to minoxidil. Also, in both human prostate cancer (DU-145) and HFDPC cells, the ethanolic Buebang 3 CMU extract (Et-BB3-CMU) suppressed SRD5A1, SRD5A2, and SRD5A3 expression\u2014key pathways in hair loss\u2014by 2-fold and 1.5-fold more than minoxidil and finasteride, respectively. These findings suggest that Et-BB3-CMU holds promise for promoting hair growth and preventing hair loss.<\/jats:p>","DOI":"10.3390\/plants13213079","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T09:49:14Z","timestamp":1730454554000},"page":"3079","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza sativa L. cv. Buebang 3 CMU and Sanpatong"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-169X","authenticated-orcid":false,"given":"Anurak","family":"Muangsanguan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3940-6441","authenticated-orcid":false,"given":"Warintorn","family":"Ruksiriwanich","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-2890","authenticated-orcid":false,"given":"Chaiwat","family":"Arjin","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sansanee","family":"Jamjod","sequence":"additional","affiliation":[{"name":"Department of Plant and Soil Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Lanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-5150","authenticated-orcid":false,"given":"Chanakan","family":"Prom-u-Thai","sequence":"additional","affiliation":[{"name":"Department of Plant and Soil Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Lanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pensak","family":"Jantrawut","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-4433","authenticated-orcid":false,"given":"Pornchai","family":"Rachtanapun","sequence":"additional","affiliation":[{"name":"Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patipan","family":"Hnorkaew","sequence":"additional","affiliation":[{"name":"Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-4047","authenticated-orcid":false,"given":"Apinya","family":"Satsook","sequence":"additional","affiliation":[{"name":"Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathukorn","family":"Sainakham","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-3640","authenticated-orcid":false,"given":"Juan Manuel","family":"Castagnini","sequence":"additional","affiliation":[{"name":"Research Group in Innovative Technologies for Sustainable Food (ALISOST), Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de Val\u00e8ncia, Avenida Vicent Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-8183","authenticated-orcid":false,"given":"Korawan","family":"Sringarm","sequence":"additional","affiliation":[{"name":"Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clindermatol.2021.08.013","article-title":"Lasers, lights, and compounds for hair loss in aesthetics","volume":"40","author":"Ring","year":"2022","journal-title":"Clin. 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