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Current treatment for H. pylori infection involves a multi-drug therapeutic regime with various adverse effects, which leads to treatment abandonment and contributes to the emergence of resistant strains of H. pylori. Previously, we demonstrated that the essential oil of Campomanesia lineatifolia leaves exhibited an anti-H. pylori activity. In this study, we aimed to evaluate the phenolic content of the phenolic-rich ethanol extract (PEE) from C. lineatifolia and its anti-H. pylori and antioxidant properties. Additionally, the anti-H. pylori activity was assessed in polar and non-polar fractions from PEE, isolated myricitrin (MYR) and a mixture of myricitrin and quercitrin (MYR\/QUER) from polar fractions, and aqueous extract (tea) to correlate the responsible fractions or compounds with the observed activity. Broth microdilution assays were performed to assess the anti-H. pylori activity using type cultures (ATCC 49503, NCTC 11638, both clarithromycin-sensitive) and clinical isolate strains (SSR359, clarithromycin-sensitive, and SSR366, clarithromycin-resistant). The antioxidant activity was evaluated using the DPPH assay. The total tannin and flavonoid contents were determined using the hide-powder method, the Folin-Ciocalteu reagent, and the aluminium chloride colourimetric assay, respectively. The tea (MIC 1:100), PEE, polar and non-polar fractions, MYR, and MYR\/QUER inhibited the growth of H. pylori strains tested (MIC values ranging from 0.49 to 250 \u03bcg\/mL). The antioxidant assays revealed that PEE exhibited a higher antioxidant activity (EC50 = 18.47 \u03bcg\/mL), which correlated to the high phenolic content (tannin and flavonoid, 22.31 and 0.15% w\/w, respectively). These findings support the traditional use of C. lineatifolia as a multitarget medicinal plant for treating gastric ulcers and reinforce the potential use of the species as a coadjuvant in therapeutic regimes involving patients with resistant H. pylori infection.<\/jats:p>","DOI":"10.3390\/plants13223117","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:30:48Z","timestamp":1730788248000},"page":"3117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioactive Properties of Campomanesia lineatifolia: Correlation Between Anti-Helicobacter pylori Activity, Antioxidant Potential and Chemical Composition"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-7925","authenticated-orcid":false,"given":"N\u00edvea Cristina Vieira","family":"Neves","sequence":"first","affiliation":[{"name":"GnosiaH, Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"},{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Institute, Trinity College Dublin, Dublin 2, D02 PN40 Dublin, Ireland"},{"name":"Departamento de Farm\u00e1cia, Centro Universit\u00e1rio Santa Rita, Conselheiro Lafaiete 36408-899, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgana Pinheiro","family":"de Mello","sequence":"additional","affiliation":[{"name":"GnosiaH, Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-3590","authenticated-orcid":false,"given":"Sin\u00e9ad Marian","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Trinity Centre, Tallaght University Hospital, Dublin 24, D24 NR0A Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-1787","authenticated-orcid":false,"given":"Fabio","family":"Boylan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Institute, Trinity College Dublin, Dublin 2, D02 PN40 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-8407","authenticated-orcid":false,"given":"Marcelo Vidigal","family":"Caliari","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel Oliveira","family":"Castilho","sequence":"additional","affiliation":[{"name":"GnosiaH, Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"},{"name":"Cons\u00f3rcio Acad\u00eamico Brasileiro de Sa\u00fade Integrativa, CABSIN, S\u00e3o Paulo 05449-070, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sun, Q., Yuan, C., Zhou, S., Lu, J., Zeng, M., Cai, X., and Song, H. 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