{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:31:57Z","timestamp":1791919917986,"version":"4.3.4"},"reference-count":179,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Common Juniper (Juniperus communis L.) is a gymnosperm that stands out through its fleshy, spherical female cones, often termed simply \u201cberries\u201d. The cone berries and various vegetative parts (leaves, twigs and even roots) are used in traditional phytotherapy, based on the beneficial effects exerted by a variety of secondary metabolites. While the volatile compounds of Juniperus communis are known for their aromatic properties and have been well-researched for their antimicrobial effects, this review shifts focus to non-volatile secondary metabolites\u2014specifically diterpenes, lignans, and biflavonoids. These compounds are of significant biomedical interest due to their notable pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. The aim of this review is to offer an up-to-date account of chemical composition of Juniperus communis and related species, with a primary emphasis on the bioactivities of diterpenes, lignans, and biflavonoids. By examining recent preclinical and clinical data, this work assesses the therapeutic potential of these metabolites and their mechanisms of action, underscoring their value in developing new therapeutic options. Additionally, this review addresses the pharmacological efficacy and possible therapeutic applications of Juniperus communis in treating various human diseases, thus supporting its potential role in evidence-based phytotherapy.<\/jats:p>","DOI":"10.3390\/plants13223233","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:03:14Z","timestamp":1731934994000},"page":"3233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Beyond Essential Oils: Diterpenes, Lignans, and Biflavonoids from Juniperus communis L. as a Source of Multi-Target Lead Compounds"],"prefix":"10.3390","volume":"13","author":[{"given":"Alina Arabela","family":"Joji\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Research Center for Pharmacotoxicologic Evaluations (FARMTOX), \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4866-934X","authenticated-orcid":false,"given":"Sergio","family":"Liga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Department of Applied Chemistry and Engineering of Organic and Natural Compounds, Faculty of Chemical Engineering, Biotechnologies and Environmental Protection, Politehnica University Timisoara, 6 Vasile Parvan, 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7708-7314","authenticated-orcid":false,"given":"Diana","family":"U\u0163u","sequence":"additional","affiliation":[{"name":"Department of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u0163iana","family":"Ruse","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Suciu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-7677","authenticated-orcid":false,"given":"Andrei","family":"Motoc","sequence":"additional","affiliation":[{"name":"Department of Anatomy-Embryology, Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codru\u021ba Marinela","family":"\u015eoica","sequence":"additional","affiliation":[{"name":"Department of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Research Center for Pharmacotoxicologic Evaluations (FARMTOX), \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-8595","authenticated-orcid":false,"given":"Diana-Simona","family":"Tchiakpe-Antal","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacotoxicologic Evaluations (FARMTOX), \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-7847.95849","article-title":"Historical Review of Medicinal Plants\u2019 Usage","volume":"6","author":"Petrovska","year":"2012","journal-title":"Pharmacogn. 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