{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:52:12Z","timestamp":1789609932927,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","award":["451-03-66\/2024-03\/200003"],"award-info":[{"award-number":["451-03-66\/2024-03\/200003"]}]},{"name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","award":["451-03-66\/2024-03\/200113"],"award-info":[{"award-number":["451-03-66\/2024-03\/200113"]}]},{"name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","award":["451-03-65\/2024-03\/200113"],"award-info":[{"award-number":["451-03-65\/2024-03\/200113"]}]},{"name":"Faculty of Medicine, University of Nis","award":["451-03-66\/2024-03\/200003"],"award-info":[{"award-number":["451-03-66\/2024-03\/200003"]}]},{"name":"Faculty of Medicine, University of Nis","award":["451-03-66\/2024-03\/200113"],"award-info":[{"award-number":["451-03-66\/2024-03\/200113"]}]},{"name":"Faculty of Medicine, University of Nis","award":["451-03-65\/2024-03\/200113"],"award-info":[{"award-number":["451-03-65\/2024-03\/200113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Red currant (Ribes rubrum L.) berries are rich in bioactive compounds and exhibit nutritive and protective features. This research examined the content of secondary metabolites of the red currant variety Redpoll lyophilized juice and waste extract and their antioxidative and spasmolytic effects. The flavonol and anthocyanin contents of the samples were determined using high-performance liquid chromatography. The antispasmodic effects were assessed in in vitro conditions, and the potential impact of the samples and possible action mechanisms were revealed. The results showed the prevalence of cyanidin-3-O-glucoside as the dominant anthocyanin with higher content in the juice sample. Quercetin content, as the prevalent flavonol, was higher in the waste sample. The berry juice showed a greater ability for scavenging free radicals, whereas the waste better inhibited lipid peroxidation. The juice was a superior antispasmodic agent for spontaneous, KCl-, CaCl2-, BaCl2-, histamine-, and acetylcholine-induced ileal contractions. This first evaluation of the red currant variety Redpoll lyophilized juice and waste extract indicated the beneficial effects of juice as an antioxidant and spasmolytic agent. Therefore, this red currant juice sample could be designated for the prevention or treatment of gastrointestinal disorders.<\/jats:p>","DOI":"10.3390\/plants14020234","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T04:55:19Z","timestamp":1737003319000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Red Currant (Ribes rubrum L.) Fruit Waste Extract and Juice as Potential Spasmolytic Agents"],"prefix":"10.3390","volume":"14","author":[{"given":"Maja","family":"Cvetkovi\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-6519","authenticated-orcid":false,"given":"Bojana","family":"Miladinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1814-9844","authenticated-orcid":false,"given":"Suzana","family":"Brankovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-9957","authenticated-orcid":false,"given":"Milica","family":"Randjelovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-8471","authenticated-orcid":false,"given":"Slavoljub","family":"\u017divanovi\u0107","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1440-9257","authenticated-orcid":false,"given":"Nemanja","family":"Kiti\u0107","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-3840","authenticated-orcid":false,"given":"Milica","family":"Milutinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-0929","authenticated-orcid":false,"given":"Milo\u0161","family":"Jovanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-3311","authenticated-orcid":false,"given":"Du\u0161ica","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Hygiene with Medical Ecology, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0966-3962","authenticated-orcid":false,"given":"Haris","family":"Nik\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-9593","authenticated-orcid":false,"given":"Katarina","family":"\u0160avikin","sequence":"additional","affiliation":[{"name":"Institute for Medicinal Plants Research \u201cDr Josif Pan\u010di\u0107\u201d, Tadeu\u0161a Ko\u0161\u0107u\u0161ka 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-274X","authenticated-orcid":false,"given":"Du\u0161anka","family":"Kiti\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Dr. Zoran Djindji\u0107 Ave 81, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/j.gastro.2023.05.050","article-title":"Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019","volume":"165","author":"Wang","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_2","unstructured":"(2024, June 05). 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