{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:38:54Z","timestamp":1790185134904,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32371929"],"award-info":[{"award-number":["32371929"]}]},{"name":"National Natural Science Foundation of China","award":["2024MD753913"],"award-info":[{"award-number":["2024MD753913"]}]},{"name":"China Postdoctoral Science Foundation","award":["32371929"],"award-info":[{"award-number":["32371929"]}]},{"name":"China Postdoctoral Science Foundation","award":["2024MD753913"],"award-info":[{"award-number":["2024MD753913"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Broussonetia papyrifera (L.) L\u2019H\u00e9r. ex Vent., a dioecious tree species that belongs to the Moraceae family, is a perennial plant found extensively throughout China. Its leaves are rich in essential trace elements such as copper, molybdenum, manganese, and iron, as well as various biologically active compounds, including amino acids, polysaccharides, proteins, as well as flavonoids, phenylpropanoids, and other polyphenolic compounds. These compounds exhibit significant pharmacological effects, such as antioxidant, lipid-lowering, heat-clearing, detoxifying, blood-cooling, diuretic, and immunomodulatory activities. In recent years, B. papyrifera has gained attention for its medicinal potential; however, breeding efforts, especially those aimed at increasing the flavonoid content, have lagged. This study reviews the progress in research on the active medicinal ingredients of B. papyrifera, with a focus on identification methods, classification criteria, and enrichment technologies for its medicinal components. The biosynthesis of structural genes and transcription factors in flavonoids has been investigated in B. papyrifera. The pharmacological effects of the secondary metabolites of B. papyrifera were systematically examined, aiming to offer strategies for enhancing the flavonoid content and promoting its medicinal value.<\/jats:p>","DOI":"10.3390\/plants14040523","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T11:54:06Z","timestamp":1739274846000},"page":"523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Medicinal Potential of Broussonetia papyrifera: Chemical Composition and Biological Activity Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China"},{"name":"Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Hubei Engineering Research Center for Specialty Flowers Biological Breeding, Jingchu University of Technology, Jingmen 448000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China"},{"name":"Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangwen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China"},{"name":"Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China"},{"name":"Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-8880","authenticated-orcid":false,"given":"Jiabao","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China"},{"name":"Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-6284","authenticated-orcid":false,"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China"},{"name":"Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/0028825X.2010.520323","article-title":"Paper Mulberry (Broussonetia Papyrifera) as a Commensal Model for Human Mobility in Oceania: Anthropological, Botanical and Genetic Considerations","volume":"48","author":"Seelenfreund","year":"2010","journal-title":"N. 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