{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T16:45:34Z","timestamp":1776617134983,"version":"3.51.2"},"reference-count":86,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Argentina","award":["CONICET-PIP 2021-2023"],"award-info":[{"award-number":["CONICET-PIP 2021-2023"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Argentina","award":["11220200103136CO"],"award-info":[{"award-number":["11220200103136CO"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Argentina","award":["PICT- D-2018-02446"],"award-info":[{"award-number":["PICT- D-2018-02446"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["CONICET-PIP 2021-2023"],"award-info":[{"award-number":["CONICET-PIP 2021-2023"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["11220200103136CO"],"award-info":[{"award-number":["11220200103136CO"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["PICT- D-2018-02446"],"award-info":[{"award-number":["PICT- D-2018-02446"]}]},{"name":"Universidad Nacional de C\u00f3rdoba","award":["CONICET-PIP 2021-2023"],"award-info":[{"award-number":["CONICET-PIP 2021-2023"]}]},{"name":"Universidad Nacional de C\u00f3rdoba","award":["11220200103136CO"],"award-info":[{"award-number":["11220200103136CO"]}]},{"name":"Universidad Nacional de C\u00f3rdoba","award":["PICT- D-2018-02446"],"award-info":[{"award-number":["PICT- D-2018-02446"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Monoterpenes (MTs) are plants\u2019 secondary metabolites and major components of essential oils (EOs), widely used in the pharmaceutical industry. However, its neuroprotective effects, particularly in Parkinson\u2019s disease (PD) have not been fully demonstrated. PD is a progressive neurological disorder marked by dopaminergic neuron loss in the substantia nigra, motor symptoms being the most reported ones. This review evaluates the evidence supporting the use of MTs as potential neuroprotective agents. PubMed, SCOPUS, Google Scholar, and ScienceDirect databases were searched for articles on MTs in murine models with any type of administration. The PRISMA guidelines were followed. After screening 405 records, 32 were included in the systematic review and 30 were included in the meta-analysis. Fifteen MTs, commonly found in EOs, were identified as potential therapeutic agents for PD. The meta-analysis revealed that MTs administration improved motor performance, increased tyrosine hydroxylase levels, reduced oxidative stress markers (malondialdehyde) and proinflammatory cytokines (IL-6, IL-1, TNF-\u03b1), and enhanced antioxidant enzymes (catalase, superoxide dismutase) in parkinsonian animals. The antioxidant and anti-inflammatory properties of MTs appear to be key mechanisms in mitigating dopaminergic neurodegeneration. However, further clinical research is essential to translate these findings into practical applications.<\/jats:p>","DOI":"10.3390\/plants14070999","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:54:48Z","timestamp":1743159288000},"page":"999","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plant-Derived Monoterpene Therapies in Parkinson\u2019s Disease Models: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Mat\u00edas","family":"J\u00e1vega-Cometto","sequence":"first","affiliation":[{"name":"Instituto de Farmacolog\u00eda Experimental de C\u00f3rdoba (IFEC-CONICET), Departamento de Farmacolog\u00eda Otto Orsingher, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8793-1830","authenticated-orcid":false,"given":"Aracely J.","family":"Naranjo-Viteri","sequence":"additional","affiliation":[{"name":"Instituto de Farmacolog\u00eda Experimental de C\u00f3rdoba (IFEC-CONICET), Departamento de Farmacolog\u00eda Otto Orsingher, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-4725","authenticated-orcid":false,"given":"Leandro G.","family":"Champarini","sequence":"additional","affiliation":[{"name":"Instituto de Farmacolog\u00eda Experimental de C\u00f3rdoba (IFEC-CONICET), Departamento de Farmacolog\u00eda Otto Orsingher, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-7024","authenticated-orcid":false,"given":"Claudia B.","family":"Here\u00f1\u00fa","sequence":"additional","affiliation":[{"name":"Instituto de Farmacolog\u00eda Experimental de C\u00f3rdoba (IFEC-CONICET), Departamento de Farmacolog\u00eda Otto Orsingher, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana","family":"Crespo","sequence":"additional","affiliation":[{"name":"Instituto de Farmacolog\u00eda Experimental de C\u00f3rdoba (IFEC-CONICET), Departamento de Farmacolog\u00eda Otto Orsingher, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Breitmaier, E. 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