{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:49:19Z","timestamp":1792507759609,"version":"4.5.0"},"reference-count":59,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"project PDI-PFE-CDI 2021","award":["40PFE\/30.12.2021"],"award-info":[{"award-number":["40PFE\/30.12.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This study investigates the phytochemical composition, anti-inflammatory, antioxidant, and antiproliferative activities of A. absinthium and A. annua flowers and leaf ethanol extracts in acute rat inflammation model. Polyphenolic compounds were analyzed quantitatively (total phenolic (TPC) and total flavonoids (TFCs)) and qualitatively by HPLC-ESI MS analysis. The antioxidant activity was evaluated in vitro (by DPPH, FRAP, H2O2, and NO scavenging tests), and in vivo (by total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and key oxidative damage markers). Inflammation was evaluated via nuclear factor-kB-p65 (NfkB-p65), and canonical NLRP3 inflammasome activation (with IL-1\u03b2, IL-18, caspase-1, and gasdermin D). The antiproliferative activity against human ovarian tumor cells (A2780cis, OVCAR-3, and OAW-42) was evaluated by the MTT assay, focusing on the modulation of multidrug resistance (MDR) pumps and the PARP-1 enzyme. Liver and renal toxicity were tested by measuring transaminases (ALT and AST), creatinine, and urea. The study results indicated that A. absinthium and A. annua flowers and leaf ethanol extracts have rich polyphenol content and moderate in vitro antioxidant activity. Tested extracts display an important antiproliferative activity against the ovarian tumor cell lines A2780cis, OVCAR-3, and OAW-42 based on chemoresistance countering and apoptotic mechanisms. There were differences related to the cell type and plant extract type. The tested plant extracts had significant and dose-dependent in vivo anti-inflammatory and antioxidant activity, with the A. annua flowers extract having the lowest efficiency. The anti-inflammatory and antioxidant activity biomarkers correlated with the extracts\u2019 chemical composition. There was no inflammation-induced hepatotoxicity, but renal dysfunction was associated. Only AANL improved the renal function. These results can be used to design and develop remedies with combined anti-inflammatory, antioxidant, and anti-proliferative activities.<\/jats:p>","DOI":"10.3390\/plants14071029","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T13:39:53Z","timestamp":1742996393000},"page":"1029","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Flowers and Leaves of Artemisia absinthium and Artemisia annua Phytochemical Characterization, Anti-Inflammatory, Antioxidant, and Anti-Proliferative Activities Evaluation"],"prefix":"10.3390","volume":"14","author":[{"given":"M\u0103d\u0103lina","family":"\u021aicolea","sequence":"first","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Pathophysiology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5977","authenticated-orcid":false,"given":"Raluca Maria","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-9280","authenticated-orcid":false,"given":"Marcel","family":"P\u00e2rvu","sequence":"additional","affiliation":[{"name":"Department of Biology, Babes-Bolyai University, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia-Oxana","family":"Usatiuc","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Pathophysiology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Uif\u0103lean","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Pathophysiology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalina Diana","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Anatomy, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-0547","authenticated-orcid":false,"given":"Eva","family":"Fischer-Fodor","sequence":"additional","affiliation":[{"name":"Tumor Biology Department, The Oncology Institute I. Chiricu\u021b\u0103, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-7932","authenticated-orcid":false,"given":"Floricu\u021ba","family":"Ranga","sequence":"additional","affiliation":[{"name":"Food Science and Technology, Department of Food Science, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crina Claudia","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"\u201cMihai Manasia\u201d Nephrology and Dialysis Clinic, County Emergency Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Florinela","family":"C\u0103toi","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Pathophysiology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Palma-Garcia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Panama, Panama City 64460, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-1011","authenticated-orcid":false,"given":"Luciana-M\u0103d\u0103lina","family":"Gherman","sequence":"additional","affiliation":[{"name":"Experimental Center, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-6844","authenticated-orcid":false,"given":"Alina Elena","family":"P\u00e2rvu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences, Discipline of Pathophysiology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI133661","article-title":"Local Microvascular Leakage Promotes Trafficking of Activated Neutrophils to Remote Organs","volume":"130","author":"Joulia","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.stem.2020.04.015","article-title":"Inflammation\u2019s Epigenetic Footprint in Hematopoietic Stem Cells","volume":"26","author":"Geiger","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, Y., Xiang, C., Que, Z., Li, C., Wang, W., Yin, L., Chu, C., and Zhou, Y. (2023). Neutrophil Heterogeneity and Aging: Implications for COVID-19 and Wound Healing. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1201651"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Beyrau, M., Bodkin, J.V., and Nourshargh, S. (2012). Neutrophil Heterogeneity in Health and Disease: A Revitalized Avenue in Inflammation and Immunity. Open Biol., 2.","DOI":"10.1098\/rsob.120134"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.immuni.2015.05.010","article-title":"Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo","volume":"42","author":"Colom","year":"2015","journal-title":"Immunity"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9870138","DOI":"10.1155\/2023\/9870138","article-title":"Oxidative Stress in End-Stage Renal Disease: Pathophysiology and Potential Interventions","volume":"2023","author":"Roumeliotis","year":"2023","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnut.2023.1157572","article-title":"Targeting Inflammasome Pathway by Polyphenols as a Strategy for Pancreatitis, Gastrointestinal and Liver Diseases Management: An Updated Review","volume":"10","author":"Nani","year":"2023","journal-title":"Front. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"108053","DOI":"10.1016\/j.pharmthera.2021.108053","article-title":"Targeting the NLRP3 Inflammasome in Cardiovascular Diseases","volume":"236","author":"Toldo","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bertinaria, M. (2021). Infammasome Inhibitors. Molecules, 26.","DOI":"10.3390\/molecules26226912"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Davidson, C.B., El Sabbagh, D.E.S., Machado, A.K., Pappis, L., Sagrillo, M.R., Somacal, S., Emanuelli, T., Schultz, J.V., Augusto Pereira da Rocha, J., and Santos, A.F.d. (2024). Euterpe Oleracea Mart. Bioactive Molecules: Promising Agents to Modulate the NLRP3 Inflammasome. Biology, 13.","DOI":"10.3390\/biology13090729"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of Antioxidants and Natural Products in Inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hasan, A., Biswas, P., Bondhon, T.A., Jannat, K., Paul, T.K., Paul, A.K., Jahan, R., Nissapatorn, V., Mahboob, T., and Wilairatana, P. (2022). Can Artemisia Herba-Alba Be Useful for Managing COVID-19 and Comorbidities?. Molecules, 27.","DOI":"10.3390\/molecules27020492"},{"key":"ref_14","first-page":"5628601","article-title":"Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles","volume":"2022","author":"Semwal","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/14786419.2016.1174234","article-title":"Chemical Composition, Antioxidant, Antibacterial and Cytotoxic Effects of Artemisia marschalliana Sprengel Extract","volume":"31","author":"Salehi","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Nurlybekova, A., Kudaibergen, A., Kazymbetova, A., Amangeldi, M., Baiseitova, A., Ospanov, M., Aisa, H.A., Ye, Y., Ibrahim, M.A., and Jenis, J. (2022). Traditional Use, Phytochemical Profiles and Pharmacological Properties of Artemisia Genus from Central Asia. Molecules, 27.","DOI":"10.3390\/molecules27165128"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104721","DOI":"10.1016\/j.fitote.2020.104721","article-title":"Anatomical Study and Histochemical Analysis of Artemisia leucodes Schrenk","volume":"146","author":"Adekenov","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jaradat, N., Dwikat, M., Amer, J., Ghanim, M., Hawash, M., Hussein, F., Issa, L., Ishtawe, S., Salah, S., and Nasser, S. (2024). Total Phenolic Contents, Cytotoxic, Free Radicals, Porcine Pancreatic \u03b1-Amylase, and Lipase Suppressant Activities of Artemisia Dracunculus Plant from Palestine. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1351743"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ekiert, H., Klimek-Szczykutowicz, M., Rzepiela, A., Klin, P., and Szopa, A. (2022). Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. Molecules, 27.","DOI":"10.3390\/molecules27196427"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"13306","DOI":"10.15835\/nbha51313306","article-title":"Chemical Composition and Anti-Inflammatory Effect of Phellodendron Amurense Rupr. Stem Bark Extract","volume":"51","author":"Erhan","year":"2023","journal-title":"Not. Bot. Horti Agrobot. Cluj-Napoca"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kiki, G.A.\u00e0., Pop, R.M., Sabin, O., Bocsan, I.C., Chedea, V.S., Socaci, S.A., P\u00e2rvu, A.E., Finsia, E., Francis, T., and Mathieu, Z. (2022). Polyphenols from Dichrostachys Cinerea Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund\u2019s Adjuvant-Induced Arthritic Rat Model. Molecules, 27.","DOI":"10.3390\/molecules27175445"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chera, E.I., Pop, R.M., P\u00e2rvu, M., Sori\u021b\u0103u, O., Uif\u0103lean, A., C\u0103toi, F.A., Cecan, A., Negoescu, A.G., Achima\u0219-Cadariu, P., and P\u00e2rvu, A.E. (2022). Flaxseed Ethanol Extracts\u2019 Antitumor, Antioxidant, and Anti-Inflammatory Potential. Antioxidants, 11.","DOI":"10.3390\/antiox11050892"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4314\/ajtcam.v8i1.60483","article-title":"Extraction, Isolation and Characterization of Bioactive Compounds from Plants Extracts","volume":"8","author":"Sasidharan","year":"2010","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.jinorgbio.2009.09.027","article-title":"Antiproliferative Effect and Genotoxicity of Novel Synthesized Palladium Complexes with Organoarsenic Ligands","volume":"103","author":"Schrepler","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.npep.2017.01.003","article-title":"Ketamine-Xylazine Anaesthesia and Orofacial Administration of Substance P: A Lethal Combination in Rats","volume":"62","author":"Francischi","year":"2017","journal-title":"Neuropeptides"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A New Automated Colorimetric Method for Measuring Total Oxidant Status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clinbiochem.2003.10.014","article-title":"A Novel Automated Method to Measure Total Antioxidant Response against Potent Free Radical Reactions","volume":"37","author":"Erel","year":"2004","journal-title":"Clin. Biochem."},{"key":"ref_28","first-page":"563","article-title":"Increased Oxidative Stress in Patients with Hydatidiform Mole","volume":"133","author":"Harma","year":"2003","journal-title":"Swiss Med. Wkly."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.31557\/APJCP.2020.21.8.2325","article-title":"Estimation of Salivary 8-Hydroxydeoxyguanosine (8-OHdG) as a Potential Biomarker in Assessing Progression towards Malignancy: A Case-Control Studyoxidative","volume":"21","author":"Nandakumar","year":"2020","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ki.1996.186","article-title":"Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Uremia","volume":"49","author":"Friedlander","year":"1996","journal-title":"Kidney Int."},{"key":"ref_31","first-page":"306","article-title":"Evaluation of Thiol Compounds and Lipid Peroxidative Products in Plasma of Patients with Copd","volume":"8","author":"Mitev","year":"2010","journal-title":"Trakia J. Sci."},{"key":"ref_32","first-page":"29","article-title":"Protein Precipitation Methods Evaluated for Determination of Serum Nitric Oxide End Products by the Griess Assay","volume":"15","author":"Ghasemi","year":"2007","journal-title":"J. Med. Sci. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A Rapid, Simple Spectrophotometric Method for Simultaneous Detection of Nitrate and Nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.humimm.2013.06.009","article-title":"3-Nitrotyrosine: A Biomarker of Nitrogen Free Radical Species Modified Proteins in Systemic Autoimmunogenic Conditions","volume":"74","author":"Ahsan","year":"2013","journal-title":"Hum. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","article-title":"A Novel and Automated Assay for Thiol\/Disulphide Homeostasis","volume":"47","author":"Erel","year":"2014","journal-title":"Clin. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"\u021aicolea, M., Pop, R.M., P\u00e2rvu, M., Usatiuc, L.-O., Uif\u0103lean, A., Ranga, F., and P\u00e2rvu, A.E. (2024). Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum. Antioxidants, 13.","DOI":"10.3390\/antiox13081016"},{"key":"ref_37","first-page":"3720850","article-title":"Crude Aloe Vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement in Vitro","volume":"2016","author":"Taukoorah","year":"2016","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Saunoriute, S.S., Raga\u017einskiene, O., Ivanauskas, L., Marksa, M., Lau\u017eike, K., and Lina, R. (2023). Separations Phenolic Diversity and Antioxidant Activity of Artemisia abrotanum L. and Artemisia absinthium L. during Vegetation Stages. Separations, 10.","DOI":"10.3390\/separations10100545"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Abotaleb, M., Liskova, A., Kubatka, P., and B\u00fcsselberg, D. (2020). Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer. Biomolecules, 10.","DOI":"10.3390\/biom10020221"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bhatti, M.Z., Ali, A., Ahmad, A., Saeed, A., and Malik, S.A. (2015). Antioxidant and Phytochemical Analysis of Ranunculus Arvensis L. Extracts. BMC Res. Notes, 8.","DOI":"10.1186\/s13104-015-1228-3"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.sjbs.2012.04.004","article-title":"Antioxidant Activity of Polyphenolic Extracts of Ichnocarpus Frutescens","volume":"19","author":"Kumarappan","year":"2012","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Benzie, I.F.F., and Devaki, M. (2017). The Ferric Reducing\/Antioxidant Power (FRAP) Assay for Non-Enzymatic Antioxidant Capacity: Concepts, Procedures, Limitations and Applications. Measurement of Antioxidant Activity & Capacity, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781119135388.ch5"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.5530\/ax.2011.2.8","article-title":"In Vitro Antioxidant Studies of Sitopaladi Churna, a Polyherbal Ayurvedic Formulation","volume":"1","author":"Makhija","year":"2011","journal-title":"Free Radic. Antioxid."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Albensi, B.C. (2019). What Is Nuclear Factor Kappa B (NF-\u039aB) Doing in and to the Mitochondrion?. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00154"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e20190314","DOI":"10.1084\/jem.20190314","article-title":"Inflammasome Signaling and Regulation of Interleukin-1 Family Cytokines","volume":"217","author":"Chan","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u039aB Pathway for the Therapy of Diseases: Mechanism and Clinical Study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"220028","DOI":"10.1183\/16000617.0028-2022","article-title":"Polyphenols, Flavonoids and Inflammasomes: The Role of Cigarette Smoke in COPD","volume":"31","author":"Fu","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"O\u2019Keefe, M.E., Dubyak, G.R., and Abbott, D.W. (2024). Post-Translational Control of NLRP3 inflammasome Signaling. J. Biol. Chem., 300.","DOI":"10.1016\/j.jbc.2024.107386"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kopustinskiene, D.M., Jakstas, V., Savickas, A., and Bernatoniene, J. (2020). Flavonoids as Anticancer Agents. Nutrients, 12.","DOI":"10.3390\/nu12020457"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/nm.2514","article-title":"The Neutrophil in Vascular Inflammation","volume":"17","author":"Phillipson","year":"2011","journal-title":"Nat. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Elgendy, S.A., Baloza, S.H., Mohammed, L.A., Nasr, H.E., Osama El-Shaer, N., Ghamry, H.I., Althobaiti, S.A., Shukry, M., Soliman, M.M., and Elnoury, H.A. (2022). Ameliorative Impacts of Wheat Germ Oil against Ethanol-Induced Hepatic and Renal Dysfunction in Rats: Involvement of Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Signaling Pathways. Life, 12.","DOI":"10.3390\/life12101671"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rasool, R., Ullah, I., Shahid, S., Mubeen, B., Imam, S.S., Alshehri, S., Ghoneim, M.M., Alzarea, S.I., Murtaza, B.N., and Nadeem, M.S. (2022). In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats. Molecules, 27.","DOI":"10.3390\/molecules27051608"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e13098","DOI":"10.1111\/eci.13098","article-title":"Advanced Oxidation Protein Products Play Critical Roles in Liver Diseases","volume":"49","author":"Zhao","year":"2019","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.redox.2013.07.006","article-title":"Biological Markers of Oxidative Stress: Applications to Cardiovascular Research and Practice","volume":"1","author":"Ho","year":"2013","journal-title":"Redox Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jim.2017.06.012","article-title":"Optimized Incubation Regime for Nitric Oxide Measurements in Murine Macrophages Using the Griess Assay","volume":"449","author":"Wallert","year":"2017","journal-title":"J. Immunol. Methods"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.7314\/APJCP.2014.15.11.4405","article-title":"Oxidative Stress and Antioxidants in Disease and Cancer: A Review","volume":"15","author":"Gupta","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"58","DOI":"10.36062\/ijah.60.1.2021.58-65","article-title":"Sex-Specific Reference Intervals for Wistar Albino Rats: Hematology and Clinical Biochemistry","volume":"60","author":"Vigneshwar","year":"2021","journal-title":"Indian J. Anim. Health"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Andrade-Oliveira, V., Foresto-Neto, O., Watanabe, I.K.M., Zatz, R., and C\u00e2mara, N.O.S. (2019). Inflammation in Renal Diseases: New and Old Players. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01192"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kadatane, S.P., Satariano, M., Massey, M., Mongan, K., and Raina, R. (2023). The Role of Inflammation in CKD. 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