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Conventional treatments typically rely on chemical-based products which, although effective, are often associated with undesirable side effects such as tooth staining, altered taste, and the development of antimicrobial resistance. As a response, plant-based natural alternatives have gained attention as promising strategies for the prevention and management of dental caries. This review highlights the antibacterial properties of medicinal plants and their potential applications in dentistry, with a particular focus on their activity against a broad range of bacteria and microorganisms involved in oral diseases. Numerous plant extracts and bioactive compounds\u2014including polyphenols, flavonoids, and essential oils\u2014have demonstrated antimicrobial, anti-inflammatory, and antioxidant properties that contribute to maintaining oral health. Although in vitro and in vivo studies support their therapeutic potential, clinical trials assessing long-term efficacy and safety remain scarce. Future research should prioritize the standardization of extraction methods, dosage, and formulations to facilitate the integration of these natural alternatives into conventional dental care practices.<\/jats:p>","DOI":"10.3390\/plants14091390","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:31:36Z","timestamp":1746419496000},"page":"1390","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Medicinal Plants Against Dental Caries: Research and Application of Their Antibacterial Properties"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-3774","authenticated-orcid":false,"given":"Marcela Alejandra","family":"Gloria-Garza","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Dr. Eduardo Aguirre Peque\u00f1o S\/N, Monterrey 64460, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-6459","authenticated-orcid":false,"given":"Gustavo Ra\u00fal","family":"Reyna-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad S\/N, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-0899","authenticated-orcid":false,"given":"Zacar\u00edas","family":"Jim\u00e9nez-Salas","sequence":"additional","affiliation":[{"name":"Facultad de Salud P\u00fablica y Nutrici\u00f3n, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Dr. Eduardo Aguirre Peque\u00f1o S\/N, Monterrey 64460, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Campos-G\u00f3ngora","sequence":"additional","affiliation":[{"name":"Facultad de Salud P\u00fablica y Nutrici\u00f3n, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Dr. Eduardo Aguirre Peque\u00f1o S\/N, Monterrey 64460, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-0222","authenticated-orcid":false,"given":"Miroslava","family":"Ka\u010d\u00e1niov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Horticulture, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, Slovakia"},{"name":"School of Medical & Health Sciences, University of Economics and Human Sciences in Warsaw, Okopowa 59, 01 043 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Elena","family":"Aguirre-Cavazos","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad S\/N, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-1488","authenticated-orcid":false,"given":"Minerva","family":"Bautista-Villarreal","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad S\/N, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Leos-Rivas","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad S\/N, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-5939","authenticated-orcid":false,"given":"Joel Horacio","family":"Elizondo-Luevano","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad S\/N, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"},{"name":"Facultad de Agronom\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Francisco I. Madero S\/N, Ex Hacienda el Canada, General Escobedo 66050, NL, Mexico"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno S\/N, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Homayouni Rad, A., Pourjafar, H., and Mirzakhani, E. (2023). A Comprehensive Review of the Application of Probiotics and Postbiotics in Oral Health. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1120995"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chen, X., Daliri, E.B.-M., Kim, N., Kim, J.-R., Yoo, D., and Oh, D.-H. (2020). Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms. 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