{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:29:30Z","timestamp":1789140570634,"version":"build-2803163510"},"reference-count":110,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Scorzonera undulata (S. undulata) is a medicinal plant that is traditionally used to treat various health conditions, including diabetes, constipation, diarrhea, and other digestive issues. However, comprehensive analysis of its traditional uses, phytochemistry, and pharmacological applications is still lacking. This review aims to systematically consolidate available information on the ethnopharmacological relevance, chemical profiles, and pharmacological activities of S. undulata. A comprehensive literature review of S. undulata was conducted across multiple scientific databases. Based on predefined inclusion criteria (full-text English publications providing relevant data on S. undulata) and exclusion criteria (abstracts only, studies on other species), 29 relevant studies were selected. This review systematically integrated traditional ethnobotanical knowledge with modern scientific insights, analyzing phytochemical compositions, biological activities, and pharmacological potential through a methodology designed to ensure unbiased selection from diverse sources. Traditional uses of S. undulata include treatments for diabetes, gastrointestinal disorders, snake bites, dehydration, and burns. Phytochemical studies revealed a wealth of polyphenols, flavonoids, tannins, glycosides, terpenoids, and sesquiterpenoids. In vitro and in vivo assays showed antibacterial, antifungal, anti-inflammatory, antidiabetic, antihypertensive, cytotoxic, and antioxidant properties. There are insufficient toxicity studies to assess the safety of this species. However, pharmacological research on this species remains limited. This review is the first to synthesize the traditional uses, phytochemistry, and biological activities of S. undulata, highlighting its pharmacological potential. However, further comprehensive research, including clinical trials, toxicological evaluations, and mechanistic studies, is necessary to fully identify active compounds and confirm their therapeutic applications, thus warranting additional investigation into this medicinal herb\u2019s complete benefits.<\/jats:p>","DOI":"10.3390\/plants14111606","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:16:22Z","timestamp":1748204182000},"page":"1606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Scorzonera undulata: Traditional Applications, Phytochemical Analysis, and Biological and Pharmacological Attributes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-9088","authenticated-orcid":false,"given":"Mohammed","family":"Ajebli","sequence":"first","affiliation":[{"name":"Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, Meknes 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-1419","authenticated-orcid":false,"given":"Ayoub","family":"Amssayef","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology, Conservation and Valorization of Bioressources (BCVB), Research Unit: Api-Phytotherapy, Physiology, Environnement and Health, Department of Biology, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez 30003, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryame","family":"Sabiri","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Chemistry and Natural Substances, Faculty of Sciences, Moulay Ismail University, Meknes 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Zahrae","family":"Radi","sequence":"additional","affiliation":[{"name":"Higher Institute of Nursing Professions and Technics of Health (ISPITS), Fez 30050, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8366-4739","authenticated-orcid":false,"given":"Eimad Dine Tariq","family":"Bouhlali","sequence":"additional","affiliation":[{"name":"Oasis Systems Research Unit, Regional Center of Agricultural Research of Errachidia, National Institute of Agricultural Research, Avenue Ennasr, BP 415 Rabat Principale, Rabat 10090, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6462-489X","authenticated-orcid":false,"given":"Mohamed","family":"Eddouks","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, Meknes 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116787","DOI":"10.1016\/j.jep.2023.116787","article-title":"The genus Scorzonera L. 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