{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:47:01Z","timestamp":1784335621592,"version":"3.55.0"},"reference-count":189,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cooperative Research Program for Agriculture Science and Technology Development","award":["RS-2025-02223124"],"award-info":[{"award-number":["RS-2025-02223124"]}]},{"name":"Cooperative Research Program for Agriculture Science and Technology Development","award":["PSAU\/2025\/R\/1446"],"award-info":[{"award-number":["PSAU\/2025\/R\/1446"]}]},{"name":"Republic of Korea and Prince Sattam Bin Abdulaziz University","award":["RS-2025-02223124"],"award-info":[{"award-number":["RS-2025-02223124"]}]},{"name":"Republic of Korea and Prince Sattam Bin Abdulaziz University","award":["PSAU\/2025\/R\/1446"],"award-info":[{"award-number":["PSAU\/2025\/R\/1446"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Gynura procumbens is a commonly adopted medicinal plant native to the tropical regions of East and Southeast Asia and is well recognized for its significant therapeutic potential. Traditionally used in herbal medicine, it has been employed to manage various conditions, including hypertension, diabetes, renal disorders, constipation, and inflammation. Its leaves are particularly rich in flavonoids\u2014such as astragalin, kaempferol, quercetin, myricetin, and rutin\u2014which are associated with anti-glycaemic, anticancer, antihypertensive, antimicrobial, and antioxidant activities. These bioactive constituents form the basis of the broad pharmacological profile of the plant. Emerging studies also suggest a potential role for G. procumbens in the management of infertility, further broadening its therapeutic scope. This review provides a concise overview of its phytochemical constituents, taxonomic classification, and current pharmacological evidence, highlighting its potential as a valuable candidate for novel drug development.<\/jats:p>","DOI":"10.3390\/plants14172714","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T14:02:46Z","timestamp":1756735366000},"page":"2714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacological Overview of Bioactive Natural Products from Gynura procumbens (Lour.) Merr"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2234-228X","authenticated-orcid":false,"given":"Ponkti Addrita","family":"Bose","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, Jagannath University, Dhaka 1100, Bangladesh"},{"name":"Biotechnology Research Initiative for Sustainable Development, Dhaka 1219, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-1626","authenticated-orcid":false,"given":"Md Mehadi Hasan","family":"Sohag","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, Jagannath University, Dhaka 1100, Bangladesh"},{"name":"Biotechnology Research Initiative for Sustainable Development, Dhaka 1219, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-5219","authenticated-orcid":false,"given":"Muhammad Fazle","family":"Rabbee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9579-745X","authenticated-orcid":false,"given":"Tareque Muzahid","family":"Zamee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jab-un-nisha","family":"Kona","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonhi","family":"Elora","sequence":"additional","affiliation":[{"name":"Anandaniketan, Sylhet 3100, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-4837","authenticated-orcid":false,"given":"Randa Mohammed","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia"},{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3282-6942","authenticated-orcid":false,"given":"Kamrul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-9187","authenticated-orcid":false,"given":"Kwang-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Seth, C., Schmid, V., Mueller, S., Haykowsky, M., Foulkes, S.J., Halle, M., and Wernhart, S. 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