{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:25:43Z","timestamp":1785129943855,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407192\/2018-2"],"award-info":[{"award-number":["407192\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0108-2.08\/14"],"award-info":[{"award-number":["APQ-0108-2.08\/14"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0628-2.10\/21"],"award-info":[{"award-number":["APQ-0628-2.10\/21"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-2144-2.08\/42"],"award-info":[{"award-number":["APQ-2144-2.08\/42"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["IBPG-1271-2.00\/22"],"award-info":[{"award-number":["IBPG-1271-2.00\/22"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Plants"],"abstract":"<jats:p>Schinus terebinthifolia Raddi. leaf lectin (SteLL) has been investigated for its neuromodulatory effects. Given the etiological diversity of depression, this study evaluated the effects of SteLL in a pharmacological model induced by reserpine. Mice were administered reserpine intraperitoneally for 10 days to induce anxiety- and depression-like symptoms. Before reserpine administration, animals also received SteLL (2 or 4 mg\/kg, i.p.) or fluoxetine (10 mg\/kg, i.p.) for 10 days. Behavioral assessments included the open field test, elevated plus maze, and tail suspension test. Body weight variation and brain levels of cytokines, noradrenaline, dopamine, and serotonin were also analyzed. In reserpine-treated mice, SteLL administration (2 and 4 mg\/kg) produced anxiolytic-like effects in the open field (reduced number of rearings) and elevated plus maze (increased time spent in open arms) and significantly reduced immobility time in the tail suspension test. Additionally, SteLL prevented the body weight loss typically induced by reserpine. SteLL treatment modulated neuroinflammation by reducing IL-2 and increasing IL-10 levels in the brain. SteLL treatment restored dopaminergic and noradrenergic levels, with no effect on serotonin. In conclusion, SteLL was effective in reserpine-induced monoaminergic depletion, reversing behavioral and biochemical alterations characteristic of depression, likely through dopaminergic, noradrenergic, and anti-inflammatory mechanisms.<\/jats:p>","DOI":"10.3390\/plants14193048","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T08:20:28Z","timestamp":1759393228000},"page":"3048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Schinus terebinthifolia Raddi. Leaf Lectin (SteLL) Demonstrates Anxiolytic and Antidepressant Effects Under Monoaminergic Deficiency Induced by Reserpine"],"prefix":"10.3390","volume":"14","author":[{"given":"B\u00e1rbara Ra\u00edssa Ferreira de","family":"Lima","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leydianne Leite de Siqueira","family":"Patriota","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda de Oliveira","family":"Marinho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4685-6711","authenticated-orcid":false,"given":"Thiago Lucas da Silva","family":"Lira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-9329","authenticated-orcid":false,"given":"Jainaldo Alves da","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Galdino","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia Qu\u00edmica, Centro de Tecnologia e Geoci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Carla","family":"Napole\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia Qu\u00edmica, Centro de Tecnologia e Geoci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Vin\u00edcius Fernandes Lima","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia Qu\u00edmica, Centro de Tecnologia e Geoci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelly Cristiny","family":"Pereira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife 50670-901, Brazil"},{"name":"Departamento de Fisiologia e Farmacologia, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-6012","authenticated-orcid":false,"given":"Moacyr Jesus Barreto de Melo","family":"Rego","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"},{"name":"N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-0338","authenticated-orcid":false,"given":"Maira Galdino da Rocha","family":"Pitta","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"},{"name":"N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-2602","authenticated-orcid":false,"given":"Thiago Henrique","family":"Napole\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-3833","authenticated-orcid":false,"given":"Michelle Melgarejo","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"},{"name":"N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Maria Guedes","family":"Paiva","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.31887\/DCNS.2015.17.3\/macrocq","article-title":"A history of anxiety: From Hippocrates to DSM","volume":"17","author":"Crocq","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_2","unstructured":"Muskin, P.R. (2025, June 22). What Are Anxiety Disorders?, Available online: https:\/\/www.psychiatry.org\/patients-families\/anxiety-disorders\/what-are-anxiety-disorders\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"27172","DOI":"10.1007\/s11356-021-18359-5","article-title":"Investigation of Cochlospermum religiosum leaves for antidepressant and anxiolytic activities and its synergistic effect with imipramine and fluoxetine","volume":"29","author":"Bhatt","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_4","unstructured":"World Health Organization (WHO) (2025, June 22). COVID-19 Pandemic Triggers 25% Increase in Prevalence of Anxiety and Depression Worldwide. WHO 2022. Available online: https:\/\/www.who.int\/news\/item\/02-03-2022-covid-19-pandemic-triggers-25-increase-in-prevalence-of-anxiety-and-depression-worldwide."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kim, Y.R., Park, B.K., Seo, C.S., Kim, N.S., and Lee, M.Y. (2021). Antidepressant and anxiolytic-like effects of the stem bark extract of Fraxinus rhynchophylla Hance and its components in a mouse model of depressive-like disorder induced by reserpine administration. Front. Behav. Neurosci., 15.","DOI":"10.3389\/fnbeh.2021.650833"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Foudah, A.I., Alqarni, M.H., Alam, A., Devi, S., Salkini, M.A., and Alam, P. (2022). Rutin improves anxiety and reserpine-induced depression in rats. Molecules, 27.","DOI":"10.3390\/molecules27217313"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.1007\/s12035-024-04167-8","article-title":"Pharmacological evidence of Eugenia brasiliensis leaves in a reserpine-induced fibromyalgia model: Antinociceptive, emotional, anti-inflammatory, and neurotrophic effects","volume":"61","author":"Kraus","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10719-020-09942-y","article-title":"130 years of plant lectin research","volume":"37","author":"Tsaneva","year":"2020","journal-title":"Glycoconj. J."},{"key":"ref_9","first-page":"7164","article-title":"The chemical composition and biological activities of essential oil from the fresh leaves of Schinus terebinthifolius from Zimbabwe","volume":"8","author":"Gundidza","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.31482\/mmsl.2017.005","article-title":"Brazilian pepper tree: Review of pharmacology","volume":"86","author":"Patocka","year":"2017","journal-title":"Mil. Med. Sci. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jep.2019.01.011","article-title":"Evaluation of antitumor activity and toxicity of Schinus terebinthifolia leaf extract and lectin (SteLL) in sarcoma 180-bearing mice","volume":"233","author":"Ramos","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"118496","DOI":"10.1016\/j.jep.2024.118496","article-title":"Assessment of acute toxicity, genotoxicity, and anti-inflammatory activity of SteLL, a lectin from Schinus terebinthifolia Raddi. Leaves, in mice","volume":"333","author":"Marinho","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lima, B.R.F., Patriota, L.L.S., Marinho, A.O., Costa, J.A., Napole\u00e3o, T.H., Rosa, M.M., and Paiva, P.M.G. (2022). The anxiolytic activity of Schinus terebinthifolia leaf lectin (SteLL) is dependent on monoaminergic signaling although independent of the carbohydrate-binding domain of the lectin. Pharmaceuticals, 15.","DOI":"10.3390\/ph15111364"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"137092","DOI":"10.1016\/j.neulet.2023.137092","article-title":"The lectin from Schinus terebinthifolia leaf (SteLL) reduces immobility of mice on the tail suspension test dependent on the monoaminergic and nitric oxide signaling","volume":"801","author":"Lima","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119343","DOI":"10.1016\/j.jep.2025.119343","article-title":"Subacute symptoms of depression and anxiety in stress-exposed mice: Role of Schinus terebinthifolia Raddi leaf lectin (SteLL)","volume":"341","author":"Lima","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/jam.12086","article-title":"Antimicrobial lectin from Schinus terebinthifolius leaf","volume":"114","author":"Gomes","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Santos, A.J.C.A., Barros, B.R.S., Aguiar, L.M.S., Patriota, L.L.S., Lima, T.A., Zingali, R.B., Paiva, P.M.G., Napole\u00e3o, T.H., Melo, C.M.L., and Pontual, E.V. (2020). Schinus terebinthifolia leaf lectin (SteLL) is an immunomodulatory agent by altering cytokine release by mice splenocytes. 3 Biotech, 10.","DOI":"10.1007\/s13205-020-2137-2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1515\/hsz-2023-0190","article-title":"Rodent models for mood disorders\u2014Understanding molecular changes by investigating social behavior","volume":"404","author":"Reinhardt","year":"2023","journal-title":"Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/jnc.16097","article-title":"The role of serotonin in depression\u2014A historical roundup and future directions","volume":"168","author":"Bremshey","year":"2024","journal-title":"J. Neurochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/02698811221115762","article-title":"The effects of reserpine on depression: A systematic review","volume":"37","author":"Strawbridge","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41586-023-06926-4","article-title":"Transport and inhibition mechanisms of human VMAT2","volume":"626","author":"Wu","year":"2024","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/jdi.13879","article-title":"Serotonin in the regulation of systemic energy metabolism","volume":"13","author":"Moon","year":"2022","journal-title":"J. Diabetes Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.physbeh.2018.06.032","article-title":"The many facets of dopamine: Toward an integrative theory of the role of dopamine in managing the body\u2019s energy resources","volume":"195","author":"Chakravarthy","year":"2018","journal-title":"Physiol. Behav."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/brain\/awab111","article-title":"The role of noradrenaline in cognition and cognitive disorders","volume":"144","author":"Holland","year":"2021","journal-title":"Brain"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhao, J., Shi, W., Lu, Y., Gao, X., Wang, A., Zhang, S., Du, Y., Wang, Y., and Li, L. (2022). Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-04065-0"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-8994-2_4","article-title":"The Elevated Plus Maze Test for measuring anxiety-like behavior in rodents","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5543320","DOI":"10.1155\/2021\/5543320","article-title":"Antidepressant and anxiolytic effects and subacute toxicity of the aerial parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in murine models","volume":"2021","author":"Armah","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.2174\/0109298665270366231031052629","article-title":"Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice","volume":"30","author":"Patriota","year":"2023","journal-title":"Prot. Pept. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jad.2021.03.029","article-title":"Treatment patterns in patients with treatment-resistant depression in Danish patients with major depressive disorder","volume":"287","author":"Gronemann","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_30","first-page":"369","article-title":"Treatment-resistant depression: Therapeutic trends, challenges, and future directions","volume":"6","year":"2012","journal-title":"Patient Prefer. Adherence"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zheng, G., Xue, W., Wang, P., Yang, F., Li, B., Li, X., Li, Y., Yao, X., and Zhu, F. (2016). Exploring the inhibitory mechanism of approved selective norepinephrine reuptake inhibitors and reboxetine enantiomers by molecular dynamics study. Sci. Rep., 6.","DOI":"10.1038\/srep26883"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/idoj.IDOJ_330_19","article-title":"Update on pharmacotherapy in psychodermatological disorders","volume":"11","author":"Shenoi","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jcsm.12908","article-title":"Prevalence of depression in patients with sarcopenia and correlation between the two diseases: Systematic review and meta-analysis","volume":"13","author":"Li","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zakaria, F.H., Samhani, I., Mustafa, M.Z., and Shafin, N. (2022). Pathophysiology of depression: Stingless bee honey promising as an antidepressant. Molecules, 27.","DOI":"10.3390\/molecules27165091"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12974-020-01922-1","article-title":"Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice","volume":"17","author":"Worthen","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"108624","DOI":"10.1016\/j.pharmthera.2024.108624","article-title":"Immunotherapy for depression: Recent insights and future targets","volume":"257","author":"Bai","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: Hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107322","DOI":"10.1016\/j.phrs.2024.107322","article-title":"\u201cInflamed\u201d depression: A review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression","volume":"207","author":"Yin","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Alami, M., Boumezough, K., Zerif, E., Zoubdane, N., Khalil, A., Bunt, T., Laurent, B., Witkowski, J.M., Ramassamy, C., and Boulbaroud, S. (2024). In vitro assessment of the neuroprotective effects of pomegranate (Punica granatum L.) polyphenols against tau phosphorylation, neuroinflammation, and oxidative stress. Nutrients, 16.","DOI":"10.3390\/nu16213667"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e1132","DOI":"10.1038\/tp.2017.76","article-title":"Immunological effects of behavioral activation with exercise in major depression: An exploratory randomized controlled trial","volume":"7","author":"Euteneuer","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12974-020-01871-9","article-title":"A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment","volume":"17","author":"Zhang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3109\/10253890.2015.1087502","article-title":"Protracted effects of chronic stress on serotonin-dependent thermoregulation","volume":"18","author":"Natarajan","year":"2015","journal-title":"Stress"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2017.06.037","article-title":"Both serotonergic and noradrenergic systems modulate the development of tolerance to chronic stress in rats with lesions of the serotonergic neurons of the median raphe nucleus","volume":"14","author":"Pereira","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0006-3223(99)00127-4","article-title":"Role of norepinephrine in the pathophysiology and treatment of mood disorders","volume":"46","author":"Ressler","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ijbiomac.2017.02.019","article-title":"CasuL: A new lectin isolated from Calliandra surinamensis leaf pinnulae with cytotoxicity to cancer cells, antimicrobial activity and antibiofilm effect","volume":"98","author":"Patriota","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s11064-013-1092-2","article-title":"Antioxidant effects of nerolidol in mice hippocampus after open field test","volume":"38","author":"Neto","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"117415","DOI":"10.1016\/j.jep.2023.117415","article-title":"Antidepressant- and anxiolytic-like activities and acute toxicity evaluation of the Psilocybe cubensis mushroom in experimental models in mice","volume":"320","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"112947","DOI":"10.1016\/j.bbr.2020.112947","article-title":"Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats","volume":"397","author":"Crestani","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1111\/ejn.14409","article-title":"Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test","volume":"50","author":"Sandini","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/asl.ASL_75_17","article-title":"Antianxiety and anti-depressant-like effects of Murraya koenigii in experimental models of anxiety and depression","volume":"36","author":"Sharma","year":"2017","journal-title":"Anc. Sci. Life"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/14\/19\/3048\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T04:11:19Z","timestamp":1759464679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/14\/19\/3048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":52,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["plants14193048"],"URL":"https:\/\/doi.org\/10.3390\/plants14193048","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}