{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:18:17Z","timestamp":1762777097961,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2023-152373OB-I00"],"award-info":[{"award-number":["PID2023-152373OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This study aimed to determine the antifungal activity of various compounds and develop a novel antifungal formulation against fungal pathogens, including Alternaria alternata, Botrytis cinerea, Penicillium expansum, and Rhizopus stolonifer. A total of 32 plant-derived secondary metabolites and three extracts (dichloromethane, ethyl acetate, and methanol) from Lawsonia inermis, Juglans regia, and Drosera intermedia were screened at a concentration of 250 ppm. The chemical composition of the D. intermedia ethyl acetate extract was characterized using chromatographic techniques. Subsequently, an emulsifiable concentrate formulation from this extract was prepared, and its efficacy was evaluated at concentrations ranging from 250 to 2000 ppm. The D. intermedia ethyl acetate extract was found to contain three flavonoids (1.4%) and three naphthoquinones (2.8%). The formulation exhibited optimal effect at 1000 ppm. Overall, the high efficacy of the formulation containing the dried D. intermedia extract (10:1, ethyl acetate) positions it as a promising and viable alternative to synthetic fungicides.<\/jats:p>","DOI":"10.3390\/plants14223427","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:47:27Z","timestamp":1762775247000},"page":"3427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Design of a Plant-Based Biopesticide Formulation with Extracts and Derivatives Containing Naphthoquinones"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-0336","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Calvo","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain"},{"name":"IDISNA-Instituto de Investigaci\u00f3n Biosanitaria de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mincuzzi, A., Sanzani, S.M., Palou, L., Ragni, M., and Ippolito, A. (2022). Postharvest Rot of Pomegranate Fruit in Southern Italy: Characterization of the Main Pathogens. J. Fungi, 8.","DOI":"10.3390\/jof8050475"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100362","DOI":"10.1016\/j.fufo.2024.100362","article-title":"Sustainable development goals through reducing food loss and food waste: A comprehensive review","volume":"9","author":"Manzoor","year":"2024","journal-title":"Future Foods"},{"key":"ref_3","unstructured":"UN (2015). Transforming Our World: The 2030 Agenda for Sustainable Development. Resolution Adopted by the General Assembly on 25 September 2015, United Nations."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Torres, P. (2021). Molecular Mechanisms Underlying Fungicide Resistance in Citrus Postharvest Green Mold. J. Fungi, 7.","DOI":"10.3390\/jof7090783"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fbr.2021.01.003","article-title":"Evolving challenges and strategies for fungal control in the food supply chain","volume":"36","author":"Davies","year":"2021","journal-title":"Fungal Biol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.envint.2015.07.022","article-title":"Occurrence, fate and ecological risk of five typical azole fungicides as therapeutic and personal care products in the environment: A review","volume":"84","author":"Chen","year":"2015","journal-title":"Environ. Int."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Vitiello, A., Ferrara, F., Boccellino, M., Ponzo, A., Cimmino, C., Comberiati, E., Zovi, A., Clemente, S., and Sabbatucci, M. (2023). Antifungal Drug Resistance: An Emergent Health Threat. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041063"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s10924-021-02315-y","article-title":"Natural Biocidal Compounds of Plant Origin as Biodegradable Materials Modifiers","volume":"30","year":"2022","journal-title":"J. Polym. Environ."},{"key":"ref_9","first-page":"79","article-title":"Application of edible coating based on durian seed starch and peel liquid smoke as natural preservatives for tomatoes (Solanum lycopersicum L.)","volume":"54","author":"Faisal","year":"2025","journal-title":"S. Afr. J. Chem. Eng."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41538-025-00477-w","article-title":"Current status and future trends of eco-friendly management of postharvest fungal decays in tomato fruit","volume":"9","author":"Wang","year":"2025","journal-title":"npj Sci. Food"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Alvarez, M.V., P\u00e9rez-Gago, M.B., Taberner, V., Settier-Ram\u00edrez, L., Mart\u00ednez-Blay, V., and Palou, L. (2023). Postharvest Application of Novel Bio-Based Antifungal Composite Edible Coatings to Reduce Sour Rot and Quality Losses of \u2018Valencia\u2019 Oranges. Coatings, 13.","DOI":"10.3390\/coatings13081412"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Matrose, N.A., Obikeze, K., Belay, Z.A., and Caleb, O.J. (2021). Plant extracts and other natural compounds as alternatives for post-harvest management of fruit fungal pathogens: A review. Food Biosci., 41.","DOI":"10.1016\/j.fbio.2020.100840"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1007\/s11164-024-05354-x","article-title":"Novel pyrazoline-thiazole hybrids containing azo group as antibacterial agents: Design, synthesis, in vitro bioactivity, in silico molecular docking, ADME profile and DFT studies","volume":"50","author":"Hussein","year":"2024","journal-title":"Res. Chem. Intermed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.36253\/ahsc-14691","article-title":"Efficacy of active and passive modified atmosphere packaging on quality preservation and storage life of pomegranate fruit and arils: A review","volume":"38","author":"Moradinezhad","year":"2024","journal-title":"Adv. Hort. Sci."},{"key":"ref_15","first-page":"1","article-title":"Phenolic compounds and their antimicrobial activities","volume":"7","author":"Silva","year":"2017","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100262","DOI":"10.1016\/j.prmcm.2023.100262","article-title":"Antifungal natural products and their derivatives: A review of their activity and mechanism of actions","volume":"7","author":"Zhang","year":"2023","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ptr.5823","article-title":"Antifungal Activity of Gallic Acid In Vitro and In Vivo","volume":"31","author":"Li","year":"2017","journal-title":"Phytother Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.funbio.2017.09.002","article-title":"Evaluating the response to Fusarium ananatum inoculation and antifungal activity of phenolic acids in pineapple","volume":"121","author":"Barral","year":"2017","journal-title":"Fungal Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/jam.13540","article-title":"Alteration of oxidative phosphorylation as a possible mechanism of the antifungal action of p-coumaric acid against Botrytis cinerea","volume":"123","author":"Morales","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1021\/acs.jafc.9b00087","article-title":"Defense Responses, Induced by p-Coumaric Acid and Methyl p-Coumarate, of Jujube (Ziziphus jujuba Mill.) Fruit against Black Spot Rot Caused by Alternaria alternata","volume":"67","author":"Yuan","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Alfarrayeh, I., Poll\u00e1k, E., Cz\u00e9h, \u00c1., Vida, A., Das, S., and Papp, G. (2021). Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different Candida Species. Antibiotics, 10.","DOI":"10.3390\/antibiotics10111359"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000491755","article-title":"Antioxidant Properties of Ferulic Acid and Its Possible Application","volume":"31","author":"Dana","year":"2018","journal-title":"Skin Pharmacol Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.17221\/178\/2021-CJFS","article-title":"Coumarin Derivatives as Antifungal Agents\u2014A Review","volume":"41","author":"Molnar","year":"2023","journal-title":"Czech J. Food Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejmech.2015.11.027","article-title":"Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents","volume":"108","author":"Ji","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/ijms14011293","article-title":"Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity","volume":"14","author":"Guerra","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Al Aboody, M.S., and Mickymaray, S. (2020). Anti-Fungal Efficacy and Mechanisms of Flavonoids. Antibiotics, 9.","DOI":"10.3390\/antibiotics9020045"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41429-020-0280-y","article-title":"Ferrocenyl chalcone derivatives as possible antimicrobial agents","volume":"73","author":"Henry","year":"2020","journal-title":"J. Antibiot."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.postharvbio.2018.08.005","article-title":"Maturity, storage and ripening effects on anti-fungal compounds in the skin of \u2018Hass\u2019 avocado fruit","volume":"146","author":"Bowen","year":"2018","journal-title":"Postharvest Biol. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Duarte, S., Magro, A., Tom\u00e1s, J., Hil\u00e1rio, C., Ferreira, R.B., and Carvalho, M.O. (2022). Antifungal Activity of Benzoquinones Produced by Tribolium castaneum in Maize-Associated Fungi. Insects, 13.","DOI":"10.3390\/insects13100868"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Navarro-Tovar, G., Vega-Rodr\u00edguez, S., Leyva, E., Loredo-Carrillo, S., de Loera, D., and L\u00f3pez-L\u00f3pez, L.I. (2023). The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review. Pharmaceuticals, 16.","DOI":"10.3390\/ph16040496"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e202203330","DOI":"10.1002\/slct.202203330","article-title":"1,4-Naphthoquinone Analogs and Their Application as Antibacterial Agents","volume":"7","author":"Wang","year":"2022","journal-title":"ChemistrySelect"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1590\/0001-3765201820170815","article-title":"The Antifungal Activity of Naphthoquinones: An Integrative Review","volume":"90","author":"Futuro","year":"2018","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1002\/ps.6989","article-title":"Anthraquinones and their analogues as potential biocontrol agents of rust and powdery mildew diseases of field crops","volume":"78","author":"Barilli","year":"2022","journal-title":"Pest. Manag. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e202204537","DOI":"10.1002\/slct.202204537","article-title":"Exploring Anthraquinones as Antibacterial and Antifungal Agents","volume":"8","author":"Raghuveer","year":"2023","journal-title":"ChemistrySelect"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"116249","DOI":"10.1016\/j.ejmech.2024.116249","article-title":"Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties","volume":"268","author":"Plano","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rahman, M.M., Islam, M.R., Akash, S., Shohag, S., Ahmed, L., Supti, F.A., Rauf, A., Aljohani, A.S.M., Al Abdulmonem, W., and Khalil, A.A. (2022). Naphthoquinones and derivatives as potential anticancer agents: An updated review. Chem. Biol. Interact., 368.","DOI":"10.1016\/j.cbi.2022.110198"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2174\/1568026622666220912101332","article-title":"Mechanism of Action and Implication of Naphthoquinone as Potent Anti-trypanosomal Drugs","volume":"22","author":"Rani","year":"2022","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s11418-018-1221-y","article-title":"Comparison of lawsone contents among Lawsonia inermis plant parts and neurite outgrowth accelerators from branches","volume":"72","author":"Oda","year":"2018","journal-title":"J. Nat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s00210-023-02735-8","article-title":"Therapeutic potential of Lawsonia inermis Linn: A comprehensive overview","volume":"397","author":"Batiha","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_40","first-page":"11","article-title":"Lawsonia inermis L. Phytopharmacological Characteristics and Recent Advancement","volume":"15","author":"Muheyuddeen","year":"2023","journal-title":"Res. J. Pharmacogn. Phytochem."},{"key":"ref_41","first-page":"1934578X241262156","article-title":"Traditional Applications, Ethnopharmacology, and Phytochemistry of Walnut Green Husk (Juglans regia L.): A Review","volume":"19","author":"Li","year":"2024","journal-title":"Nat. Prod. Commun."},{"key":"ref_42","first-page":"1063","article-title":"Evaluation of the antioxidant and antimicrobial properties of in vitro cultured Drosera intermedia extracts","volume":"4","author":"Grevenstuk","year":"2009","journal-title":"Nat. Prod. Commun."},{"key":"ref_43","unstructured":"Parachur, V.A., and Ravichandran, S. (2025, July 21). Patent on the Ethyl Acetate Extracts or Active Ingredients Isolated from Ethyl Acetate Extract of Lawsonia inermis Against Fungal Infections. Available online: https:\/\/patentimages.storage.googleapis.com\/a8\/1c\/9f\/ade52b2d22f1c4\/US20170042955A1.pdf."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"820","DOI":"10.21786\/bbrc\/12.3\/40","article-title":"Antiangiogenic Potential of Endophytic Fungi Alternaria alternata Isolated From Lawsonia inermis Linn","volume":"12","author":"Bendre","year":"2019","journal-title":"Biosci. Biotechnol. Res. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/1750-3841.16473","article-title":"Antioxidant and antimicrobial characteristics of ethyl acetate polar fractions from walnut green husk","volume":"88","author":"Xi","year":"2023","journal-title":"J. Food Sci."},{"key":"ref_46","first-page":"7","article-title":"Comparison of the effects of Juglans nigra green husk and clotrimazole on Candida albicans in rats","volume":"11","author":"Abedi","year":"2018","journal-title":"Jundishapur J. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/jsfa.5522","article-title":"Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi","volume":"92","author":"Grevenstuk","year":"2012","journal-title":"J. Sci. Food Agric."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ahmad, M., Tahir, M., Hong, Z., Zia, M.A., Rafeeq, H., Ahmad, M.S., Rehman, S.U., and Sun, J. (2025). Plant and marine-derived natural products: Sustainable pathways for future drug discovery and therapeutic development. Front. Pharmacol., 6.","DOI":"10.3389\/fphar.2024.1497668"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Anand, U., Jacobo-Herrera, N., Altemimi, A., and Lakhssassi, N. (2019). A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery. Metabolites, 9.","DOI":"10.3390\/metabo9110258"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13020-025-01075-4","article-title":"A new paradigm for drug discovery in the treatment of complex diseases: Drug discovery and optimization","volume":"20","author":"Yuan","year":"2025","journal-title":"Chin. Med."},{"key":"ref_51","unstructured":"National Center for Biotechnology Information (2025a) (2025, July 22). PubChem Compound Summary for CID 10205, Plumbagin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Plumbagin."},{"key":"ref_52","unstructured":"National Center for Biotechnology Information (2025b) (2025, July 22). PubChem Compound Summary for CID 26905, 7-Methyljuglone, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/7-Methyljuglone."},{"key":"ref_53","unstructured":"National Center for Biotechnology Information (2025c) (2025, July 22). PubChem Compound Summary for CID 5281672, Myricetin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Myricetin."},{"key":"ref_54","unstructured":"National Center for Biotechnology Information (2025d) (2025, July 22). PubChem Compound Summary for CID 5280343, Quercetin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Quercetin."},{"key":"ref_55","unstructured":"National Center for Biotechnology Information (2025e) (2025, July 22). PubChem Compound Summary for CID 5280863, Kaempferol, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Kaempferol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.19189\/MAP.2016.OMB.228","article-title":"The Production of 7-Methyljuglone, Plumbagin and Quercetin in Wild and Cultivated Drosera rotundifolia and Drosera intermedia","volume":"18","author":"Baranyai","year":"2016","journal-title":"Mires Peat"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jchromb.2013.06.015","article-title":"LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata","volume":"932","author":"Braunberger","year":"2013","journal-title":"J. Chromatogr. B Analyt Technol. Biomed. Life Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Schlauer, J., Fleischmann, A., Hartmeyer, S.R.H., Hartmeyer, I., and Rischer, H. (2024). Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility. Biology, 13.","DOI":"10.3390\/biology13020097"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"W\u00f3jciak, M., Feldo, M., Stolarczyk, P., and P\u0142achno, B.J. (2023). Carnivorous Plants from Nepenthaceae and Droseraceae as a Source of Secondary Metabolites. Molecules, 28.","DOI":"10.3390\/molecules28052155"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"PA-34","DOI":"10.1055\/s-0029-1234359","article-title":"Identification of antimicrobial agents from Drosera intermedia using HPLC-MS\/HPLC-SPE-NMR","volume":"75","author":"Grevenstuk","year":"2009","journal-title":"Planta Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Liyanapathiranage, A., Dassanayake, R.S., Gamage, A., Karri, R.R., Manamperi, A., Evon, P., Jayakodi, Y., Madhujith, T., and Merah, O. (2023). Recent Developments in Edible Films and Coatings for Fruits and Vegetables. Coatings, 13.","DOI":"10.20944\/preprints202305.2142.v1"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101201","DOI":"10.1016\/j.cscee.2025.101201","article-title":"Stability Studies of Neem Seed Oil-in-Water Emulsion Formulation","volume":"11","author":"Piluharto","year":"2025","journal-title":"Case Stud. Chem. Environ. Eng."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Perez-Vazquez, A., Barciela, P., Carpena, M., and Prieto, M.A. (2023). Edible Coatings as a Natural Packaging System to Improve Fruit and Vegetable Shelf Life and Quality. Foods, 12.","DOI":"10.3390\/foods12193570"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodhyd.2014.10.024","article-title":"Influence of xanthan gum on oil-in-water emulsion characteristics stabilized by OSA starch","volume":"45","year":"2015","journal-title":"Food Hydrocoll."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Baptista, S., Baptista, F., and Freitas, F. (2023). Development of Emulsions Containing L-Ascorbic Acid and \u03b1-Tocopherol Based on the Polysaccharide FucoPol: Stability Evaluation and Rheological and Texture Assessment. Cosmetics, 10.","DOI":"10.3390\/cosmetics10020056"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"100118","DOI":"10.1016\/j.jfp.2023.100118","article-title":"Evaluation of Sodium Benzoate and Potassium Sorbate Preservative Concentrations in Different Sauce Samples in Urmia, Iran","volume":"86","author":"Yazdanfar","year":"2023","journal-title":"J. Food Prot."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Benamar, K., Lahlali, R., Ezzouggari, R., El Ouassete, M., Dehbi, I., Khadiri, M., Radi, M., Ait Haddou, L., Ibnsouda Koraichi, S., and Benamar, S. (2025). Antifungal Efficacy of Ethanolic Extracts from Four Medicinal Plants Against Major Postharvest Fungal Pathogens of Apple Fruit. Agronomy, 15.","DOI":"10.3390\/agronomy15071577"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Khadiri, M., Boubaker, H., Askarne, L., Farhaoui, A., Taoussi, M., Haddou, L.A., Cherrate, M., Ouchari, W., Zerrouk, M.H., and Sobeh, M. (2024). Exploration of the antifungal potential of aqueous extracts from two agave species against major postharvest diseases in apples. Postharvest Biol. Technol., 214.","DOI":"10.1016\/j.postharvbio.2024.112992"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Nawaz, M., Pan, J., Liu, H., Umer, M.J., Liu, J., Yang, W., Lv, Z., Zhang, Q., and Jiao, Z. (2025). Integrated evaluation of antifungal activity of pomegranate peel polyphenols against a diverse range of postharvest fruit pathogens. Bioresour. Bioprocess., 12.","DOI":"10.1186\/s40643-025-00874-9"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s13197-019-03747-0","article-title":"Antifungal activity of thymol and carvacrol against postharvest pathogens Botrytis cinerea","volume":"56","author":"Zhang","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"ref_71","first-page":"382","article-title":"Antibacterial, antifungal activity and chemical composition study of essential oil of Mentha piperita from the south Algerian","volume":"7","author":"Mehani","year":"2015","journal-title":"Der Pharma Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodcont.2018.01.018","article-title":"Nanoencapsulation: An efficient technology to boost the antimicrobial potential of plant essential oils in food system","volume":"89","author":"Prakash","year":"2018","journal-title":"Food Control"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.sajb.2024.04.027","article-title":"Neem (Azadirachta indica) Seed Extract Formulation for Managing Anthracnose and Gray Mold Diseases in Strawberry","volume":"169","author":"Motallebi","year":"2024","journal-title":"S. Afr. J. Bot."},{"key":"ref_74","first-page":"100013","article-title":"Formulation and development of lipid nanoparticle antifungal packaging films to control postharvest disease","volume":"1","author":"McDaniel","year":"2019","journal-title":"J. Agric. Food Res."},{"key":"ref_75","first-page":"102280","article-title":"Harnessing plant-derived antifungal agents and nanoencapsulation for postharvest pathogen management: A comprehensive review","volume":"24","author":"Arouiee","year":"2025","journal-title":"J. Agric. Food Res."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhang, X., Sun, M., Wang, L., Zou, Y., Fu, L., Han, C., Li, A., Li, L., and Zhu, C. (2022). Impact of vanillin on postharvest disease control of apple. Front Microbiol., 13.","DOI":"10.3389\/fmicb.2022.979737"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11130-008-0073-0","article-title":"Antioxidant and Antifungal Activity of Verbena officinalis L. Leaves","volume":"63","author":"Casanova","year":"2008","journal-title":"Plant Foods Hum. Nutr."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/14\/22\/3427\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:14:13Z","timestamp":1762776853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/14\/22\/3427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,9]]},"references-count":77,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["plants14223427"],"URL":"https:\/\/doi.org\/10.3390\/plants14223427","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,9]]}}}