{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:03:02Z","timestamp":1773900182392,"version":"3.50.1"},"reference-count":71,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["#406690\/2023-5"],"award-info":[{"award-number":["#406690\/2023-5"]}]},{"name":"CNPQ","award":["312252\/2025-0"],"award-info":[{"award-number":["312252\/2025-0"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES","award":["# 88887.857033\/2023-00"],"award-info":[{"award-number":["# 88887.857033\/2023-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Type 2 diabetes mellitus remains a major global health challenge, and natural hypoglycemic compounds are of increasing interest. Aqueous extracts from five Brazilian medicinal plants (Lippia origanoides Kunth, Amburana cearensis (Allem\u00e3o) A.C. Smith, Justicia pectoralis Jacq., Libidibia ferrea (Mart. ex Tul.) L.P. Queiroz, and Spondias mombin L.) were evaluated for \u03b1-glucosidase and intestinal disaccharidase inhibition; next, they were chemically profiled by UPLC-HRMS. Extracts of L. origanoides, A. cearensis, and J. pectoralis exhibited the strongest activities, attributed to flavonoids, iridoid and cinnamic acid derivatives, phenolic acids, and saponins. Molecular docking identified hyperoside, eudesmic acid and isoquercitrin as their main \u03b1-glucosidase inhibitors, respectively. In vitro testing confirmed that isoquercitrin effectively inhibited \u03b1-glucosidase (IC50 = 0.09 mg mL\u22121), showing stronger activity than acarbose. ADME simulations indicated low gastrointestinal absorption but favorable intestinal enzyme-targeted properties, consistent with their pharmacological profiles. Acute toxicity in zebrafish showed low toxicity for L. origanoides and A. cearensis and moderate levels for J. pectoralis, supporting their overall safety. These findings highlight these species as promising sources of bioactive compounds for developing safe, plant-based antidiabetic agents.<\/jats:p>","DOI":"10.3390\/plants14223517","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:05:31Z","timestamp":1763463931000},"page":"3517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Searching for Hypoglycemic Compounds from Brazilian Medicinal Plants Through UPLC-HRMS and Molecular Docking"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-4110","authenticated-orcid":false,"given":"Elisabeth Mariano","family":"Batista","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal do Cear\u00e1, Campus Pici, Fortaleza 60356-000, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4156-5222","authenticated-orcid":false,"given":"Gabriela Ara\u00fajo","family":"Freire","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina, Departamento de Farmacologia e Fisiologia, N\u00facleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3139","authenticated-orcid":false,"given":"Caio Bruno Rodrigues","family":"Martins","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina, Departamento de Farmacologia e Fisiologia, N\u00facleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Cear\u00e1, Fortaleza 60430-275, CE, 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8340-4876","authenticated-orcid":false,"given":"Nylane Maria Nunes de","family":"Alencar","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina, Departamento de Farmacologia e Fisiologia, N\u00facleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-4015","authenticated-orcid":false,"given":"Paulo Riceli Vasconcelos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical, Fortaleza 60020-181, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8816-4258","authenticated-orcid":false,"given":"Natalia 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