{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:20:58Z","timestamp":1792038058348,"version":"4.4.0"},"reference-count":129,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The Belamcanda chinensis (L.) Redout\u00e9 is a perennial herb belong to the genus Belamcanda, primarily found in China, but with additional distribution in North Korea, South Korea, Japan, and India. The rhizomes of B. chinensis have a long history of use as a traditional herbal medicine in China, one that is recognized for its effects in clearing heat, in detoxifying and eliminating phlegm, and in soothing the throat. In this review, we conducted a comprehensive search across several databases, both Chinese and international, using the primary keyword Belamcanda chinensis paired with a relevant research area (e.g., chemical composition, pharmacology). The databases included Sci-Finder, ScienceDirect, PubMed, China National Knowledge Infrastructure, Wiley, Springer Baidu Scholar and Research Gate, as well as domestic materia medica. We illustrated the chemical structures using ChemBioDraw Ultra 22.0 software. There are more than 10 proprietary Chinese medicines already on the market that consist of or originate from B. chinensis. More than 200 natural products have been isolated and identified from B. chinensis, including iridal-type triterpenoids, flavonoids, phenolics, quinones, sesquiterpenes, and polysaccharides. Modern pharmacological studies indicate that both crude extracts and monomeric compounds exhibit anti-inflammatory, anti-tumor, antioxidant, neuroprotective and anti-diabetic activities, with potential regulatory pathways. Additionally, B. chinensis demonstrates toxicity to fish, mollusks and arthropods. Clinical studies have shown that formulas containing B. chinensis as the main ingredient have a good therapeutic effect on respiratory diseases. In summary, B. chinensis presents promising prospects for application in medicine, functional food, cosmetics and agriculture. Therefore, we have reviewed the chemical composition, pharmacological activities (both in vivo and in vitro), structure\u2013activity relationships, toxicity and clinical application of B. chinensis over the past 40 years, aiming to provide a theoretical basis for the subsequent comprehensive utilization of the plants.<\/jats:p>","DOI":"10.3390\/plants14233688","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T16:47:37Z","timestamp":1764780457000},"page":"3688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of Belamcanda chinensis: A Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Tieqiang","family":"Zong","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0874-5420","authenticated-orcid":false,"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqi","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-8859","authenticated-orcid":false,"given":"Gao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"ref_1","unstructured":"Flora of China Editorial Committee (1985). Flora of China. Flora of China Vol.16, Science Press & Missouri Botanical Garden Press."},{"key":"ref_2","first-page":"2728","article-title":"Textual Research of Prescription Application of Belamcanda chinensis","volume":"34","author":"Wang","year":"2016","journal-title":"Zhonghua Zhongyiyao Xuekan"},{"key":"ref_3","first-page":"846","article-title":"Textual Research on Traditional Effect Verification of Belamcanda chinensis and Its Pharmacological Experimental Verification","volume":"19","author":"Wen","year":"2017","journal-title":"World Sci. Technol. Mod. Tradit. Chin. Med. Mater. Med."},{"key":"ref_4","first-page":"138","article-title":"Multi-center clinical trial of Shegan Liyan oral liquid in treating acute infantile pharyngitis with intenseness of heat in lung and stomach","volume":"31","author":"Xu","year":"2014","journal-title":"Tianjin J. Tradit. Chin. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/np980271b","article-title":"Iridal-type triterpenoids with ichthyotoxic activity from Belamcanda chinensis","volume":"62","author":"Ito","year":"1999","journal-title":"J. Nat. Prod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/carcin\/bgi092","article-title":"Tectorigenin and other phytochemicals extracted from leopard lily Belamcanda chinensis affect new and established targets for therapies in prostate cancer","volume":"26","author":"Thelen","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref_7","first-page":"1712","article-title":"Separation and Antioxidant Activity of Belamcanda Chinensis\u2019s Effective Components in Anti-inflammatory and cough","volume":"41","author":"Zhang","year":"2014","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF02980104","article-title":"Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats","volume":"27","author":"Jung","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"ref_9","unstructured":"Li, S.L. (2018). Study on the Separation, Extraction and In Vitro Activity of the Isoflavonoids from Belamcanda chinensis. [Master\u2019s Thesis, Changchun Normal University]."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhao, Y.N., Wang, X.L., Li, Y.L., Liu, Y.H., Hou, J.T., and Guo, Y.Q. (2024). Preparation and photothermal therapy of gold nanorods modified by Belamcanda chinensis (L.) DC polysaccharide. Int. J. Biol. Macromol., 255.","DOI":"10.1016\/j.ijbiomac.2023.127854"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121831","DOI":"10.1016\/j.carbpol.2024.121831","article-title":"An arabinose-rich heteropolysaccharide isolated from Belamcanda chinensis (L.) DC treats liver cancer by targeting FAK and activating CD40","volume":"331","author":"Zhao","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Duan, Y.Q., Sun, J.F., Xue, Y.K., Xu, W.W., Jiang, Y.X., Zong, T.Q., Zhou, W., Hu, Z.Y., and Li, G. (2025). Physicochemical Properties and Cytoprotective Effects on PC12 Cells of Polysaccharides from Belamcanda chinensis (L.) DC. Obtained via a Gradient Ethanol Precipitation Method. Molecules, 30.","DOI":"10.3390\/molecules30050998"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Duan, Y.Q., Hu, Z.Y., Jin, L., Zong, T.Q., Huang, Y.Y., Sun, J.F., Zhou, W., and Li, G. (2022). Isolation, Characterization and Anticomplementary Activity of Polysaccharides from the Rhizomes of Belamcanda chinensis (L.) DC. Chem. Biodivers., 19.","DOI":"10.1002\/cbdv.202200525"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Guo, Y.P., Yi, P., Shi, Q.Q., Yu, R.R., Wang, J.H., Li, C.Y., and Wu, H.Q. (2023). Cytotoxic Compounds from Belamcanda chinensis (L.) DC Induced Apoptosis in Triple-Negative Breast Cancer Cells. Molecules, 28.","DOI":"10.3390\/molecules28124715"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.biopha.2018.11.094","article-title":"Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-A(y) mice","volume":"110","author":"Guo","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_16","unstructured":"Qian, S.Y.H. (2024). Study on Chemical Constituents and Biological Activities of Belamcanda chinensis. [Master\u2019s Thesis, Guizhou University]."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Song, Y.Y., Jiang, J.B., Yan, Y.M., and Cheng, Y.X. (2021). Isolation and identification of belamcandaoids A-N from Belamcanda chinensis seeds and their inhibition on extracellular matrix in TGF-\u03b21 induced kidney proximal tubular cells. Bioorg. Chem., 114.","DOI":"10.1016\/j.bioorg.2021.105067"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1248\/cpb.c18-00645","article-title":"Four New Compounds Isolated from the Aerial Part of Belamcanda chinensis (L.) and Their Effect on Vascular Smooth Muscle Cell (VSMC) Proliferation","volume":"67","author":"Ha","year":"2019","journal-title":"Chem. Pharm. Bull."},{"key":"ref_19","unstructured":"Li, G.X. (2008). Study on the Therapeutic Basis of Traditional Chinese Medicinal preparation Belamcanda chinensis About Bacteriostasis, Antiinflammation, Astopping Cough Effect and Pharamcokinetics of Related Elements. [Doctoral Dissertation, Liaoning University of Traditional Chinese Medicine]."},{"key":"ref_20","first-page":"1460","article-title":"Effects of tectoridinon Th17\/Treg balance in mice with psoriasis","volume":"44","author":"Pei","year":"2022","journal-title":"Chin. Tradit. Pat. Med."},{"key":"ref_21","first-page":"85","article-title":"Effect of Shegan Mahuang Decoction combined with salbutamol in thetreatment of elderly patients with acute attack of bronchial asthma and its influence on respiratory function","volume":"37","author":"Cai","year":"2021","journal-title":"Chin. Community Dr."},{"key":"ref_22","first-page":"633","article-title":"Clinical Observation of Shegan Mahuang Decoction in the treatment of Acute Attack of Bronchial Asthma","volume":"37","author":"Fang","year":"2022","journal-title":"Guangming J. Chin. Med."},{"key":"ref_23","first-page":"66","article-title":"Classical Prescription in the Treatment of Cough Variant Asthmn","volume":"22","author":"Li","year":"2024","journal-title":"Chin. Med. Mod. Distance Educ."},{"key":"ref_24","first-page":"1108","article-title":"Analysis of the Treatment of PCT Patients with Inflammatory Conditions and Sheganmahuang Decoction in Acute Attack of Senile Chronic Bronchitis","volume":"31","author":"Liu","year":"2019","journal-title":"Clin. J. Tradit. Chin. Med."},{"key":"ref_25","first-page":"200","article-title":"Clinical Observation on Shegan Mahuang Decoction in the Treatment of Syndrome of Cold Fluid Retained in Lung of Acute Exacerbation Chronic Obstructive Pulmonary Disease","volume":"18","author":"Zhu","year":"2020","journal-title":"Chin. Med. Mod. Distance Educ."},{"key":"ref_26","unstructured":"Wang, Z.S., and Xue, H. (2008). Shen Nong Ben cao Jing, Sichuan Science and Technology Press. [Critical Edition ed.]."},{"key":"ref_27","unstructured":"Tao, H. (1986). Ming Yi Bie Lu, People\u2019s Medical Publishing House."},{"key":"ref_28","unstructured":"Ge, H. (2011). Zhouhou Beiji Fang, Tianjin Science and Technology Press."},{"key":"ref_29","unstructured":"Lu, Z. (1997). Qianjin Yi Fang, Liaoning Science and Technology Press. [Critical Edition ed.]."},{"key":"ref_30","unstructured":"Wang, Z. (2007). Shanghan Zongbing Lun, People\u2019s Medical Publishing House. [Critical Edition ed.]."},{"key":"ref_31","unstructured":"Zhao, J. (1987). Shengji Zonglu, People\u2019s Medical Publishing House. [Facsimile Edition ed.]."},{"key":"ref_32","unstructured":"Liu, H. (2004). Bencao Gangmu, People\u2019s Medical Publishing House. [Critical Edition ed.]."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jmgm.2011.01.001","article-title":"QSAR study of natural estrogen-like isoflavonoids and diphenolics from Thai medicinal plants","volume":"29","author":"Umehara","year":"2011","journal-title":"J. Mol. Graph. Model."},{"key":"ref_34","first-page":"2184","article-title":"Discussion on Clinical Application of Blackberry Lily Rhizome and Its Prescription","volume":"33","author":"Lian","year":"2018","journal-title":"Acta Chin. Med."},{"key":"ref_35","unstructured":"Chinese Pharmacopoeia Commission (2020). Pharmacopoeia of the People\u2019s Republic of China, China Medical Science Press. [2020 Edition ed.]."},{"key":"ref_36","unstructured":"He, R. (2012). Jingui Yaolue Fanglun, People\u2019s Medical Publishing House. [Critical Edition ed.]."},{"key":"ref_37","unstructured":"Gao, W. (1957). WaiTai MiYao, People\u2019s Medical Publishing House. [Facsimile Edition ed.]."},{"key":"ref_38","unstructured":"Wang, H.Y. (1958). TaiPing ShengHui Fang, People\u2019s Medical Publishing House. [Critical Reprint Edition ed.]."},{"key":"ref_39","unstructured":"Chen, W.Z. (1995). Xiao Er Dou Zhen Fang Lun, People\u2019s Medical Publishing House. [Critical Edition ed.]."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bioorg.2018.08.039","article-title":"New iridal-type triterpenoid derivatives with cytotoxic activities from Belamcanda chinensis","volume":"83","author":"Li","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"20160","DOI":"10.1039\/C7RA00614D","article-title":"The unprecedented iridal lactone and adducts of spiroiridal and isoflavonoid from Belamcanda chinensis","volume":"7","author":"Ni","year":"2017","journal-title":"RSC Adv."},{"key":"ref_42","unstructured":"Yi, P. (2023). Identification and Effect Evaluation of Active Ingredients in Belamcanda chinensis Anti-Triple-Negative Breast Cancer. [Master\u2019s Thesis, Shenzhen University]."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Ban, Y.J., Baiseitova, A., Nyiramana, M.M., Kang, S.S., Kang, D., and Park, K.H. (2021). Iridal-Type Triterpenoids Displaying Human Neutrophil Elastase Inhibition and Anti-Inflammatory Effects from Belamcanda chinensis. Molecules, 26.","DOI":"10.3390\/molecules26216602"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1039\/C8OB00789F","article-title":"Belamchinenin A, an unprecedented tricyclic-fused triterpenoid with cytotoxicity from Belamcanda chinensis","volume":"16","author":"Ni","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105040","DOI":"10.1016\/j.fitote.2021.105040","article-title":"New iridal-type triterpenoid analogues with 6\/5\/6-fused carbon skeleton from the rhizomes of Belamcanda chinensis","volume":"157","author":"Li","year":"2022","journal-title":"Fitoterapia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tetlet.2017.12.013","article-title":"Belamcandanes A and B, two unprecedented tricyclic-iridal triterpenoids from Belamcanda chinensis","volume":"59","author":"Ni","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1021\/acs.jnatprod.8b00993","article-title":"Iridal-Type Triterpenoids with a Cyclopentane Unit from the Rhizomes of Belamcanda chinensis","volume":"82","author":"Li","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1021\/acs.orglett.8b02490","article-title":"Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis","volume":"20","author":"Song","year":"2018","journal-title":"Org. Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.3390\/molecules17056156","article-title":"Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities","volume":"17","author":"Liu","year":"2012","journal-title":"Molecules"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/ol102796k","article-title":"A new dimeric iridal triterpenoid from Belamcanda chinensis with significant molluscicide activity","volume":"13","author":"Song","year":"2011","journal-title":"Org. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s12272-014-0529-8","article-title":"Chemical constituents from Belamcanda chinensis and their inhibitory effects on nitric oxide production in RAW 264.7 macrophage cells","volume":"38","author":"Lee","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpba.2014.05.008","article-title":"Phenolic metabolite profiles and antioxidants assay of three Iridaceae medicinal plants for traditional Chinese medicine \u201cShe-gan\u201d by on-line HPLC-DAD coupled with chemiluminescence (CL) and ESI-Q-TOF-MS\/MS","volume":"98","author":"Xie","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_53","first-page":"110","article-title":"The \u03b1-Glucosidase Inhibiting Isoflavones Isolated from Belamcanda chinensis Leaf Extract","volume":"6","author":"Wu","year":"2012","journal-title":"Rec. Nat. Prod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.phymed.2004.01.003","article-title":"Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities","volume":"11","author":"Hesse","year":"2004","journal-title":"Phytomedicine"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Song, Y.Y., Liu, Y., Yan, Y.M., Lu, X., and Cheng, Y.X. (2018). Phenolic Compounds from Belamcanda chinensis Seeds. Molecules, 23.","DOI":"10.3390\/molecules23030580"},{"key":"ref_56","unstructured":"Kimutai, F. (2021). Study on the Chemical Constituents of Belamcanda chinensis and Their Antioxidant and Anti-Inflammatory Activities. [Master\u2019s Thesis, University of Chinese Academy of Sciences]."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s10600-007-0235-6","article-title":"Phenolic constituents of Belamcanda chinensis","volume":"43","author":"Jin","year":"2007","journal-title":"Chem. Nat. Compd."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1021\/np040175c","article-title":"Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines","volume":"68","author":"Monthakantirat","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11418-007-0147-6","article-title":"New isoflavones from Belamcandae Rhizoma","volume":"61","author":"Moriyasu","year":"2007","journal-title":"J. Nat. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1111\/j.1744-7909.2005.00142.x","article-title":"A New Isoflavonoid from Belamcanda chinensis (L.) DC","volume":"47","author":"Qin","year":"2005","journal-title":"J. Integr. Plant Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9640","DOI":"10.1039\/D3OB01724A","article-title":"Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis\u2020\u2020Electronic supplementary information (ESI) available","volume":"21","author":"Qian","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.phytol.2019.02.006","article-title":"Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma","volume":"30","author":"Pecio","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"113370","DOI":"10.1016\/j.phytochem.2022.113370","article-title":"Phenolic constituents with anti-inflammatory and cytotoxic activities from the rhizomes of Iris domestica","volume":"203","author":"Liu","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_64","first-page":"1133","article-title":"Studies on Chemical Constituents of Belamcanda chinensis","volume":"41","author":"Qiu","year":"2006","journal-title":"Chin. Pharm. J."},{"key":"ref_65","first-page":"435","article-title":"Study on chemical constituents from Belamcanda chinensis","volume":"31","author":"Zhang","year":"2011","journal-title":"Chin. J. Hosp. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cclet.2006.12.031","article-title":"New flavone and isoflavone glycoside from Belamcanda chinensis","volume":"18","author":"Jin","year":"2007","journal-title":"Chin. Chem. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jpba.2011.05.040","article-title":"Characterization and determination of the major constituents in Belamcandae Rhizoma by HPLC\u2013DAD\u2013ESI-MSn","volume":"56","author":"Zhang","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1248\/cpb.49.1229","article-title":"Isoflavonoids from Belamcanda chinensis","volume":"49","author":"Ito","year":"2001","journal-title":"Chem. Pharm. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zong, T.Q., Cui, L.T., Sun, J.F., Hu, Z.Y., Yang, P.C., Li, M.X., Jin, M., Zhou, W., and Li, G. (2024). Two new phenolic glycosides from the roots of Iris domestica (L.) Goldblatt & Mabb and their cytotoxic activity. Nat. Prod. Res., 1\u20139.","DOI":"10.1080\/14786419.2024.2404659"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3724\/SP.J.1008.2010.01120","article-title":"Studies on chemical constituents of Belamcanda chinensis","volume":"31","author":"Feng","year":"2010","journal-title":"J. Second Mil. Med. Univ."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.talanta.2014.07.004","article-title":"Tissue-specific metabolites profiling and quantitative analyses of flavonoids in the rhizome of Belamcanda chinensis by combining laser-microdissection with UHPLC-Q\/TOF-MS and UHPLC-QqQ-MS","volume":"130","author":"Chen","year":"2014","journal-title":"Talanta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1248\/cpb.39.1877","article-title":"Structures of Belamcandols A and B Isolated from the Seed of Belamcanda chinensis","volume":"39","author":"Fukuyama","year":"1991","journal-title":"Chem. Pharm. Bull."},{"key":"ref_73","first-page":"491","article-title":"Toxicity Componential Analysis of Belamcanda Chinensis (L.)DC","volume":"42","author":"Liu","year":"2011","journal-title":"J. Shenyang Agric. Univ."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10286020008039908","article-title":"A new stilbene dimer\u2014Shegansu B from Belamcanda chinensis","volume":"2","author":"Zhou","year":"2000","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/10286029808039845","article-title":"Shegansu C, a Novel Phenylpropanoid Ester of Sucrose from Belamcanda chinensis","volume":"1","author":"Lin","year":"1998","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ha, M.T., Gal, M., Kim, J.A., Lee, J.H., and Min, B.S. (2024). Sucrosephenylpropanoid esters and isoflavonoids isolated from Belamcanda chinensis roots and their potential anti-osteoclastogenic activity. Bioorg. Chem., 143.","DOI":"10.1016\/j.bioorg.2023.107066"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0031-9422(94)00677-L","article-title":"Belamcandones A-D, dioxotetrahydrodibenzofurans from Belamcanda chinensis","volume":"38","author":"Seki","year":"1995","journal-title":"Phytochemistry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2016.03.046","article-title":"Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review","volume":"186","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.fshw.2022.04.002","article-title":"Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health","volume":"11","author":"Cheng","year":"2022","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.lfs.2005.09.041","article-title":"Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells","volume":"78","author":"Ahn","year":"2006","journal-title":"Life Sci."},{"key":"ref_81","first-page":"1943","article-title":"Preparation of iristectorin A and iristectorin B and their anti-inflammatory mechanism in vitro","volume":"33","author":"Guo","year":"2024","journal-title":"Chin. J. New Drugs"},{"key":"ref_82","first-page":"3167","article-title":"Active Ingredient Irigenin from Belamcanda chinensis (L.) DC Alleviates IL-18-Mediated Pyroptosis of Corneal Epithelial Cells in Dry Eye Disease","volume":"38","author":"Yuan","year":"2024","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10787-017-0337-0","article-title":"The impact of mangiferin from Belamcanda chinensis on experimental colitis in rats","volume":"26","author":"Szandruk","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref_84","first-page":"118","article-title":"Study on Mechanism of Belamcanda Chinensis Based on Traditional Chinese Medicine Theory and Clinical Verification","volume":"20","author":"Wang","year":"2018","journal-title":"World Sci. Technol. Mod. Tradit. Chin. Med. Mater. Med."},{"key":"ref_85","first-page":"723","article-title":"Study on antinociceptive and anti-inflammatory activities and mechanism of ethanol extract of Belamcanda chinensis (L.) Redout\u00e9","volume":"44","author":"Yang","year":"2021","journal-title":"J. Zunyi Med. Univ."},{"key":"ref_86","unstructured":"Feng, J.J. (2024). Study on the Effect and Mechanism of Belamcanda chinensis Extract on Polycystic Ovary Syndrome in Mice. [Master\u2019s Thesis, Changchun University of Technology]."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1464-410X.2007.06924.x","article-title":"Phytoestrogens from Belamcanda chinensis regulate the expression of steroid receptors and related cofactors in LNCaP prostate cancer cells","volume":"100","author":"Thelen","year":"2007","journal-title":"BJU Int."},{"key":"ref_88","first-page":"116","article-title":"The Effect and Mechanism of Shegan Extract on Inflammation-related Colorectal Cancer in AOM\/DSS Mice","volume":"36","author":"Chen","year":"2022","journal-title":"J. Pract. Tradit. Chin. Intern. Med."},{"key":"ref_89","first-page":"29","article-title":"Effects of She gan Extract on MAPK And PI3K in AOM\/DSS Mouse Model of Inflammatory Associated Colorectal Cancer","volume":"37","author":"Ge","year":"2023","journal-title":"J. Pract. Tradit. Chin. Intern. Med."},{"key":"ref_90","first-page":"108","article-title":"Effect of Tectoridin on migration of lung adenocarcinoma cells and the mechanism","volume":"41","author":"Huang","year":"2022","journal-title":"Acta Acad. Med. Wannan"},{"key":"ref_91","first-page":"57","article-title":"Research on the Inhibition of Malignant Behavior of Lung Cancer Cells of Rhizoma Belamcandae Extract","volume":"33","author":"Wang","year":"2018","journal-title":"Forum Tradit. Chin. Med."},{"key":"ref_92","unstructured":"Liu, X.Y., Wang, Z.Q., Yao, N.N., Han, L., and Lu, Y.C. (2025, November 29). Tectoridin induces apoptosis and autophagy in gastric cancer cells through the PI3K\/Akt\/mTOR signaling pathway Zhonghua Zhongyiyao Xuekan 2025, 1\u201315. Available online: https:\/\/link.cnki.net\/urlid\/21.1546.R.20250312.1452.010."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/CAD.0000000000000362","article-title":"Tectorigenin inhibits osteosarcoma cell migration through downregulation of matrix metalloproteinases in vitro","volume":"27","author":"Guo","year":"2016","journal-title":"Anticancer Drugs"},{"key":"ref_94","unstructured":"Lu, Y.T. (2024). Extraction and Purification of Triterpenoids from Belamcanda chinensis and Their Effects on Obesity Model Mice. [Master\u2019s Thesis, Jiamusi University]."},{"key":"ref_95","unstructured":"Zhou, M. (2023). Proteomic Study of Protective Effects of Iristectorin B in a Cellular. [Master\u2019s Thesis, Changchun Normal University]."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"155237","DOI":"10.1016\/j.phymed.2023.155237","article-title":"Ethanol extract of Verbena officinalis alleviates MCAO-induced ischaemic stroke by inhibiting IL17A pathway-regulated neuroinflammation","volume":"123","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.biopha.2018.01.067","article-title":"Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR\/Ulk1 pathway","volume":"99","author":"Jiang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/ptr.6599","article-title":"Tectorigenin, an isoflavone aglycone from the rhizome of Belamcanda chinensis, induces neuronal expression of erythropoietin via accumulation of hypoxia-inducible factor-1\u03b1","volume":"34","author":"Liu","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/ptr.6926","article-title":"Protective effects of irigenin against 1-methyl-4-phenylpyridinium-induced neurotoxicity through regulating the Keap1\/Nrf2 pathway","volume":"35","author":"Guo","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jchromb.2010.12.022","article-title":"Combination of HPLC chromatogram and hypoglycemic effect identifies isoflavones as the principal active fraction of Belamcanda chinensis leaf extract in diabetes treatment","volume":"879","author":"Chen","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/BF02976631","article-title":"Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues","volume":"25","author":"Jung","year":"2002","journal-title":"Arch. Pharm. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s10529-012-1036-y","article-title":"Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells","volume":"34","author":"Jun","year":"2012","journal-title":"Biotechnol. Lett."},{"key":"ref_103","first-page":"1","article-title":"Study of Nano-components in Shegan (Belamcandae Rhizoma) Carbonisatum and Thier Hepatoprotective Effect","volume":"28","author":"Li","year":"2022","journal-title":"Guid. J. Tradit. Chin. Med. Pharm."},{"key":"ref_104","first-page":"147","article-title":"Bacteriostatic Effects of Belamcanda chinensis Extract in vitro and in vivo","volume":"17","author":"Qin","year":"2011","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e23225","DOI":"10.1016\/j.heliyon.2023.e23225","article-title":"Irisflorentin promotes bacterial phagocytosis and inhibits inflammatory responses in macrophages during bacterial infection","volume":"10","author":"Xiang","year":"2024","journal-title":"Heliyon"},{"key":"ref_106","first-page":"1","article-title":"Screening of in vitro antioxidant, cytotoxic and antimicrobial activities of Belamcanda chinensis aerial part","volume":"10","author":"Jahan","year":"2021","journal-title":"World J. Pharm. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jff.2018.04.048","article-title":"Effect of long-term administration of mangiferin from Belamcanda chinensis on bone metabolism in ovariectomized rats","volume":"46","author":"Nowak","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"176956","DOI":"10.1016\/j.ejphar.2024.176956","article-title":"Irilin D suppresses RANKL-induced osteoclastogenesis and prevents inflammation-induced bone loss by disrupting the NF-\u03baB and MAPK signaling pathways","volume":"982","author":"Gal","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3727\/096368915X687002","article-title":"Irisflorentin modifies properties of mouse bone marrow-derived dendritic cells and reduces the allergic contact hypersensitivity responses","volume":"24","author":"Fu","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Yuen, G.K., Ho, B.S., Lin, L.S., Dong, T.T., and Tsim, K.W. (2022). Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture. Molecules, 27.","DOI":"10.3390\/molecules27020400"},{"key":"ref_111","unstructured":"Wu, Y.J. (2023). Studies on the Chemical Constituents and Anti-Inflammatory Activities of the Ethanol Extracts of Belamcandae Rhizome and Iris Rhizome In Vitro. [Master\u2019s Thesis, Hebei University of Chinese Medicine]."},{"key":"ref_112","first-page":"82","article-title":"Optimization of total triterpene extraction process from different parts of Belamcanda chinensis and analysis of its antioxidant activity","volume":"47","author":"Gong","year":"2024","journal-title":"Feed Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mrgentox.2010.01.004","article-title":"Antimutagenic and anti-oxidant activities of isoflavonoids from Belamcanda chinensis (L.) DC","volume":"696","author":"Wozniak","year":"2010","journal-title":"Mutat. Res."},{"key":"ref_114","unstructured":"Dong, Y. (2005). Antiviral Chemical Constituents from Belamcanda chinensis Rhizomes. [Master\u2019s Thesis, Shenyang Pharmaceutical University]."},{"key":"ref_115","unstructured":"Liu, S., and Lei, X. (1985). Leigong Paozhi Lun, Jiangsu Science and Technology Press. [Critical Edition ed.]."},{"key":"ref_116","first-page":"8","article-title":"Effect of Belamcanda Chinensis and Processed Products on Serum Biochemical Indexes in Rats","volume":"20","author":"Zou","year":"2018","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"key":"ref_117","first-page":"597","article-title":"Comparative study on raw Belamcanda and processed rice swill based on the theory of \u201cinvigorating spleen and reducing dryness\u201d","volume":"33","author":"Zuo","year":"2022","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"ref_118","unstructured":"Li, C.J. (2005). A Case Report of Generalized Muscle Rigidity Caused by Belamcanda Chinensis Poisoning. J. New Med., 55, Cnki:Sun:Xyxx.0.2005-10-039."},{"key":"ref_119","first-page":"257","article-title":"Modified Gancao Jiegeng Shegan Decoction for Acute Simple Pharyngitis with Excessive Heat Syndrome of Lung and Stomach","volume":"30","author":"Huang","year":"2021","journal-title":"J. Emerg. Tradit. Chin. Med."},{"key":"ref_120","first-page":"1480","article-title":"Clinical Observation and Study on the Treatment of Acute Simple Pharyngitis with Gancao Jiegeng Shegan Decoction","volume":"40","author":"Huang","year":"2020","journal-title":"Jilin J. Tradit. Chin. Med."},{"key":"ref_121","first-page":"1092","article-title":"A Network Meta-analysis of the Efficacy of Nine Commonly Used Classical Prescriptions in Treating Bronchial Asthma in Adults","volume":"19","author":"Zhang","year":"2024","journal-title":"World Chin. Med."},{"key":"ref_122","first-page":"1292","article-title":"Pharmacophenomics characteristics and mechanisms of traditional Chinese medicine under different symptomatic phenotypes of asthma airway remodeling based on \u201cphenotype-syndrome-traditional Chinese medicine\u201d association network","volume":"56","author":"Wang","year":"2025","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_123","first-page":"682","article-title":"Preliminary Study on the Pseudoallergic Reaction of Shegan Kangbingdu Injection","volume":"11","author":"Zhang","year":"2016","journal-title":"World Chin. Med."},{"key":"ref_124","first-page":"254","article-title":"Expert Consensus on Clinical Application of Shema Oral Liquid in Treatment of Chronic Obstructive Pulmonary Disease","volume":"41","author":"Feng","year":"2023","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"ref_125","unstructured":"Zhang, Z.T., and He, L.H. (2012). Tea for Preventing and Treating Elderly Constipation and Preparation Method Thereof. (102422938 A), CN Patent."},{"key":"ref_126","unstructured":"Huang, R., Zhang, H., and Jia, Y. (2015). A Halitosis Removing Health-Care Tea Bag and a Preparation Method Thereof. (104904940 A), CN Patent."},{"key":"ref_127","unstructured":"Huh Mun, Y., Kim Hyeon, P.Y.O., Kim Jeong, H.A., and Lee Gang, T.A.E. (2006). Cosmetic Compositions Containing Belamcanda Extracts. (20010092068 A), KR Patent."},{"key":"ref_128","unstructured":"Lee Hoon, K.O.O., Seo Dong, S.O.O., and Sok Chang, H. (2015). Hair and Scalp Protective Composition for Hair Dyeing. (20130092921 A), KR Patent."},{"key":"ref_129","unstructured":"Yang, D., and Yang, X. (2015). Natural Bactericide for Prevention and Treatment of Peach Brown Rot and Preparation Method Thereof. (103340218 A), CN Patent."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/14\/23\/3688\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T05:20:06Z","timestamp":1764912006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/14\/23\/3688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":129,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["plants14233688"],"URL":"https:\/\/doi.org\/10.3390\/plants14233688","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}