{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:43:38Z","timestamp":1785437018275,"version":"3.56.0"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373978"],"award-info":[{"award-number":["82373978"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82373978"],"award-info":[{"award-number":["82373978"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231307"],"award-info":[{"award-number":["BK20231307"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province"},{"name":"Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine","award":["ZYXYL2024-002"],"award-info":[{"award-number":["ZYXYL2024-002"]}]},{"name":"Nanjing University of Chinese Medicine Cultivation Project","award":["RC202503"],"award-info":[{"award-number":["RC202503"]}]},{"name":"Innovation Projects of State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture","award":["NZYSKL240208"],"award-info":[{"award-number":["NZYSKL240208"]}]},{"name":"Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Program","award":["MS 2022005"],"award-info":[{"award-number":["MS 2022005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Salt stress affects the growth, quality, and secondary metabolism of medicinal plants, but its effects on essential oil biosynthesis in Schizonepeta tenuifolia remain unclear. In this study, a salt stress model was established for Schizonepeta tenuifolia (Benth.) Briq. to investigate changes in growth, monoterpenoid accumulation, non-targeted metabolism, and transcriptional profiles. To further clarify the regulatory mechanism of monoterpenoids biosynthesis, the MYB family members were identified at the genome-wide level, and candidate regulators were screened based on the expression patterns and promoter features of StL3OH (limonene -3-hydroxylase). Among them, StMYB71 and StMYB8774 were identified as candidate regulators of monoterpene biosynthesis. Functional analysis indicated that both transcription factors negatively regulated StL3OH expression by binding to the MYBHv1 cis-element in its promoter. These findings improve our understanding of the salt stress response and transcriptional regulation of monoterpene biosynthesis in S. tenuifolia and provide a basis for the future improvement of Schizonepetae Herba quality and salt tolerance.<\/jats:p>","DOI":"10.3390\/plants15101469","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:49:09Z","timestamp":1778572149000},"page":"1469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MYB Transcription Factors Negatively Regulate StL3OH in Salt Stress Response of Schizonepeta tenuifolia"],"prefix":"10.3390","volume":"15","author":[{"given":"Jingjie","family":"Dang","sequence":"first","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoqi","family":"Pan","sequence":"additional","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-1091","authenticated-orcid":false,"given":"Mengru","family":"Sang","sequence":"additional","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-0315","authenticated-orcid":false,"given":"Dishuai","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiu","family":"Shan","sequence":"additional","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchan","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinan","family":"Wu","sequence":"additional","affiliation":[{"name":"National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/0091270002042001003","article-title":"Schizonepeta tenuifolia: Chemistry, pharmacology, and clinical applications","volume":"42","author":"Fung","year":"2002","journal-title":"J. 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