{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:20:36Z","timestamp":1778682036623,"version":"3.51.4"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science","award":["PID2020\u2013119734RB-I00"],"award-info":[{"award-number":["PID2020\u2013119734RB-I00"]}]},{"name":"EU CBE JU","award":["101209410"],"award-info":[{"award-number":["101209410"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The Mediterranean Sea harbors a rich diversity of macroalgae with pharmacological potential. In this study, antioxidant and antifungal activities of methanol and ethyl acetate extracts from Rugulopteryx okamurae, Dictyota fasciola, Batophora sp., Codium fragile, and Palisada tenerrima from the southeastern coast of Spain were evaluated. R. okamurae, Batophora sp. and C. fragile are non-native. All extracts exhibited antioxidant activity, particularly those obtained with methanol. R. okamurae and Batophora sp. showed the highest activity, inhibiting the DPPH\u00b7 radical by more than 40% at 1 mg\/mL. Methanolic extracts of R. okamurae and P. tenerrima showed in vitro fungistatic activity against the banana plant pathogenic fungus Fusarium oxysporum f. sp. cubense tropical race 4. R. okamurae exhibited the highest antifungal activity, with inhibition values of 23.3% and 30.5% at 10 and 20 mg\/well, respectively, while P. tenerrima showed moderate activity, and the remaining extracts had lower effects. LC\u2013MS\/MS analysis of R. okamurae revealed a diverse metabolite profile, including oxylipin-type metabolites and terpenoid-related compounds. These results indicate that macroalgae from the southeastern Spanish coast may represent a source of antioxidant and antifungal compounds and support the valorization of invasive biomass.<\/jats:p>","DOI":"10.3390\/plants15101485","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:46:55Z","timestamp":1778676415000},"page":"1485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening Antifungal and Antioxidant Activity of Macroalgae from SE Spain Highlights the Invader Rugulopteryx okamurae"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-5258","authenticated-orcid":false,"given":"Miguel","family":"Valverde-Urrea","sequence":"first","affiliation":[{"name":"Plant Pathology Laboratory, Department of Marine Sciences and Applied Biology, Universidad of Alicante, Aptdo. Correos 99, 03080 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Kaylly","family":"Otero","sequence":"additional","affiliation":[{"name":"Plant Pathology Laboratory, Department of Marine Sciences and Applied Biology, Universidad of Alicante, Aptdo. Correos 99, 03080 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Terradas-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Plant Pathology Laboratory, Department of Marine Sciences and Applied Biology, Universidad of Alicante, Aptdo. Correos 99, 03080 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-0702","authenticated-orcid":false,"given":"Federico","family":"Lopez-Moya","sequence":"additional","affiliation":[{"name":"Plant Pathology Laboratory, Department of Marine Sciences and Applied Biology, Universidad of Alicante, Aptdo. Correos 99, 03080 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"Las algas marinas como fuentes de fitof\u00e1rmacos antioxidantes","volume":"14","author":"Batista","year":"2009","journal-title":"Rev. Cuba. Plantas Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbagen.2009.03.011","article-title":"Marine pharmacology in 2005\u20132006: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action","volume":"1790","author":"Mayer","year":"2009","journal-title":"Biochim. Biophys. 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