{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:38:51Z","timestamp":1792046331212,"version":"4.4.0"},"reference-count":76,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South Africa National Department of Agriculture"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Cancer represents one of the major public health issues in sub-Saharan Africa (SSA), with increasing incidence and mortality rates as a result of late diagnosis, limited healthcare infrastructure, and financial difficulties. Traditional medicine plays an important role in healthcare across different populations in SSA, as more than 80% of the population depend on indigenous plant-based remedies for treating or managing different ailments, including cancer. This study aimed to document medicinal plants traditionally used to treat cancer in SSA. A systematic search of all documents available in the last two decades (2006\u20132026) was conducted using PubMed, Web of Science, and Google Scholar databases. After screening studies using the predefined inclusion and exclusion criteria, 55 studies met the eligibility requirements and were selected for analysis based on their relevance to the topic, geographic scope, and reported applications in cancer management. The scientific names of the identified plant species and their taxonomic authorities were verified using the Plants of the World Online database. A total of 556 species, belonging to 110 families, were recorded as medicinal plants used to treat various forms of cancer in SSA. The top five families with the most frequently used plants were Fabaceae (51 species), Asteraceae (34 species), Euphorbiaceae (25 species), Apocynaceae (22 species) and Lamiaceae (22 species). Frequently cited plants include Kigelia africana, Annona muricata, Adansonia digitata, Carica papaya, and Tamarindus indica. A total of 11 plant parts were documented, with leaves (41.20%), roots (18.75%), and bark (17.25%) being the dominant plant parts utilised. The primary methods of preparation were decoction (38.23%), powdering and grinding (14.51%), and infusion and tea preparation (49.73%), while the main modes of administration were oral (66.88%) and topical (26.46%). The results show that traditional medicinal plants hold significant potential as sources of novel anticancer drugs in SSA. However, a significant gap exists between ethnobotanical knowledge, laboratory research, and clinical application. Rigorous pharmacological and toxicity evaluations and well-designed clinical trials on the identified medicinal plants are needed to integrate effective and safe plant-based therapies into evidence-based oncology.<\/jats:p>","DOI":"10.3390\/plants15121836","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:44:58Z","timestamp":1781484298000},"page":"1836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Traditional Medicinal Plants Used for Cancer Treatment in Sub-Saharan Africa: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-0040","authenticated-orcid":false,"given":"Tomi Lois","family":"Adetunji","sequence":"first","affiliation":[{"name":"Agricultural Research Council\u2014Vegetables, Industrial and Medicinal Plants, Private Bag X293, Roodeplaat, Pretoria 0001, South Africa"},{"name":"Unit for Environmental Sciences and Management, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-673X","authenticated-orcid":false,"given":"Funsho","family":"Oyetunde-Joshua","sequence":"additional","affiliation":[{"name":"Faculty of Natural and Environmental Sciences, Philomath University, Kuje 900105, Abuja, Federal Capital Territory, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-5958","authenticated-orcid":false,"given":"Olalekan Bukunmi","family":"Ogunro","sequence":"additional","affiliation":[{"name":"Drug Discovery, Pharmacology and Toxicology Research Laboratory (DDPT-RL), Department of Biological Sciences, KolaDaisi University, Ibadan 200213, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olumayowa","family":"Andrew","sequence":"additional","affiliation":[{"name":"Centre for Soil, Agrifood and Biosciences, Cranfield University, College Road, Bedfordshire MK43 0AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-5436","authenticated-orcid":false,"given":"Stephen O.","family":"Amoo","sequence":"additional","affiliation":[{"name":"Agricultural Research Council\u2014Vegetables, Industrial and Medicinal Plants, Private Bag X293, Roodeplaat, Pretoria 0001, South Africa"},{"name":"Unit for Environmental Sciences and Management, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gaobotse, G., Venkataraman, S., Brown, P.D., Masisi, K., Kwape, T.E., Nkwe, D.O., Rantong, G., and Makhzoum, A. 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