{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:47:10Z","timestamp":1782398830963,"version":"3.54.5"},"reference-count":62,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS Core-to-Core Program","doi-asserted-by":"publisher","award":["JPJSCCB20230005"],"award-info":[{"award-number":["JPJSCCB20230005"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This study investigates the phytochemical and pharmacological profiles of Crinum asiaticum L. var. anomalum Baker from Vietnam. Phytochemical screening identified diverse secondary metabolites, including polyphenols, flavonoids, and alkaloids. Gas chromatography\u2013mass spectrometry analysis of the n-hexane fractions revealed 19 major compounds. While all extracts showed moderate antioxidant activity, the chloroform fraction exhibited superior antidiabetic potential via \u03b1-amylase inhibition (IC50 = 83.13 \u00b1 6.67 \u00b5g\/mL). Furthermore, at non-cytotoxic concentrations (3.13 to 50 \u00b5g\/mL), this fraction effectively rescued mouse \u03b2-TC6 insulinoma cells from thapsigargin. In anti-inflammatory assays, the n-hexane fraction significantly suppressed nitric oxide production in RAW 264.7 macrophages (IC50 = 53.12 \u00b1 1.63 \u00b5g\/mL). Notably, the extracts displayed remarkable selective anticancer activity, particularly the chloroform fraction against HeLa cervical and HepG2\/Huh-7 hepatoma cell lines. In silico ADMET and Lipinski\u2019s Rule of Five analyses confirmed that the key bioactive constituents possess favorable pharmacokinetic profiles and drug-likeness. These findings demonstrate C. asiaticum L. var. anomalum Baker as a promising natural source for developing multitarget therapeutic agents against inflammation, diabetes, and cancer.<\/jats:p>","DOI":"10.3390\/plants15131957","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:37:55Z","timestamp":1782391075000},"page":"1957","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Profiling and Multitargeted Biological Activities of Crinum asiaticum L. var. anomalum Baker Leaf: In Vitro and In Silico Insights"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-9412","authenticated-orcid":false,"given":"Tue Minh","family":"Duong","sequence":"first","affiliation":[{"name":"Department Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-6669","authenticated-orcid":false,"given":"Son Hoang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, Japan"},{"name":"Faculty of Biochemistry and Food Technology, Vinh Long University of Technology Education, Vinh Long 85000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiep Minh","family":"Do","sequence":"additional","affiliation":[{"name":"Faculty of Biochemistry and Food Technology, Vinh Long University of Technology Education, Vinh Long 85000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-7827","authenticated-orcid":false,"given":"Tran Thanh","family":"Men","sequence":"additional","affiliation":[{"name":"Faculty of Biology, College of Natural Science, Can Tho University, Can Tho 94000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-9613","authenticated-orcid":false,"given":"Kenji","family":"Kanaori","sequence":"additional","affiliation":[{"name":"Department Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-4692","authenticated-orcid":false,"given":"Kaeko","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Soto-V\u00e1squez, M.R., Rodr\u00edguez-Mu\u00f1oz, C.A., Tallini, L.R., and Bastida, J. 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