{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:58:09Z","timestamp":1791043089801,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The present ethnopharmacological study investigated the traditional medicinal uses of Alchemilla species distributed across different geobotanical regions of Azerbaijan. Field surveys were conducted in five mountainous regions of the country during 2024\u20132025, and ethnopharmacological data were collected from 125 informants through semi-structured interviews and questionnaire surveys. A total of 21 Alchemilla species belonging to the Rosaceae family were documented. Quantitative ethnobotanical indices, including Use Value (UV), Relative Frequency of Citation (RFC), Fidelity Level (FL), and Informant Consensus Factor (ICF), were applied to evaluate the ethnobotanical significance of the recorded species. The results revealed that Alchemilla species are mainly used for the treatment of digestive, hepatobiliary, respiratory, and skin disorders, as well as for the management of diabetes. The highest ICF value was recorded for antipyretic use (ICF = 1.00), whereas the greatest number of use reports was documented for digestive system disorders (Nur = 278). Alchemilla sericea, A. sericata, A. caucasica and A. grossheimii exhibited the highest UV and RFC values. The high quantitative ethnobotanical indices reflect the relative local importance of these species and the strong consensus among informants regarding their traditional medicinal uses. The findings demonstrate the important role of Alchemilla species in the traditional medicine of Azerbaijan and indicate that species with high ethnobotanical indices represent promising candidates for future phytochemical and pharmacological investigations.<\/jats:p>","DOI":"10.3390\/plants15142241","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:01:28Z","timestamp":1784768488000},"page":"2241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Traditional Medicinal Uses and Ethnopharmacological Significance of Alchemilla L. Species in Azerbaijan"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-4559","authenticated-orcid":false,"given":"Javanshir","family":"Isayev","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvin","family":"Nagiyev","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0534-4003","authenticated-orcid":false,"given":"Gunay","family":"Jafarova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufar","family":"Safarova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagida","family":"Mammadova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","unstructured":"Karyagin, I.I. (1954). Flora Azerbajana, Academy of Sciences of the Azerbaijan SSR."},{"key":"ref_2","unstructured":"Grossheim, A.A. (1952). Flora Kavkaza, Academy of Sciences of the USSR."},{"key":"ref_3","first-page":"48","article-title":"Studying of Pharmacological Characteristics and Medical Use of Some Plants in the Flora of Azerbaijan","volume":"2","author":"Isayev","year":"2006","journal-title":"Azerbaijan Med. J."},{"key":"ref_4","first-page":"46","article-title":"Ethnopharmacological Study of Plants Used in Diabar Region, Azerbaijan","volume":"34","author":"Isayev","year":"2026","journal-title":"Ethnobot. Res. Appl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.34921\/amj.2025.4.019","article-title":"Ethnopharmacological Studies of the Treatment of Urological Diseases in the Territory of the Gadabay Region of the Republic of Azerbaijan","volume":"4","author":"Isayev","year":"2025","journal-title":"Azerbaijan Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.34921\/amj.2025.1.030","article-title":"Ethnopharmacological study of the treatment of cardiovascular diseases in the Guba mountain geobotanical region of Azerbaijan","volume":"1","author":"Isayev","year":"2025","journal-title":"Azerbaijan Med. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.34921\/amj.2024.4.024","article-title":"Ethnopharmacological Study of the Treatment of Diseases of the Digestive System in the Geobotanical Region of Azerbaijan Nakhichevan Highlands","volume":"4","author":"Isayev","year":"2024","journal-title":"Azerbaijan Med. J."},{"key":"ref_8","first-page":"121","article-title":"Ethnopharmacological Study of the Treatment of Diseases of the Respiratory System in the Zuvand Geobotanical Territory of Azerbaijan","volume":"3","author":"Isayev","year":"2024","journal-title":"Azerbaijan Med. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"270309","DOI":"10.13057\/biodiv\/d270309","article-title":"Quantitative Ethnobotanical Assessment of Medicinal Plants in Zagatala District, Azerbaijan","volume":"27","author":"Isayev","year":"2026","journal-title":"Biodiversitas J. Biol. Divers."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kanak, S., Krzemi\u0144ska, B., Celi\u0144ski, R., Bakalczuk, M., and Dos Santos Szewczyk, K. (2022). Phenolic Composition and Antioxidant Activity of Alchemilla Species. Plants, 11.","DOI":"10.3390\/plants11202709"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Suru\u010di\u0107, R., Radovi\u0107 Selgrad, J., Kundakovi\u0107-Vasovi\u0107, T., Lazovi\u0107, B., Travar, M., Suru\u010di\u0107, L., and \u0160krbi\u0107, R. (2022). In Silico and In Vitro Studies of Alchemilla viridiflora Rothm\u2014Polyphenols\u2019 Potential for Inhibition of SARS-CoV-2 Internalization. Molecules, 27.","DOI":"10.3390\/molecules27165174"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e202500539","DOI":"10.1002\/cbdv.202500539","article-title":"Biological and Phytochemical Investigations of Alchemilla daghestanica Juz. and Alchemilla minusculiflora Buser: A Focus on Anti-Inflammatory and Skin-Regenerative Properties","volume":"22","author":"Ortahisar","year":"2025","journal-title":"Chem. Biodivers."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.15832\/ankutbd.1631483","article-title":"Phytochemical Composition, Antioxidant and Metabolic Enzyme Activity of Alchemilla vulgaris Grown in Organic Farming Conditions","volume":"32","author":"Pekacar","year":"2026","journal-title":"J. Agric. Sci.-Tarim Bil."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jela\u010da, S., Daji\u0107-Stevanovi\u0107, Z., Vukovi\u0107, N., Kola\u0161inac, S., Trendafilova, A., Nedialkov, P., Stankovi\u0107, M., Tani\u0107, N., Tani\u0107, N.T., and Acovi\u0107, A. (2022). Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro. Molecules, 27.","DOI":"10.3390\/molecules27238113"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/09735070.2013.11886446","article-title":"The Trade and Use of Some Medical and Aromatic Herbs in Turkey","volume":"7","author":"Akbulut","year":"2013","journal-title":"Stud. Ethno-Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117439","DOI":"10.1016\/j.jep.2023.117439","article-title":"A review of the traditional uses, phytochemistry, pharmacology, and clinical evidence for the use of the genus Alchemilla (Rosaceae)","volume":"320","author":"Jakimiuk","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Karpavi\u010dien\u0117, B. (2022). Traditional Uses of Medicinal Plants in South-Western Part of Lithuania. Plants, 11.","DOI":"10.3390\/plants11162093"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"120068","DOI":"10.1016\/j.jep.2025.120068","article-title":"Unveiling the Ethnomedicinal Potential of Alchemilla speciosa Buser: An Underexplored Source of Bioactive Compounds for Skin Health","volume":"351","author":"Kanak","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2015.01.008","article-title":"An Ethnobotanical Study on Medicinal Plants in Espiye and Its Surrounding (Giresun\u2013Turkey)","volume":"163","author":"Polat","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1515\/chem-2022-0204","article-title":"Ethnopharmacological Study of Medicinal Plants in Kastamonu Province (T\u00fcrkiye)","volume":"20","author":"Akbulut","year":"2022","journal-title":"Open Chem."},{"key":"ref_21","unstructured":"World Health Organization (WHO) (2026, May 18). International Classification of Diseases 11th Revision (ICD-11). Available online: https:\/\/icd.who.int\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5152\/eurasianjmed.2020.19243","article-title":"Isolation of Major Compounds and Gastroprotective Activity of Alchemilla caucasica on Indomethacin-Induced Gastric Ulcers in Rats","volume":"52","author":"Karaoglan","year":"2020","journal-title":"Eurasian J. Med."},{"key":"ref_23","unstructured":"Ministry of Ecology and Natural Resources of the Republic of Azerbaijan (2023). Red Book of the Republic of Azerbaijan: Flora."},{"key":"ref_24","unstructured":"International Society of Ethnobiology (ISE) (2025, June 10). International Society of Ethnobiology Code of Ethics (with 2008 Additions). Available online: https:\/\/www.ethnobiology.net\/code-of-ethics\/."},{"key":"ref_25","unstructured":"Plants of the World Online (POWO) (2026, May 18). Facilitated by the Royal Botanic Gardens, Kew. Available online: https:\/\/powo.science.kew.org\/."},{"key":"ref_26","first-page":"1899","article-title":"Ethnobotanical Indices Based Ethnoveterinary Plant Profile of Jabban Hills, Malakand, Hindukush Range, Pakistan","volume":"50","author":"Barkatullah","year":"2018","journal-title":"Pak. J. Bot."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.hermed.2017.10.001","article-title":"Ethnobotanical Importance of Medicinal Plants Traded in the Herbal Markets of Rawalpindi, Pakistan","volume":"11","author":"Ahmad","year":"2018","journal-title":"J. Herb. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4314\/ijbcs.v8i5.24","article-title":"Ethnoveterinary Management of Cattle Helminthiasis among the Fulani and the Mossi in Central Burkina Faso","volume":"8","author":"Hilou","year":"2014","journal-title":"Int. J. Biol. Chem. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.chnaes.2020.12.006","article-title":"Traditional Knowledge of Wild Medicinal Plants Used by the Inhabitants of Garam Chashma Valley, District Chitral, Pakistan","volume":"42","author":"Birjees","year":"2022","journal-title":"Acta Ecol. Sin."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0378-8741(86)90094-2","article-title":"A Preliminary Classification of the Healing Potential of Medicinal Plants Based on an Ethnopharmacological Field Survey among Bedouins in the Negev Desert","volume":"16","author":"Friedman","year":"1986","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Umair, M., Altaf, M., and Abbasi, A.M. (2017). An Ethnobotanical Survey of Indigenous Medicinal Plants in Hafizabad District, Punjab, Pakistan. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177912"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/14\/2241\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:16:37Z","timestamp":1784866597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/14\/2241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":31,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["plants15142241"],"URL":"https:\/\/doi.org\/10.3390\/plants15142241","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}