{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:58:07Z","timestamp":1785560287047,"version":"3.56.0"},"reference-count":31,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010301","name":"Faculty of Medical Sciences, University of Kragujevac","doi-asserted-by":"crossref","award":["451-03-34\/2026-03\/200111"],"award-info":[{"award-number":["451-03-34\/2026-03\/200111"]}],"id":[{"id":"10.13039\/501100010301","id-type":"DOI","asserted-by":"crossref"}]},{"award":["451-03-34\/2026-03\/200111"],"award-info":[{"award-number":["451-03-34\/2026-03\/200111"]}],"id":[{"id":"https:\/\/ror.org\/04f7vj627","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Psoriasis is a chronic immune-mediated systemic disorder that extends beyond the skin and may adversely affect cardiovascular function. Herbal therapies have emerged as promising complementary approaches for mitigating psoriasis-associated cardiac complications. The present study aimed to evaluate the cardioprotective potential of Melissa officinalis (MO) extract in psoriasis. Twenty-four male Wistar albino rats were randomly assigned to four experimental groups: control, MO, psoriasis (PSORI), and PSORI+MO. After induction, animals received MO extract (200 mg\/kg b.w.) orally for three weeks. Cardiac function was assessed using the Langendorff isolated heart preparation. Oxidative stress and inflammatory cytokines were determined in blood. Psoriatic rats exhibited impaired myocardial contractility and relaxation, accompanied by elevated SLVP and DLVP across all perfusion pressures. Administration of MO significantly improved cardiac performance and attenuated these hemodynamic disturbances. Oxidative stress markers and inflammatory cytokines were markedly reduced in the PSORI+MO group compared with PSORI. Cardiomyocyte diameter and cross-sectional area were increased in both PSORI and PSORI+MO groups relative to controls. Collagen content was substantially elevated in the PSORI group and remained increased, although to a lesser extent, in the PSORI+MO group compared with controls. These findings suggest that MO extract may represent a promising complementary strategy for reducing psoriasis-associated cardiovascular alterations.<\/jats:p>","DOI":"10.3390\/plants15152342","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:09:42Z","timestamp":1785398982000},"page":"2342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melissa officinalis Mitigates Psoriasis-Associated Cardiac Remodeling Through Antioxidant and Anti-Inflammatory Mechanisms"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-8116","authenticated-orcid":false,"given":"Nevena","family":"Lazarevic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Department of Human Pathology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Andjic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-1990","authenticated-orcid":false,"given":"Katarina","family":"Mihajlovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-6085","authenticated-orcid":false,"given":"Jovana","family":"Bradic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-436X","authenticated-orcid":false,"given":"Aleksandar","family":"Kocovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, 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Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-8376","authenticated-orcid":false,"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Department of Pathophysiology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-5752","authenticated-orcid":false,"given":"Maja","family":"Muric","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-0626","authenticated-orcid":false,"given":"Jovana","family":"Joksimovic Jovic","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Bolevich","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, 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Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176206"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5937\/jomb0-45076","article-title":"Oxidative Stress and Metabolic Biomarkers in Patients with Psoriasis","volume":"43","year":"2024","journal-title":"J. Med. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109032","DOI":"10.1016\/j.intimp.2022.109032","article-title":"The Immunoregulatory Effects of Natural Products on Psoriasis via Its Action on Th17 Cells Versus Regulatory T Cells Balance","volume":"110","author":"Zhong","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jep.2016.05.010","article-title":"Melissa officinalis L.\u2014A Review of Its Traditional Uses, Phytochemistry and Pharmacology","volume":"188","author":"Shakeri","year":"2016","journal-title":"J. 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