{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:29:18Z","timestamp":1787225358765,"version":"build-2736575974"},"reference-count":109,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Arbuscular mycorrhizal fungi (AMF) establish a reciprocal interaction with plant roots, enhancing nutrient acquisition, stress tolerance, and the production of bioactive metabolites. These symbiotic fungi represent a sustainable alternative to chemical fertilizers to improve the quality and yield of medicinal and aromatic plants such as Oregano (Origanum compactum). In this study, we investigated the effects of mycorrhizal inoculation on the chemical composition, nutritional profile, and biological activities of Oregano cultivated under greenhouse conditions. Compared with non-mycorrhizal plants, mycorrhizal-inoculated plants showed approximately 33% higher protein content and 28% higher total sugar content, while lipid concentration decreased slightly by about 7%. Mycorrhizal inoculation also promoted the accumulation of secondary metabolites, resulting in increased concentrations of total polyphenol and flavonoid contents by approximately 33% and 25%, respectively. These compositional changes were associated with markedly enhanced antioxidant capacity, exceeding that of the reference antioxidant, as well as improved antibacterial activity, characterized by larger inhibition zones and lower minimum inhibitory concentrations against tested pathogens. Overall, mycorrhizal fungal inoculation reshaped the chemical composition and the major bioactive compounds of Oregano, thereby enhancing its nutritional and antimicrobial potential. These findings highlight the potential of AMF-based cultivation strategies to improve the phytochemical quality and medicinal potential of Oregano while supporting sustainable agricultural production.<\/jats:p>","DOI":"10.3390\/plants15162518","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:55:18Z","timestamp":1787223318000},"page":"2518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mycorrhizal Fungal Inoculation Reshapes Chemotype, Nutritional Status, and Metabolic Signatures to Enhance Bioactivity in Origanum compactum Benth."],"prefix":"10.3390","volume":"15","author":[{"given":"Akhallaa","family":"Youne Oumnia","sequence":"first","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7299-2067","authenticated-orcid":false,"given":"Akhallaa Youne","family":"Mounia","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouahmane","family":"Kaoutar","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4962-8831","authenticated-orcid":false,"given":"Rhouch","family":"Said","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-905X","authenticated-orcid":false,"given":"Bouskout","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Kaddouri","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfeddy Mohamed","family":"Najib","sequence":"additional","affiliation":[{"name":"Phytobacteriology Laboratory Plant Protection Research, Unit CRRA Marrakesh National Institute for Agronomical Research Marrakesh, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-4407","authenticated-orcid":false,"given":"Mnasri","family":"Bacem","sequence":"additional","affiliation":[{"name":"Laboratory of Legumes and Sustainable Agrosystems, Centre of Biotechnology of Borj-C\u00e9dria, BP 901, Hammam-Lif 2050, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tounsi","family":"Abdessamad","sequence":"additional","affiliation":[{"name":"Environmental, Ecological and Agro-Industrial Engineering Laboratory, Faculty of Sciences and Techniques, University Sultan Moulay Slimane, Avenue Mohamed V. BP 591, Beni Mellal 23000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dounas","family":"Hanane","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Nazameen","sequence":"additional","affiliation":[{"name":"Department of Botany, Bacha Khan University, Charsadda 24420, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-3298","authenticated-orcid":false,"given":"Yaseen","family":"Khan","sequence":"additional","affiliation":[{"name":"Center for Eco-Environment Restoration Engineering of Hainan Province, School of Ecology, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-549X","authenticated-orcid":false,"given":"Ouahmane","family":"Lahcen","sequence":"additional","affiliation":[{"name":"Laboratory of Water Sciences, Microbial Biotechnologies and Natural Resources Sustainability, Unit of Microbial Biotechnologies, Agrosciences, and Environment-CNRST Labeled Research Unit N\u00b04, Faculty of Sciences Semlalia, Cadi Ayyad University, P.O. Box 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e13251","DOI":"10.1111\/jfbc.13251","article-title":"Origanum compactum Benth., from traditional use to biotechnological applications","volume":"44","author":"Bouyahya","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_2","first-page":"87","article-title":"GC-MS analysis and in vitro study of antifungal, antiurease and anticholinesterase potentials of Origanum compactum Benth. essential oil","volume":"9","author":"Debbi","year":"2022","journal-title":"NVEO\u2014Nat. Volatiles Essent. 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