{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:16:16Z","timestamp":1788066976394,"version":"build-2784847793"},"reference-count":165,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"FUNDECT\/MS","doi-asserted-by":"publisher","award":["83\/043.831\/2025"],"award-info":[{"award-number":["83\/043.831\/2025"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Pantanal is the largest wetland on the American continent. This biome contains several plant species of interest for the development of medicines and cosmetics. Hence, this work aimed to review technologies described in patents concerning highly published plants from the Pantanal and their pharmacological and cosmetic applications. This research surveyed species in the Brazilian Pantanal and identified those with relevant scientific data. Patent searches for the selected species were conducted covering the past 10 years. Overall, 1859 plant and fungal species from the Pantanal were identified. Anacardium occidentale L., Annona montana Macfad., Annona muricata L., Annona squamosa L., and Calotropis procera (Aiton) W.T. Aiton presented the highest number of scientific publications. The patent search yielded 58 patents, mostly filed by private companies and in South Korea. Additionally, extracts were the primary products examined. The main pharmacological activities exploited were antitumoral, anti-inflammatory, and antidiabetic. For cosmetic compositions, the main activities were anti-aging, anti-acne, hair loss, and skin whitening. Despite strong scientific evidence for the included plant species, their claimed activities, and filings from Countries with a strong history of technology development, most studies focused on extracts. Therefore, the development of formulations to deliver these plant extracts is encouraged to improve technology transfer.<\/jats:p>","DOI":"10.3390\/plants15172632","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:33:52Z","timestamp":1787942032000},"page":"2632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovation and Biodiversity: Patent Trends in Therapeutic and Cosmetic Use of Scientifically Relevant Pantanal Plants"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-1968","authenticated-orcid":false,"given":"Danielle Teixeira","family":"Freire","sequence":"first","affiliation":[{"name":"Laboratory of Micro and Nanostructured Systems, College of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-5217","authenticated-orcid":false,"given":"Douglas","family":"Dourado","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalisson Amorim de","family":"Souza","sequence":"additional","affiliation":[{"name":"Cibles Th\u00e9rapeutiques et Conception de M\u00e9dicaments (CiTCoM), Unit\u00e9 Mixte de Recherche (UMR) 8038, Centre National de la Recherche Scientifique CNRS, Facult\u00e9 de Pharmacie de Paris, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-6804","authenticated-orcid":false,"given":"\u00c9verton do Nascimento","family":"Alencar","sequence":"additional","affiliation":[{"name":"Laboratory of Micro and Nanostructured Systems, College of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","first-page":"1703","article-title":"Delimita\u00e7\u00e3o do Pantanal brasileiro e suas sub-regi\u00f5es","volume":"33","author":"Silva","year":"1998","journal-title":"Pesqui. Agropecu. Bras."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ellwanger, J.H., Nobre, C.A., and Chies, J.A.B. (2023). Brazilian Biodiversity as a Source of Power and Sustainable Development: A Neglected Opportunity. Sustainability, 15.","DOI":"10.3390\/su15010482"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-Derived Natural Products: A Source for Drug Discovery and Development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: A review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Naeem, A., Hu, P., Yang, M., Zhang, J., Liu, Y., Zhu, W., and Zheng, Q. (2022). Natural Products as Anticancer Agents: Current Status and Future Perspectives. Molecules, 27.","DOI":"10.3390\/molecules27238367"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bouzroud, S., El Maaiden, E., Sobeh, M., Merghoub, N., Boukcim, H., Kouisni, L., and El Kharrassi, Y. (2023). Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021397"},{"key":"ref_7","unstructured":"Presid\u00eancia da Rep\u00fablica (2015). Disp\u00f5e sobre o Acesso ao Patrim\u00f4nio Gen\u00e9tico, Sobre a Prote\u00e7\u00e3o e o Acesso ao Conhecimento Tradicional Associado e sobre a Reparti\u00e7\u00e3o de Benef\u00edcios para Conserva\u00e7\u00e3o e uso Sustent\u00e1vel da Biodiversidade (Standard No. Lei n\u00ba 13.123, de 20 de maio de 2015)."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40552-015-0007-y","article-title":"The scientific information provided through patents and its limited use in scientific research at universities","volume":"2","author":"Pereira","year":"2015","journal-title":"Braz. J. Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mejia, C., and Kajikawa, Y. (2025). Patent research in academic literature. Landscape and trends with a focus on patent analytics. Front. Res. Metr. Anal., 9.","DOI":"10.3389\/frma.2024.1484685"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Barbosa, W., Correia, P., Vieira, J., Leal, I., Rodrigues, L., Nery, T., Barbosa, J., and Soares, M. (2023). Trends and Technological Challenges of 3D Bioprinting in Cultured Meat: Technological Prospection. Appl. Sci., 13.","DOI":"10.3390\/app132212158"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/1751-7915.14201","article-title":"Patent landscape analysis\u2014Contributing to the identification of technology trends and informing research and innovation funding policy","volume":"16","author":"Timmis","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_12","unstructured":"Brasil (2025, September 01). Flora e Funga do Brasil. Jardim Bot\u00e2nico do Rio de Janeiro, Available online: https:\/\/floradobrasil.jbrj.gov.br\/consulta\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"119509","DOI":"10.1016\/j.biopha.2026.119509","article-title":"Unraveling approaches for cannabidiol delivery nanosystems: A patent review","volume":"199","author":"Freire","year":"2026","journal-title":"Biomed. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100441","DOI":"10.1016\/j.prmcm.2024.100441","article-title":"An overview on the phytochemical and therapeutic potential of Calotropis procera","volume":"11","author":"Singh","year":"2024","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/09692290.2020.1824930","article-title":"The made in China challenge to US structural power: Industrial policy, intellectual property and multinational corporations","volume":"29","author":"Malkin","year":"2022","journal-title":"Rev. Int. Political Econ."},{"key":"ref_17","unstructured":"Ministry of Health and Welfare (2025, October 06). K-Bio Pharmaceutical Industry to Accelerate Innovation to Become a Global Top Five Power, Available online: https:\/\/www.mohw.go.kr\/board.es?mid=a20401000000&bid=0032&act=view&list_no=1487395&tag=&nPage=1."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121420","DOI":"10.1016\/j.techfore.2021.121420","article-title":"Motives to Publish, to Patent and to Standardize: An Explorative Study Based on Individual Engineers\u2019 Assessments","volume":"175","author":"Blind","year":"2022","journal-title":"Technol. Forecast. Soc. Change"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s11101-024-09928-w","article-title":"Advanced high-resolution chromatographic strategies for efficient isolation of natural products from complex biological matrices: From metabolite profiling to pure chemical entities","volume":"23","author":"Queiroz","year":"2024","journal-title":"Phytochem. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1039\/C9NP00004F","article-title":"Innovative omics-based approaches for prioritisation and targeted isolation of natural products\u2014New strategies for drug discovery","volume":"36","author":"Wolfender","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_21","first-page":"113","article-title":"Acetogenins from annonaceae","volume":"101","author":"Liaw","year":"2016","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e00238","DOI":"10.1002\/hlca.202500238","article-title":"Chemotaxonomic Classification of Annonaceae Species From Herbarium Samples Using LC-HRMS, Supported by Multivariate Curve Resolution Applied to Regions of Interest (ROIMCR)","volume":"109","author":"Wisson","year":"2026","journal-title":"Helv. Chim. Acta"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jare.2023.11.003","article-title":"Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application","volume":"63","author":"Sun","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.17129\/botsci.3780","article-title":"An overview of secondary metabolites in Mexican Annonaceae","volume":"104","year":"2026","journal-title":"Bot. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Al Kazman, B.S.M., Harnett, J.E., and Hanrahan, J.R. (2022). Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae. Molecules, 27.","DOI":"10.3390\/molecules27113462"},{"key":"ref_26","unstructured":"Preedy, V.R. (2016). Annona Species (Annonaceae) Oils. Essential Oils in Food Preservation, Flavor and Safety, Academic Press."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., La Torre, C., Ceramella, J., Mallamaci, R., Saturnino, C., Iacopetta, D., and Sinicropi, M.S. (2019). \u03b2-Caryophyllene: A Sesquiterpene with Countless Biological Properties. Appl. Sci., 9.","DOI":"10.3390\/app9245420"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gull\u00ec, M., Percaccio, E., Di Giacomo, S., and Di Sotto, A. (2022). Novel Insights into the Immunomodulatory Effects of Caryophyllane Sesquiterpenes: A Systematic Review of Preclinical Studies. Appl. Sci., 12.","DOI":"10.3390\/app12052292"},{"key":"ref_29","first-page":"e-20230101","article-title":"Chemical composition, biological activities and uses of Anacardiaceae species: An updated review","volume":"47","author":"Cunha","year":"2024","journal-title":"Quim. Nova"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19220","DOI":"10.1021\/acsomega.5c12447","article-title":"Chemical Profiling and Cosmetic Potential from Anacardium humile and Anacardium occidentale","volume":"11","author":"Silva","year":"2026","journal-title":"ACS Omega"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.2174\/0115680266319575240905164313","article-title":"From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential","volume":"25","author":"Araujo","year":"2025","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ferreyra, M.L.F., Rius, S., and Casati, P. (2012). Flavonoids: Biosynthesis, biological functions, and biotechnological applications. Front. Plant Sci., 3.","DOI":"10.3389\/fpls.2012.00222"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.sajb.2025.12.003","article-title":"Targeted metabolomic approach to elucidate flavonoid profiles employing LC-MS\/MS in leaves and pseudo-fruit of Indian Cashew cultivars (Anacardium occidentale L.)","volume":"189","author":"Narayanappa","year":"2026","journal-title":"S. Afr. J. Bot."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"108675","DOI":"10.1016\/j.jddst.2026.108675","article-title":"Delivery systems based on cashew tree by-products (Anacardium occidentale): Applications and sustainability\u2014A review","volume":"125","author":"Sena","year":"2026","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Salehi, B., G\u00fcltekin-\u00d6zg\u00fcven, M., K\u0131rk\u0131n, C., \u00d6z\u00e7elik, B., Morais-Braga, M.F.B., Carneiro, J.N.P., Bezerra, C.F., Silva, T.G., Coutinho, H.D.M., and Amina, B. (2019). Anacardium Plants: Chemical, Nutritional Composition and Biotechnological Applications. Biomolecules, 9.","DOI":"10.3390\/biom9090465"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sousa, J.M.S., Nunes, T.A.L., Rodrigues, R.R.L., Sousa, J.P.A., Val, M.d.C.A., Coelho, F.A.R., Santos, A.L.S., Maciel, N.B., Souza, V.M.R., and Machado, Y.A.A. (2023). Cytotoxic and Antileishmanial Effects of the Monoterpene \u03b2-Ocimene. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020183"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Farr\u00e9-Armengol, G., Filella, I., Llusi\u00e0, J., and Pe\u00f1uelas, J. (2017). \u03b2-Ocimene, a Key Floral and Foliar Volatile Involved in Multiple Interactions between Plants and Other Organisms. Molecules, 22.","DOI":"10.3390\/molecules22071148"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s11101-024-09914-2","article-title":"Asclepiadoideae subfamily (Apocynaceae): Ethnopharmacology, biological activities and chemophenetics based on pregnane glycosides","volume":"23","author":"Souza","year":"2024","journal-title":"Phytochem. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kaur, A., Batish, D.R., Kaur, S., and Chauhan, B.S. (2021). An Overview of the Characteristics and Potential of Calotropis procera From Botanical, Ecological, and Economic Perspectives. Front. Plant Sci., 12.","DOI":"10.3389\/fpls.2021.690806"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"35854","DOI":"10.1039\/D1RA06703F","article-title":"A review on phytochemical constituents and pharmacological potential of Calotropis procera","volume":"11","author":"Wadhwani","year":"2021","journal-title":"RSC Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.51477\/mejs.1196088","article-title":"Determination of some bioactivities of Convallaria majalis L. (Lily of the Valley), isolation pharmaceutical active ingredient and investigation its industrial useage","volume":"8","author":"Demir","year":"2022","journal-title":"Middle East. J. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"NP48","DOI":"10.1177\/12034754251341852","article-title":"Treatment Approaches for Common Dermatological Conditions","volume":"29","author":"Dababneh","year":"2025","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Magalh\u00e3es, D.W.A., Sidr\u00f4nio, M.G.S., Nogueira, N.N.A., Carvalho, D.C.M., Freitas, M.E.G., Oliveira, E.C., Frazao Lima, G.F., Ara\u00fajo, D.A.M., Scavone, C., and Souza, T.A. (2025). Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid \u03b3-Benzylidene Digoxin-15 in Macrophage Models of Infection. Microorganisms, 13.","DOI":"10.3390\/microorganisms13020269"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Al-Rowaily, S.L., Abd-ElGawad, A.M., Assaeed, A.M., Elgamal, A.M., Gendy, A.E.-N.G.E., Mohamed, T.A., Dar, B.A., Mohamed, T.K., and Elshamy, A.I. (2020). Essential Oil of Calotropis procera: Comparative Chemical Profiles, Antimicrobial Activity, and Allelopathic Potential on Weeds. Molecules, 25.","DOI":"10.3390\/molecules25215203"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Dourado, D., Miranda, J.A., Oliveira, M.C., Freire, D.T., Xavier-J\u00fanior, F.H., Paredes-Gamero, E.J., and Alencar, \u00c9.N. (2024). Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020177"},{"key":"ref_46","unstructured":"Wang, X., Ao, H., Li, H., Wang, Y.a., Guo, Y., and Han, M. (2019). Annona squamosal Seed Extract for Treating Choriocarcinoma, Preparation Method Therefor and Application Thereof. (CN109793732B)."},{"key":"ref_47","unstructured":"Li, X., Ma, C., and Chen, J. (2017). Epoxy Type Annonaceous Acetogenin Compound with Antitumor Activity and Preparation Method and Application Thereof. (CN106543159)."},{"key":"ref_48","unstructured":"Li, X., Ma, C., and Chen, J. (2017). M-Bistetrahydrofuran Annonaceous Acetogenins Compound with Anti-Tumor Activity and Preparation Method and Application Thereof. (CN106543117)."},{"key":"ref_49","unstructured":"Li, X., Ma, C., and Chen, J. (2017). O-bis-Tetrahydrofuran Type Annonaceous Acetogenins Compound Having Antitumor Activity, Preparation Method, and Application Thereof. (CN106749124)."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1080\/14786419.2022.2134362","article-title":"Three new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa","volume":"38","author":"Ma","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100295","DOI":"10.1016\/j.phanu.2022.100295","article-title":"Acetogenins from Annonaceae plants: Potent antitumor and neurotoxic compounds","volume":"20","author":"Lima","year":"2022","journal-title":"PharmaNutrition"},{"key":"ref_52","unstructured":"Chen, Y. (2021). Compound with Anti-Tumor Activity as well as Preparation Method and Application Thereof. (CN113801000)."},{"key":"ref_53","unstructured":"Chen, Y., Wu, X., Lin, L., and Chen, H. (2022). Enantio-Kaurane Diterpenoid Compound with Anti-Tumor Activity as well as Preparation Method and Application of Enantio-Kaurane Diterpenoid Compound. (CN114671759)."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1080\/14786419.2022.2027408","article-title":"New ent-kaurene-type nor-diterpene and other compounds isolated from Annona vepretorum Mart. (Annonaceae)","volume":"37","author":"Nery","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_55","unstructured":"Li, X., Chen, Y., and Chen, J. (2017). Sweetsop Peel Volatile Oil Extract with Anti-Tumor Activity as well as Preparation Method and Application Thereof. (CN106309516)."},{"key":"ref_56","unstructured":"Wang, H., Liu, Y., An, Z., and Gong, Y. (2022). Waste Fruit Peel Extract Composition with Effect of Treating Gastric Cancer. (CN114558053)."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114147","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_58","unstructured":"Rana, J., and Mitchell, K. (2021). Anti-Inflammatory Botanical Extract. (EP3843762)."},{"key":"ref_59","unstructured":"Chen, Z., and Wang, H. (2020). Gargle for Relieving Oral Wound Pain and Preparation Method Thereof. (CN112057387)."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1177\/1535370215576299","article-title":"Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice","volume":"240","author":"Vasconcelos","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1007\/s10787-025-01781-3","article-title":"Evaluation of anti-inflammatory and anti-oxidant properties of Anacardium occidentale leaf","volume":"33","author":"Anorue","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Siracusa, R., Fusco, R., Peritore, A.F., Cordaro, M., D\u2019Amico, R., Genovese, T., Gugliandolo, E., Crupi, R., Smeriglio, A., and Mandalari, G. (2020). The Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale L. Cashew Nuts in a Mouse Model of Colitis. Nutrients, 12.","DOI":"10.3390\/nu12030834"},{"key":"ref_63","unstructured":"Awaad, A.S., Zain, G.M., El-Meligy, R.M., Alkanhal, H.F., and Seshadri, V.D. (2017). Calotropis Procera Extracts as Anti-Ulcerative Colitis Agents. (9533019), U.S. Patent."},{"key":"ref_64","unstructured":"Meital, P.C., Zeevi, M., Eliran, I.-S., and Dror, C. (2022). Compositions Comprising Dead Sea Extract and an Extract of Apple of Sodom and Uses Thereof. (11400126), U.S. Patent."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.53388\/BMEC2024021","article-title":"Calotropis procera: A review of molecular mechanisms, bioavailability, and potential anticancer property","volume":"3","author":"Nawaz","year":"2024","journal-title":"Biomed. Eng. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"115503","DOI":"10.1016\/j.jep.2022.115503","article-title":"Anti-inflammatory and antioxidant effect of methanol extract of latex of Calotropis procera in rat model of colorectal cancer","volume":"296","author":"Kumar","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_67","unstructured":"Suresh, V., Subhashini, A.S., Chamundeeswari, D.P., and Thyagarajan, S.P. (2016). A Pharmaceutical Formulation for Treating Diabetes Mellitus and Its Associated Complications. (IN5274\/CHE\/2013)."},{"key":"ref_68","unstructured":"Lim, Y.S., Kim, S.Y., Lee, H.J., Son, Y.S., and Kim, J.S. (2022). Pharmaceutical Composition and Health Functional Food Comprising Graviola Leaf Extract. (KR102559349)."},{"key":"ref_69","unstructured":"Chen, L. (2015). Black Sesame-Sweetsop Health-Preserving Wine and Preparation Method Thereof. (CN104293562)."},{"key":"ref_70","unstructured":"Yue, Y., Han, Y., and Yi, B. (2021). Composition for Enhancing Immunity as well as Preparation Technology and Application Thereof. (CN113244372)."},{"key":"ref_71","unstructured":"Park, T.S., Shim, S.M., and Kim, G.T. (2017). Method for Manufacturing Graviola Extract and Pharmaceutical Composition for Immune Enhancement. (KR101951854)."},{"key":"ref_72","unstructured":"Tian, X., and Dong, X. (2024). Composition Containing Cistanche Deserticola Extract as well as Preparation Method and Application of Composition. (CN118593682)."},{"key":"ref_73","unstructured":"Gong, Y., Gong, Y., Wang, H., and Jin, H. (2022). Extract Composition with Effects of Protecting Liver and Lowering Transaminase. (CN114504615)."},{"key":"ref_74","unstructured":"Coral, J.G.C. (2015). Composition for Treating Hepatitis Containing an Extract of Cordia Lutea Flowers, Annona muricata Leaves, and Curcuma Longa Roots. (9775871), U.S. Patent."},{"key":"ref_75","unstructured":"Wang, T., Wu, H., Yu, M., and Yu, N. (2019). Pharmaceutical Composition for Treating or Preventing Nerve Damage. (CN110075274)."},{"key":"ref_76","unstructured":"Hayashi, K., and Lee, D.-Y. (2019). Muscle Activator. (JP7209207)."},{"key":"ref_77","unstructured":"Ramos, G.A., Lemes, L.F.N., Romeiro, L.A.S., Romeiro, N.C., and Castro, N.G. (2015). Amino Derivatives of LCC as Acetylcholinesterase Inhibitors, Processes for Their Production, Pharmaceutical Compositions Containing Them and Applications. (BR102013012924)."},{"key":"ref_78","unstructured":"Peng, H. (2016). Health Maintaining and Kidney Tonifying Chinese Chestnut Baijiu and Preparation Method Thereof. (CN105733899)."},{"key":"ref_79","unstructured":"Cruz, R.D. (2015). A Herbal Cream Preparation that Cauterizes and Removes Condyloma Acuminata on Genital Warts and the Likes. (PH12013000108)."},{"key":"ref_80","unstructured":"Liu, Y., Liu, S., Wen, X., Wang, Z., Zhao, D., Song, W., and Wang, J. (2023). Plant Extract Pharmaceutical Composition for Improving Secretion of Endogenous Insulin-Like Growth Factor 1. (CN117257891)."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Usai, R., Majoni, S., and Rwere, F. (2022). Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.980819"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Vaou, N., Stavropoulou, E., Voidarou, C.C., Tsakris, Z., Rozos, G., Tsigalou, C., and Bezirtzoglou, E. (2022). Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects. Antibiotics, 11.","DOI":"10.3390\/antibiotics11081014"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","article-title":"Liver diseases: Epidemiology, causes, trends and predictions","volume":"10","author":"Gan","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"100469","DOI":"10.1016\/j.phanu.2025.100469","article-title":"Levisticum officinale essential oil prevents paracetamol-induced hepatotoxicity by decreasing oxidative stress","volume":"36","author":"Basilio","year":"2026","journal-title":"PharmaNutrition"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3892\/br.2024.1854","article-title":"Optimization of antioxidant activity of soursop (Annona muricata L.) leaf extract using response surface methodology","volume":"21","author":"Hartati","year":"2024","journal-title":"Biomed. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"150","DOI":"10.9734\/jpri\/2021\/v33i62B35181","article-title":"Hepatoprotective effect of Annona squamosa Linn. (AS) leaves on isoniazid & rifampin induced hepatotoxicity in rats","volume":"33","author":"Derangula","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Gasmi, A., Shanaida, M., Oleshchuk, O., Semenova, Y., Mujawdiya, P.K., Ivankiv, Y., Pokryshko, O., Noor, S., Piscopo, S., and Adamiv, S. (2023). Natural Ingredients to Improve Immunity. Pharmaceuticals, 16.","DOI":"10.3390\/ph16040528"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"129","DOI":"10.9734\/ejnfs\/2024\/v16i101563","article-title":"Custard Apple (Annona squamosa L.): Exploring its Health Benefits and Medicinal Properties","volume":"16","author":"Gautam","year":"2024","journal-title":"Eur. J. Nutr. Food Saf."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1111\/ijfs.15543","article-title":"Bioactive peptides from nuts: A review","volume":"57","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13237-022-00405-3","article-title":"Plant-derived natural products for drug discovery: Current approaches and prospects","volume":"65","author":"Nasim","year":"2022","journal-title":"Nucleus"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhou, P., Zhang, R., Xian, L., Ning, L., Lu, P., Liu, Q., and Liu, M. (2025). Selection of sciatic nerve injury models: Implications for pathogenesis and treatment. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1521941"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1039\/D1MD00046B","article-title":"Discovery of sustainable drugs for Alzheimer\u2019s disease: Cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties","volume":"12","author":"Ramos","year":"2021","journal-title":"RSC Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: From molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Bj\u00f8rklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sarac, I., Strus, O., Smetanina, K., and Chirumbolo, S. (2022). Natural Compounds and Products from an Anti-Aging Perspective. Molecules, 27.","DOI":"10.3390\/molecules27207084"},{"key":"ref_95","unstructured":"Liang, C.-H., Chan, L.-P., Chen, P.-J., and Liu, C.-C. (2021). Annona Montana Macf Leaves Extract for Anti-Oxidant, Anti-Inflammation, Whitening, Repairing and Anti-Wrinkle. (TWI774339)."},{"key":"ref_96","unstructured":"Leu, K.-L., and Chang, C.-L. (2021). Use of Annona squamosa L. Peel Extract in Preparation of Composition for Inhibiting Matrix Metalloproteinase, Hyaluronidase, Lipoxygenase activity and Nitric oxide Generation. (TWI814026)."},{"key":"ref_97","unstructured":"Moh, S.H., Lee, J.H., Jung, H.S., Song, M.Y., Kim, S.Y., and Moh, J.H. (2015). Anti-Aging Composition for Skin External Application Comprising Annona squamosa Placenta Culture Extracts. (KR101619709)."},{"key":"ref_98","unstructured":"He, Q., Luo, T., Kong, X., Huang, J., Yi, X., and Cao, H. (2021). Cosmetic Containing Custard Apple Multiple Fermentation Liquor and Preparation Method Thereof. (CN113041200)."},{"key":"ref_99","unstructured":"Lin, Y.H., and Li, S. (2020). Application of Annona squamosa Leavening in Preparation of Composition. (CN111956536)."},{"key":"ref_100","unstructured":"Lee, H.K. (2022). Cosmetic Composition. (KR102436816)."},{"key":"ref_101","unstructured":"Choung, E.S., Yun, J.U., Park, M.H., Kim, H.B., and Joung, Y.J. (2016). Cosmetic Composition Containing Fermented Graviola for Improving Anti-Wrinkle and Method of Preparing the Same. (KR101648148)."},{"key":"ref_102","unstructured":"Cha, W.H., Jin, S.M., Kim, M.J., and Kim, J.H. (2018). Cosmetic Composition Containing the Extraction Mixture. (KR101999885)."},{"key":"ref_103","unstructured":"Song, C.S., Ryu, M.Y., and Jo, J.E. (2018). Cosmetic Composition for Anti-Oxidation Anti-Inflammatory and Anti-Wrinkling Comprising Enzyme-Treated Extracts of Annona muricata and Method for Manufacturing the Same. (KR101868507)."},{"key":"ref_104","unstructured":"Choi, W. (2017). Cosmetic Composition for Silver Generation for Improving Skin Winkles and maskpack Sheet Using the Same. (KR101774408)."},{"key":"ref_105","unstructured":"Rana, J., and Mitchell, K. (2021). Botanical Antioxidants. (EP3843557)."},{"key":"ref_106","unstructured":"Moon, K.K., Hong, J.Y., Lee, C.E., and Im, D.B. (2023). Cosmetic Composition Including as Effective Ingredient an Nanoemulsion of Cashew Seed Oil. (KR102726643)."},{"key":"ref_107","unstructured":"Kim, E.M., Kim, M.S., Song, S.Y., Lee, Y.M., Lee, K.Y., Yoo, A.Y., and Kwak, M.J. (2024). Cosmetic Composition for Improving Skin Wrinkle Anti-Inflammation and Moisturizing Containing the Complex Extracts of Morus Bombycis Leaf Polygonum Fagopyrum Seed Moringa oleifera Seed and Anacardium occidentale. (KR102693360)."},{"key":"ref_108","unstructured":"Rana, J., and Mitchell, K. (2020). Botanical Extract for Skin Care. (10967022), U.S. Patent."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Karimi, N. (2023). Approaches in line with human physiology to prevent skin aging. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1279371"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Shin, S.H., Lee, Y.H., Rho, N.-K., and Park, K.Y. (2023). Skin aging from mechanisms to interventions: Focusing on dermal aging. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1195272"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biopha.2018.01.172","article-title":"Annona muricata Linn. leaf as a source of antioxidant compounds with in vitro antidiabetic and inhibitory potential against \u03b1-amylase, \u03b1-glucosidase, lipase, non-enzymatic glycation and lipid peroxidation","volume":"100","author":"Justino","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Ponce-Mora, A., Gimeno-Mallench, L., Lavandera, J.L., Giebelhaus, R.T., Domenech-Benda\u00f1a, A., Locascio, A., Gutierrez-Rojas, I., Sauro, S., de la Mata, P., and Nam, S.L. (2025). Systematic Characterization of Antioxidant Shielding Capacity Against Oxidative Stress of Aerial Part Extracts of Anacardium occidentale. Antioxidants, 14.","DOI":"10.20944\/preprints202506.2542.v1"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"107752","DOI":"10.1016\/j.carres.2019.107752","article-title":"Pectins from cashew apple fruit (Anacardium occidentale): Extraction and chemical characterization","volume":"483","author":"Iacomini","year":"2019","journal-title":"Carbohydr. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e371006","DOI":"10.1590\/acb371006","article-title":"Anacardium occidentale L. cajueiro in the healing of skin wounds: An experimental study in rats","volume":"37","author":"Silva","year":"2022","journal-title":"Acta Cir. Bras."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.3762\/bjnano.16.132","article-title":"Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: A review with focus on larvicidal and repellent properties","volume":"16","author":"Silva","year":"2025","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.tibtech.2022.12.020","article-title":"The booming business of hair loss","volume":"41","author":"Castro","year":"2023","journal-title":"Trends Biotechnol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Choi, J.Y., Boo, M.Y., and Boo, Y.C. (2024). Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets. Molecules, 29.","DOI":"10.3390\/molecules29102288"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Anudeep, T.C., Jeyaraman, M., Muthu, S., Rajendran, R.L., Gangadaran, P., Mishra, P.C., Sharma, S., Jha, S.K., and Ahn, B.-C. (2022). Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14030612"},{"key":"ref_119","unstructured":"Hong, Y.H. (2020). 2 Manufacturing Method of Hair Loss Prevention Shampoo Containing Graviola Component Extracted in Two Steps. (KR102143154)."},{"key":"ref_120","unstructured":"Byun, Y.M., Kim, J.G., Lee, J.H., and Kim, S.K. (2023). Fermented Product of Medical Herbs for Preventing, Ameliorating, or Protecting Against Hair Loss, and Use Thereof. (KR102585336)."},{"key":"ref_121","unstructured":"Hwang, I.S. (2015). Method for Producing Natural Extract with Increased Alopecia Prevention Effect and Shampoo for Preventing Alopecia Containing Natural Extract Produced by Same Method. (KR101540333)."},{"key":"ref_122","unstructured":"Lee, J.M. (2020). Shampoo Comprising the Extract of Graviola for Improving Condition of Scalp and Preventing Hair Loss. (KR102080412)."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5530\/pj.2022.14.49","article-title":"The Potential of Moringa (Moringa oleifera Lamk) Seed Oil as Anti- Alopecia","volume":"14","author":"Korassa","year":"2022","journal-title":"Pharmacogn. J."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Choi, B.Y. (2018). Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092703"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Williams, S.N., Webb, T., Lohiniva, A.-L., Jardan, E., Onyon, L., and Altieri, E. (2026). Why are people cosmetic skin whitening? A systematic review. BMC Public. Health, 26.","DOI":"10.1186\/s12889-026-26649-1"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1111\/jocd.15437","article-title":"Potential application of natural bioactive compounds as skin-whitening agents: A review","volume":"21","author":"Zhao","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e70113","DOI":"10.1002\/ddr.70113","article-title":"Clinical Investigation of Tyrosinase Inhibitors: Past, Present, and Future","volume":"86","author":"Wang","year":"2025","journal-title":"Drug Dev. Res."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Hassan, M., Shahzadi, S., and Kloczkowski, A. (2023). Tyrosinase Inhibitors Naturally Present in Plants and Synthetic Modifications of These Natural Products as Anti-Melanogenic Agents: A Review. Molecules, 28.","DOI":"10.3390\/molecules28010378"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s13659-022-00363-y","article-title":"Natural products in cosmetics","volume":"12","author":"Liu","year":"2022","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_130","unstructured":"Lin, Y.-H., and Lin, H.-Y. (2022). Use of Bioactive Compounds of Annona muricata Ferment for Preparing a Composition of Inhibiting Melanin Production and Enhancing anti-Oxidation Capacity of THP-1 Cells. (TWI817363)."},{"key":"ref_131","unstructured":"Jung, D.H., Kim, S.J., Kim, S., Chu, S.J., Sung, J.Y., Lim, C.I., and Jung, S.H. (2024). Composition Comprising Graviola Callus Lysate Extract as an Active Ingredient Having Skin Whitening Antioxidant Skin Condition Improvement and Hair Loss Inhibitory Effects. (KR102676679)."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s41702-017-0010-7","article-title":"Annona muricata L. extracts decrease melanogenesis in B16F10 mouse melanoma cells","volume":"1","author":"Joo","year":"2017","journal-title":"Biomed. Dermatol."},{"key":"ref_133","unstructured":"Gao, L., Xie, Y., He, R., Feng, C., Liu, W., and Li, J. (2024). Whitening Composition. (CN118512378)."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Srisuksomwong, P., Kaenhin, L., and Mungmai, L. (2023). Collagenase and Tyrosinase Inhibitory Activities and Stability of Facial Cream Formulation Containing Cashew Leaf Extract. Cosmetics, 10.","DOI":"10.3390\/cosmetics10010017"},{"key":"ref_135","unstructured":"Lee, Y.J., Jang, K.H., Jeon, A.J., Lee, H.J., Kim, D.Y., Hong, I.K., and Cho, S.H. (2018). Cosmetic Compositions Containing Niosomes of Graviola Extract. (KR101844673)."},{"key":"ref_136","unstructured":"Gyu, L.H., and Hee, J.C. (2017). Mask Cosmetic Composition Comprising Graviola Antibiotic Extract for Skin Anti-Wrinkle and Method of Preparing the Same. (KR102475897)."},{"key":"ref_137","unstructured":"Gyu, L.H., and Hee, J.C. (2017). Skin Vital Rising Cosmetic Composition Comprising Graviola Antibiotic Extract and Method of Preparing the Same. (KR102475898)."},{"key":"ref_138","unstructured":"Sun, Q., Li, A., and Li, S. (2021). Moisturizing, Anti-Wrinkle, Nourishing and Skin-Care Gel and Preparation Method Thereof. (CN113368026)."},{"key":"ref_139","unstructured":"Kim, C.O. (2024). Cosmetic Composition for Preventing and Improving Skin Damage Caused by Ultraviolet Rays and Method for Manufacturing the Same. (KR102679087)."},{"key":"ref_140","unstructured":"Opatz, T., K\u00fchlborn, J., De Koning, C.B., Ngwira, K.J., and Mgani, Q.A. (2021). Compounds Having Excited State Intramolecular Proton Transfer (Esipt) Character for Use in Treating and\/or Preventing Sunburn and\/or Preventing u.v. Damage. (AU2020234097)."},{"key":"ref_141","unstructured":"Xue, B.E., Zhang, H., Li, Y., Guo, W., Liao, B., and Wang, Y. (2022). Male Conditioning Essence and Preparation Method Thereof. (CN114515261)."},{"key":"ref_142","unstructured":"Kim, M.M., Yunghee, O., Lee, K., Jang, J., Yoon, H., Ha, Y., Jeon, S., Kim, J.H., Kim, J., and Park, S. (2019). A Composition Comprising Graviola Having Inhibitory Effect on Induction of Grey Hair and Positive Effect on Induction of Black Hair. (KR102030419)."},{"key":"ref_143","unstructured":"Combet, J.F. (2017). Preparation d\u2019une Levure Acetobacter et sa Mise en Evidence. (FR3051363)."},{"key":"ref_144","unstructured":"Yamada, M., Mikoshiba, K., and Manji, R. (2015). Hair Dye and Hair Dyeing Method. (JP6049830)."},{"key":"ref_145","unstructured":"Jang, H.D., Lee, D.K., Kim, J.H., Kim, C.W., and Park, J.W. (2019). Natural Cosmetic Composition Using Aronia. (KR101957351)."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"106380","DOI":"10.1016\/j.jddst.2024.106380","article-title":"Nanotools as potential approach in effective management of acne","volume":"102","author":"Darvishi","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.2021.17633","article-title":"Management of Acne Vulgaris: A Review","volume":"326","author":"Eichenfield","year":"2021","journal-title":"JAMA"},{"key":"ref_148","first-page":"1","article-title":"Acne vulgaris: New evidence in pathogenesis and future modalities of treatment","volume":"32","author":"Hazarika","year":"2019","journal-title":"J. Dermatol. Treat."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Wahab, S.M.A., Jantan, I., Haque, M.A., and Arshad, L. (2018). Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00661"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Aguilar-Hern\u00e1ndez, G., L\u00f3pez-Romero, B.A., P\u00e9rez-Larios, A., Ruvalcaba-G\u00f3mez, J.M., Castellanos-Huerta, I., Tellez-Isaias, G., Petrone-Garc\u00eda, V.M., Anaya-Esparza, L.M., and Montalvo-Gonz\u00e1lez, E. (2023). Antibacterial Activity of Crude Extract and Purified Acetogenins from Annona muricata Seeds. Appl. Sci., 13.","DOI":"10.3390\/app13010558"},{"key":"ref_151","first-page":"43","article-title":"Formulation and Effectiveness Test of 96% Ethanol Extract Anti-Acne Serum Cashew Leaves (Anacardium occidentale L.)","volume":"2","author":"Dwiastuti","year":"2024","journal-title":"Sci. J. Dermatol. Venereol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Miranda, J.A., Cruz, Y.F., Gir\u00e3o, \u00cd.C., Souza, F.J.J., Oliveira, W.N., Alencar, \u00c9.N., Amaral-Machado, L., and Egito, E.S.T. (2024). Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16050661"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Lens, M. (2025). Niosomes as Vesicular Nanocarriers in Cosmetics: Characterisation, Development and Efficacy. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17030287"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Pizano-Andrade, J.C., Vargas-Guerrero, B., Vargas-Radillo, J., Dom\u00ednguez-Rosales, J.A., Montalvo-Gonz\u00e1lez, E., Rodriguez-Macias, R., Garcia-L\u00f3pez, P.M., Rocio Romero-Verd\u00edn, M., and Ruiz L\u00f3pez, M.A. (2025). Photoprotective Effect of Annona muricata L. Extracts in Rats Exposed to Ultraviolet Radiation via P53 and RB Gene Expression. Molecules, 30.","DOI":"10.3390\/molecules30173518"},{"key":"ref_155","first-page":"204","article-title":"Plants from Brazil with Potential Photoprotective Activity: A Review","volume":"17","author":"Silva","year":"2023","journal-title":"Phcog. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4103\/pm.pm_482_18","article-title":"Photoprotective activity of medicinal plants from the caatinga used as anti-inflammatories","volume":"15","author":"Andrade","year":"2019","journal-title":"Pharmacogn. Mag."},{"key":"ref_157","unstructured":"(2019). Cosmetics\u2014Sun Protection Test Methods\u2014In Vivo Determination Of The Sun Protection Factor (SPF). Edition 2 (Standard No. ISO 24444:2019)."},{"key":"ref_158","unstructured":"European Commission (2007). The Euro: Benefiting Weak and Strong Economies Together, European Commission."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1007\/s13197-014-1289-7","article-title":"Antioxidant, DNA protective efficacy and HPLC analysis of Annona muricata (soursop) extracts","volume":"52","author":"George","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Balderrama-Carmona, A.P., Silva-Beltr\u00e1n, N.P., G\u00e1lvez-Ruiz, J.C., Ru\u00edz-Cruz, S., Chaidez-Quiroz, C., and Mor\u00e1n-Palacio, E.F. (2020). Antiviral, Antioxidant, and Antihemolytic Effect of Annona muricata L. Leaves Extracts. Plants, 9.","DOI":"10.3390\/plants9121650"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Kumar, M., Changan, S., Tomar, M., Prajapati, U., Saurabh, V., Hasan, M., Sasi, M., Maheshwari, C., Singh, S., and Dhumal, S. (2021). Custard Apple (Annona squamosa L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Biological Activities. Biomolecules, 11.","DOI":"10.3390\/biom11050614"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1111\/geb.13563","article-title":"Compound impact of land use and extreme climate on the 2020 fire record of the Brazilian Pantanal","volume":"31","author":"Barbosa","year":"2022","journal-title":"Glob. Ecol. Biogeogr."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Dzhemileva, L.U., Tuktarova, R.A., Dzhemilev, U.M., and D\u2019yakonov, V.A. (2023). Natural Acetogenins, Chatenaytrienins-1, -2, -3 and -4, Mitochondrial Potential Uncouplers and Autophagy Inducers\u2014Promising Anticancer Agents. Antioxidants, 12.","DOI":"10.3390\/antiox12081528"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/jcor.jcor_11_20","article-title":"Spectrum of Calotropis procera latex-induced ocular toxicity","volume":"8","author":"Bahkir","year":"2020","journal-title":"J. Clin. Ophthalmol. Res."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Ponce, A., Flores-Maldonado, C., and Contreras, R.G. (2025). Cardiac Glycosides: From Natural Defense Molecules to Emerging Therapeutic Agents. Biomolecules, 15.","DOI":"10.3390\/biom15060885"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/17\/2632\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T04:27:52Z","timestamp":1788064072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/17\/2632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":165,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["plants15172632"],"URL":"https:\/\/doi.org\/10.3390\/plants15172632","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}