{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:20:53Z","timestamp":1788456053834,"version":"build-2803163510"},"reference-count":32,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Diabetes mellitus is a major global health challenge, and medicinal plants represent an important source of bioactive compounds with therapeutic potential. Ibervillea sonorae (S. Watson) Greene is traditionally used in Mexican medicine for diabetes management and has attracted increasing scientific interest because of its reported antihyperglycemic activity. This systematic review critically evaluated the available preclinical evidence regarding the antihyperglycemic effects of I. sonorae, its proposed molecular mechanisms, phytochemical context, and methodological limitations. Following the PRISMA 2020 guidelines, PubMed, Scopus, and Google Scholar were searched for studies published between January 2010 and February 2026. Eight studies met the inclusion criteria, including animal, cellular, and enzyme-based models. The available evidence indicates that I. sonorae preparations may improve glycemic control through complementary mechanisms involving enhanced glucose uptake and insulin-related responses, including participation of the PI3K\/AKT\/GLUT4 signaling network, together with inhibition of \u03b1-glucosidase and \u03b1-amylase activity. AMPK-related mechanisms remain biologically plausible but have not been directly established across the included studies. Phytochemical evidence identifies cucurbitacin-derived constituents, including kinoins, as potentially relevant bioactive compounds; however, most mechanistic findings were obtained using crude extracts or other plant preparations, and their specific contribution cannot yet be attributed to individual constituents. Overall, this review integrates the fragmented preclinical evidence and identifies the principal mechanistic, phytochemical, and methodological gaps that must be addressed before clinical translation. I. sonorae represents a promising candidate for antihyperglycemic research, although phytochemical standardization, rigorous mechanistic studies, comprehensive safety evaluation, and well-designed clinical investigations are required to establish its therapeutic efficacy and safety.<\/jats:p>","DOI":"10.3390\/plants15172710","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:21:21Z","timestamp":1788452481000},"page":"2710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antihyperglycemic Effects and Molecular Mechanisms of Ibervillea sonorae (S. Watson) Greene: A Systematic Review of Preclinical Evidence"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8041-603X","authenticated-orcid":false,"given":"Vanessa Wendi","family":"Su\u00e1rez-Barrios","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lilia","family":"Hern\u00e1ndez-Alba","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-2304","authenticated-orcid":false,"given":"Juan Gabriel","family":"Ju\u00e1rez-Rojas","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-0685","authenticated-orcid":false,"given":"Abraham S.","family":"Arellano-Buendia","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Pathophysiology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2004","DOI":"10.1002\/hsr2.2004","article-title":"Diabetes Mellitus, the Fastest Growing Global Public Health Concern: Early Detection Should Be Focused","volume":"7","author":"Hossain","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Krause, M., and De Vito, G. (2023). Type 1 and Type 2 Diabetes Mellitus: Commonalities, Differences and the Importance of Exercise and Nutrition. Nutrients, 15.","DOI":"10.3390\/nu15194279"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Yedjou, C.G., Grigsby, J., Mbemi, A., Nelson, D., Mildort, B., Latinwo, L., and Tchounwou, P.B. (2023). The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109085"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.sajb.2019.07.029","article-title":"Antioxidant, Anti-Inflammatory and Antiproliferative Properties of Ibervillea sonorae","volume":"125","year":"2019","journal-title":"S. Afr. J. Bot."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Huerta-Reyes, M., Tavera-Hern\u00e1ndez, R., Alvarado-Sansininea, J.J., and Jim\u00e9nez-Estrada, M. (2022). Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus. Molecules, 27.","DOI":"10.3390\/molecules27113440"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yetman, D., and Van Devender, T.R. (2002). Mayo Ethnobotany: Land, History, and Traditional Knowledge in Northwest Mexico, University of California Press.","DOI":"10.1525\/california\/9780520227217.001.0001"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Delgado-Tiburcio, E.E., Cadena-I\u00f1iguez, J., Santiago-Osorio, E., Ruiz-Posadas, L.d.M., Castillo-Ju\u00e1rez, I., Agui\u00f1iga-S\u00e1nchez, I., and Soto-Hern\u00e1ndez, M. (2022). Pharmacokinetics and Biological Activity of Cucurbitacins. Pharmaceuticals, 15.","DOI":"10.3390\/ph15111325"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zagoskina, N.V., Zubova, M.Y., Nechaeva, T.L., Kazantseva, V.V., Goncharuk, E.A., Katanskaya, V.M., Baranova, E.N., and Aksenova, M.A. (2023). Polyphenols in Plants: Structure, Biosynthesis, Abiotic Stress Regulation, and Practical Applications (Review). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241813874"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sahiner, M., Yilmaz, A.S., Gungor, B., Ayoubi, Y., and Sahiner, N. (2022). Therapeutic and Nutraceutical Effects of Polyphenolics from Natural Sources. Molecules, 27.","DOI":"10.3390\/molecules27196225"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Salehi, B., Valussi, M., Flaviana Bezerra Morais-Braga, M., Nalyda Pereira Carneiro, J., Linkoln Alves Borges Leal, A., Douglas Melo Coutinho, H., Vitalini, S., Kr\u0119giel, D., Antolak, H., and Sharifi-Rad, M. (2018). Tagetes Spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity. Molecules, 23.","DOI":"10.3390\/molecules23112847"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pries, R., Jeschke, S., Leichtle, A., and Bruchhage, K.L. (2023). Modes of Action of 1,8-Cineol in Infections and Inflammation. Metabolites, 13.","DOI":"10.3390\/metabo13060751"},{"key":"ref_12","first-page":"1","article-title":"Antidiabetic Potential of Extracts from Cylindropuntia imbricata (Haw.) F.M. Knuth, Opuntia engelmannii Salm-Dyck Ex Engelm., Ibervillea sonorae (S. Wats.) Greene and Theobroma cacao L.","volume":"27","year":"2024","journal-title":"TIP Rev. Espec. Cienc. Qu\u00edm.-Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"968984","DOI":"10.1155\/2011\/968984","article-title":"Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose","volume":"2011","year":"2011","journal-title":"BioMed Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100213","DOI":"10.1016\/j.phyplu.2021.100213","article-title":"Effect of Herbal Decoctions Used in Mexican Traditional Medicine Attenuate the Adverse Effects of a Hypercaloric Diet","volume":"2","author":"Salgado","year":"2022","journal-title":"Phytomed. Plus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.37360\/blacpma.23.22.1.6","article-title":"Anti-Hyperglycemic Activity of Aqueous Extracts of Cells Produced in Ibervillea sonorae (S. Watson) Green Cell Culture on Murine Model","volume":"22","year":"2023","journal-title":"Bol. Latinoam. Caribe Plantas Med. Aromat."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1007\/978-3-319-19387-8_415","article-title":"Determination of Bermang\u2019sminimal Model Parameters for Diabetic Mice Treated with Ibervillea sonorae","volume":"51","year":"2015","journal-title":"IFMBE Proc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jep.2014.01.041","article-title":"Ibervillea sonorae (Cucurbitaceae) Induces the Glucose Uptake in Human Adipocytes by Activating a PI3K-Independent Pathway","volume":"152","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100354","DOI":"10.1016\/j.hermed.2020.100354","article-title":"The Mechanisms of the Myth: Ibervillea sonorae Inhibits \u03b1-Glucosidase and Stimulates the Secretion of Insulin In Vitro","volume":"23","author":"Semotiuk","year":"2020","journal-title":"J. Herb. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2308","DOI":"10.18633\/biotecnia.v26.2308","article-title":"Fitoextractos de I. sonorae, C. limetta, and B. media Phytoextracts and Their Antidiabetic Potential","volume":"26","author":"Salgado","year":"2024","journal-title":"Biotecnia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"du Sert, N.P., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., Dirnagl, U., and Emerson, M. (2020). Reporting Animal Research: Explanation and Elaboration for the Arrive Guidelines 2.0. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000411"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/ijo.2008.116","article-title":"AMPK: A Key Regulator of Energy Balance in the Single Cell and the Whole Organism","volume":"32","author":"Hardie","year":"2008","journal-title":"Int. J. Obes."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1007\/s00018-010-0454-z","article-title":"AMP-Activated Protein Kinase and Its Downstream Transcriptional Pathways","volume":"67","author":"Auwerx","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin Signalling and the Regulation of Glucose and Lipid Metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical Nodes in Signalling Pathways: Insights into Insulin Action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cmet.2016.12.009","article-title":"Metformin Inhibits Hepatic MTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex","volume":"25","author":"Howell","year":"2017","journal-title":"Cell Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0889-8529(05)70266-8","article-title":"Alpha-Glucosidase Inhibitors","volume":"26","author":"Lebovitz","year":"1997","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and Insulin Resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and Metabolic Disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_30","unstructured":"(2026, February 09). SYRCLE RoB Tool\u2014Latitudes Network. Available online: https:\/\/www.latitudes-network.org\/tool\/syrcle-rob-tool\/."},{"key":"ref_31","unstructured":"(2026, February 09). PROSPERO. Available online: https:\/\/www.crd.york.ac.uk\/prospero\/."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yin, D., Chen, H., Lin, S., Sun, Y., Jing, X., Chang, R., Feng, Y., Dong, X., Qu, C., and Ni, J. (2025). Recent Advances in the Application of Cucurbitacin B as an Anticancer Agent. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26168003"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/17\/2710\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:36:36Z","timestamp":1788453396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/17\/2710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":32,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["plants15172710"],"URL":"https:\/\/doi.org\/10.3390\/plants15172710","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]}}}