{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:04:31Z","timestamp":1789707871582,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Exogenous glutathione (GSH) can alleviate cadmium (Cd) stress, yet physiological improvement and changes in internal Cd burden may not occur in parallel. Salix variegata seedlings were exposed for 10 d to 0 or 100 \u03bcM Cd with 0\u20131500 \u03bcM GSH. Across the full dose series, GSH responses were non-monotonic: 10 \u03bcM GSH increased root length by 67.3% under Cd stress, 250 \u03bcM GSH increased chlorophyll a, chlorophyll b, and total chlorophyll by 21.4%, 39.0%, and 25.7%, respectively, whereas 1500 \u03bcM GSH inhibited several growth and pigment traits. A common 2 \u00d7 2 subset (0\/250 \u03bcM GSH \u00d7 0\/100 \u03bcM Cd) was used to integrate root\/leaf physiology with root\/shoot element status. At 250 \u03bcM GSH, H2O2 and MDA decreased in both roots and leaves, while antioxidant and osmotic responses differed between tissues. Root Cd concentration increased by 64.1%, root Cd accumulation by 165%, and total Cd accumulation by 117%, despite a 24.1% decrease in shoot Cd concentration. Root Fe concentration and total Fe accumulation increased by 173.2% and 170%, respectively. These results show that GSH responses in S. variegata are dose- and tissue-dependent and that improved physiological status can coexist with greater Cd burden and altered essential-metal homeostasis.<\/jats:p>","DOI":"10.3390\/plants15182801","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:34:01Z","timestamp":1789378441000},"page":"2801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose-Dependent Glutathione Modulation of Physiological Responses and Metal Accumulation in Salix variegata Under Cadmium Stress"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-2136","authenticated-orcid":false,"given":"Renxiu","family":"Yao","sequence":"first","affiliation":[{"name":"School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-4527","authenticated-orcid":false,"given":"Youwei","family":"Zuo","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Long","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2544316","DOI":"10.1080\/15592324.2025.2544316","article-title":"Cadmium toxicity in plants: From transport to tolerance mechanisms","volume":"20","author":"Hu","year":"2025","journal-title":"Plant Signal. 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