{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:10:21Z","timestamp":1792789821140,"version":"4.5.0"},"reference-count":61,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32260494"],"award-info":[{"award-number":["32260494"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["32401763"],"award-info":[{"award-number":["32401763"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"award":["32260494"],"award-info":[{"award-number":["32260494"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["32401763"],"award-info":[{"award-number":["32401763"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture in Hainan University","award":["XTCX2022NYC14"],"award-info":[{"award-number":["XTCX2022NYC14"]}],"id":[{"id":"https:\/\/ror.org\/03q648j11","id-type":"ROR","asserted-by":"crossref"}]},{"award":["XTCX2022NYC14"],"award-info":[{"award-number":["XTCX2022NYC14"]}],"id":[{"id":"https:\/\/ror.org\/03q648j11","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Scientific Research Foundation of Hainan University","award":["KYQD(ZR)-22107"],"award-info":[{"award-number":["KYQD(ZR)-22107"]}],"id":[{"id":"https:\/\/ror.org\/03q648j11","id-type":"ROR","asserted-by":"crossref"}]},{"award":["KYQD(ZR)-22107"],"award-info":[{"award-number":["KYQD(ZR)-22107"]}],"id":[{"id":"https:\/\/ror.org\/03q648j11","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Cassava (Manihot esculenta Crantz) has significant economic value as a vital source of food, feed, and bio-energy. However, the production of cassava is severely restricted by cassava bacterial blight (CBB). Sirtuins (SRTs) are conserved histone deacetylases that play essential roles in the plant energy metabolism and stress response. However, the family of SRTs has not been identified in cassava. In this study, we isolated and identified three MeSRTs in response to CBB infection and found that they were negative regulators of cassava resistance using a transient gene-silencing assay. Further studies found that MeSRT1 physically interacted with the transcription factor Nuclear Factor YC15 (MeNF-YC15). Transient silencing and overexpression assays suggested that MeSRT1 negatively regulated the transcription of gibberellin 2-oxidases 1\/2 (MeGA2ox1\/2), which promoted the accumulation of gibberellic acid 1 (GA1). However, MeNF-YC15 promoted the transcription of MeGA2ox1\/2 and further increased the metabolism of GA1. Taken together, MeSRT1 and MeNF-YC15 antagonistically regulated the GA1 content and resulted in an antagonistic effect on cassava disease resistance. This study identified a MeSRT1-MeNF-YC15 molecular module in CBB resistance responses by regulating the GA1 content in cassava.<\/jats:p>","DOI":"10.3390\/plants15192898","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:21:48Z","timestamp":1790072508000},"page":"2898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MeSRT1 Interacts with MeNF-YC15 and Negatively Mediates Resistance to Cassava Bacterial Blight via Regulation of Gibberellin Metabolism in Manihot esculenta Crantz"],"prefix":"10.3390","volume":"15","author":[{"given":"Yujing","family":"Bai","sequence":"first","affiliation":[{"name":"Sanya Nanfan Research Institute of Hainan University, Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"Sanya Nanfan Research Institute of Hainan University, Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China"},{"name":"Guizhou Institute of Horticulture, Guizhou Academy of Agricultural Sciences, Guizhou Horticultural Engineering Technology Research Center, Guiyang 550006, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Yongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Sanya Nanfan Research Institute of Hainan University, Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Wenlei","family":"Yan","sequence":"additional","affiliation":[{"name":"Sanya Nanfan Research Institute of Hainan University, Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Hongqiu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Sanya Nanfan Research Institute of Hainan University, Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/tpj.16357","article-title":"Efficient sugar utilization and transition from oxidative to substrate-level phosphorylation in high starch storage roots of African cassava genotypes","volume":"116","author":"Lamm","year":"2023","journal-title":"Plant J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ntui, V.O., Tripathi, J.N., Kariuki, S.M., and Tripathi, L. (2024). Cassava molecular genetics and genomics for enhanced resistance to diseases and pests. Mol. Plant Pathol., 25, Correction in Mol. Plant Pathol. 2024, 25, e13432.","DOI":"10.1111\/mpp.13402"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Xiao, L., Cheng, D., Ou, W., Chen, X., Rabbi, I.Y., Wang, W., Li, K., and Yan, H. (2024). Advancements and strategies of genetic improvement in cassava (Manihot esculenta Crantz): From conventional to genomic approaches. Hortic. Res., 12.","DOI":"10.1093\/hr\/uhae341"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/ppa.12461","article-title":"Genetic characterization of strains named as Xanthomonas axonopodis pv. dieffenbachiae leads to a taxonomic revision of the X. axonopodis species complex","volume":"65","author":"Constantin","year":"2016","journal-title":"Plant Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1094\/MPMI-08-24-0086-R","article-title":"The XopAE effector from Xanthomonas phaseoli pv. manihotis targets HSP20-like p23 cochaperone to suppress plant basal immunity","volume":"38","author":"Castillo","year":"2025","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ppp3.70086","article-title":"Effect of seed circulation systems on the spread and diversity of Xanthomonas phaseoli pv. manihotis infecting cassava crops of the Colombian Caribbean","volume":"8","author":"Blondin","year":"2026","journal-title":"Plants People Planet"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Soto Sedano, J.C., Mora Moreno, R.E., Mathew, B., L\u00e9on, J., G\u00f3mez Cano, F.A., Ballvora, A., and L\u00f3pez Carrascal, C.E. (2017). Major novel QTL for resistance to cassava bacterial blight identified through a multi-environmental analysis. Front. Plant Sci., 8.","DOI":"10.3389\/fpls.2017.01169"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00425-018-2863-4","article-title":"The overexpression of RXam1, a cassava gene coding for an RLK, confers disease resistance to Xanthomonas axonopodis pv. manihotis","volume":"247","author":"Verdier","year":"2018","journal-title":"Planta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11103-021-01211-2","article-title":"RXam2, a NLR from cassava (Manihot esculenta) contributes partially to the quantitative resistance to Xanthomonas phaseoli pv. manihotis","volume":"109","author":"Ochoa","year":"2022","journal-title":"Plant Mol. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41467-022-35675-7","article-title":"Improving cassava bacterial blight resistance by editing the epigenome","volume":"14","author":"Veley","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1093\/plphys\/kiae243","article-title":"CRISPR\/Cas9-generated mutations in a sugar transporter gene reduce cassava susceptibility to bacterial blight","volume":"195","author":"Elliott","year":"2024","journal-title":"Plant Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"42428","DOI":"10.1074\/jbc.R112.372300","article-title":"Structural basis for sirtuin activity and inhibition","volume":"287","author":"Yuan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3293","article-title":"Sirtuins as regulators of metabolism and healthspan","volume":"13","author":"Houtkooper","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Soccio, M., Laus, M.N., Alfarano, M., and Pastore, D. (2018). Measuring activity of native plant sirtuins\u2014The wheat mitochondrial model. Front. Plant Sci., 9.","DOI":"10.3389\/fpls.2018.00961"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1093\/nar\/gkf660","article-title":"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes","volume":"30","author":"Pandey","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhong, X., Zhang, H., Zhao, Y., Sun, Q., Hu, Y., Peng, H., and Zhou, D.X. (2013). The rice NAD(+)-dependent histone deacetylase OsSRT1 targets preferentially to stress- and metabolism-related genes and transposable elements. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066807"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhao, L., Lu, J., Zhang, J., Wu, P.Y., Yang, S., and Wu, K. (2015). Identification and characterization of histone deacetylases in tomato (Solanum lycopersicum). Front. Plant Sci., 5.","DOI":"10.3389\/fpls.2014.00760"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"136199","DOI":"10.1016\/j.ijbiomac.2024.136199","article-title":"The new function of FaSRT2-1 protein in energy metabolism: Promoting strawberry fruit quality and ripening","volume":"281","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.molp.2017.10.010","article-title":"Histone deacetylase AtSRT1 links metabolic flux and stress response in Arabidopsis","volume":"10","author":"Liu","year":"2017","journal-title":"Mol. Plant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.1093\/nar\/gkx825","article-title":"Rice NAD+-dependent histone deacetylase OsSRT1 represses glycolysis and regulates the moonlighting function of GAPDH as a transcriptional activator of glycolytic genes","volume":"45","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/nph.18060","article-title":"Histone deacetylase AtSRT2 regulates salt tolerance during seed germination via repression of vesicle-associated membrane protein 714 (VAMP714) in Arabidopsis","volume":"234","author":"Tang","year":"2022","journal-title":"N. Phytol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1111\/pce.14885","article-title":"A histone deacetylase, FaSRT1-2, plays multiple roles in regulating fruit ripening, plant growth and stresses resistance of cultivated strawberry","volume":"47","author":"Wang","year":"2024","journal-title":"Plant Cell Environ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/pbi.14174","article-title":"Ustilaginoidea virens-secreted effector Uv1809 suppresses rice immunity by enhancing OsSRT2-mediated histone deacetylation","volume":"22","author":"Chen","year":"2024","journal-title":"Plant Biotechnol. J."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhang, N., Liu, L., Li, S., Wei, Y., Ren, W., Li, M., Zhao, S., Sun, Z., Yang, X., and Ren, Y. (2025). TaHSP18.6 and TaSRT1 interact to confer resistance to Fusarium crown rot by regulating the auxin content in common wheat. Proc. Natl. Acad. Sci. USA, 122, Correction in Proc. Natl. Acad. Sci. USA\u00a02025, 122, e2530128122.","DOI":"10.1073\/pnas.2500029122"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pbi.2018.05.015","article-title":"NUCLEAR FACTOR-Y: Still complex after all these years?","volume":"45","author":"Myers","year":"2018","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tan, X., Zhang, H., Yang, Z., Wei, Z., Li, Y., Chen, J., and Sun, Z. (2022). NF-YA transcription factors suppress jasmonic acid-mediated antiviral defense and facilitate viral infection in rice. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010548"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Jiang, S., Wang, H., Wen, Y., Liang, J., Li, D., and Song, F. (2022). The NF-Y Transcription Factor Family in Watermelon: Re-Characterization, Assembly of ClNF-Y Complexes, Hormone and Pathogen-Inducible Expression and Putative Functions in Disease Resistance. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415778"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e70106","DOI":"10.1111\/tpj.70106","article-title":"StNF-YA8-YB20-YC5 module regulates potato tuber dormancy by modulating gibberellin and abscisic acid pathways","volume":"121","author":"Wang","year":"2025","journal-title":"Plant J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00299-021-02791-5","article-title":"Crosstalk among plant growth regulators and signaling molecules during biotic and abiotic stresses: Molecular responses and signaling pathways","volume":"40","author":"Aftab","year":"2021","journal-title":"Plant Cell Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/mp\/ssu050","article-title":"Connecting growth and defense: The emerging roles of brassinosteroids and gibberellins in plant innate immunity","volume":"7","year":"2014","journal-title":"Mol. Plant"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/tpj.16855","article-title":"A multifaceted crosstalk between brassinosteroid and gibberellin regulates the resistance of cucumber to Phytophthora melonis","volume":"119","author":"Kang","year":"2024","journal-title":"Plant J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tplants.2015.07.005","article-title":"Histone acetylation enzymes coordinate metabolism and gene expression","volume":"20","author":"Shen","year":"2015","journal-title":"Trends Plant Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101530","DOI":"10.1016\/j.xplc.2025.101530","article-title":"Nuclear factor-Y transcription factors in crops: Biological roles, regulation, and breeding applications","volume":"6","author":"Wu","year":"2025","journal-title":"Plant Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109154","DOI":"10.1016\/j.plaphy.2024.109154","article-title":"Overexpression of the Poa pratensis GA2ox gene family significantly reduced the plant height of transgenic Arabidopsis thaliana and Poa pratensis","volume":"216","author":"Su","year":"2024","journal-title":"Plant Physiol. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e70101","DOI":"10.1111\/ppl.70101","article-title":"GAI1 underlines the antagonism between gibberellin and jasmonic acid in modulating disease resistance","volume":"177","author":"Xu","year":"2025","journal-title":"Physiol. Plant."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"110434","DOI":"10.1016\/j.plantsci.2020.110434","article-title":"Review: The plant sirtuins","volume":"293","author":"Zheng","year":"2020","journal-title":"Plant Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.gde.2014.05.005","article-title":"Sirtuins, metabolism, and DNA repair","volume":"26","author":"Choi","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hu, H., He, L., Chen, R., Jing, Z., Wan, H., Xiao, Z., Cheng, H., Wu, C., and Liu, X. (2026). Genome-wide identification and multi-dimensional functional characterization of the SIR2 family in Brassica napus L.. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0340688"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1105\/tpc.17.00671","article-title":"Histone deacetylases SRT1 and SRT2 interact with ENAP1 to mediate ethylene-induced transcriptional repression","volume":"30","author":"Zhang","year":"2018","journal-title":"Plant Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15895","DOI":"10.1021\/acs.jafc.3c03560","article-title":"Important factors controlling gibberellin homeostasis in plant height regulation","volume":"71","author":"Zhou","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/csc2.20825","article-title":"DELLAs directed gibberellins responses orchestrate crop development: A brief review","volume":"63","author":"Sarwar","year":"2023","journal-title":"Crop Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1094\/MPMI-05-12-0138-R","article-title":"Gibberellin 20-oxidase gene OsGA20ox3 regulates plant stature and disease development in rice","volume":"26","author":"Qin","year":"2013","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, P., Guo, L., Lang, X., Li, M., Wu, G., Wu, R., Wang, L., Zhao, M., and Qing, L. (2022). Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010217"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41467-022-28189-9","article-title":"Citrus Huanglongbing is a pathogen-triggered immune disease that can be mitigated with antioxidants and gibberellin","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"000278","DOI":"10.1099\/acmi.0.000278","article-title":"Antimicrobial properties of phytohormone (gibberellins) against phytopathogens and clinical pathogens","volume":"3","author":"Toner","year":"2021","journal-title":"Access Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110925","DOI":"10.1016\/j.plantsci.2021.110925","article-title":"PbSRT1 and PbSRT2 regulate pear growth and ripening yet displaying a species-specific regulation in comparison to other Rosaceae spp.","volume":"308","author":"Torres","year":"2021","journal-title":"Plant Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/pbi.13511","article-title":"Stacking disease resistance and mineral biofortification in cassava varieties to enhance yields and consumer health","volume":"19","author":"Narayanan","year":"2021","journal-title":"Plant Biotechnol. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1093\/molbev\/msy118","article-title":"Bootstrap and rogue identification tests for phylogenetic analyses","volume":"35","author":"Russo","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/treephys\/tpy053","article-title":"Functional characterization of WHY-WRKY75 transcriptional module in plant response to cassava bacterial blight","volume":"38","author":"Liu","year":"2018","journal-title":"Tree Physiol."},{"key":"ref_52","first-page":"215","article-title":"Screening and Evaluation of Reference Genes in Cassava unpon Infection by Xanthomonas phaseoli pv. manihotis","volume":"17","author":"Li","year":"2026","journal-title":"J. Trop. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13007-022-00906-x","article-title":"A comparison of ImageJ and machine learning based image analysis methods to measure cassava bacterial blight disease severity","volume":"18","author":"Elliott","year":"2022","journal-title":"Plant Methods"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1038\/s41467-021-24375-3","article-title":"Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation","volume":"12","author":"Sun","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_55","first-page":"173","article-title":"Yeast GAL4 two-hybrid system. A genetic system to identify proteins that interact with a target protein","volume":"63","author":"Zhu","year":"1997","journal-title":"Methods Mol. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nbt.3876","article-title":"Long time-lapse nanoscopy with spontaneously blinking membrane probes","volume":"35","author":"Takakura","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1523\/JNEUROSCI.3262-18.2019","article-title":"Rgma-Induced Neo1 Proteolysis Promotes Neural Tube Morphogenesis","volume":"39","author":"Brown","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e20135","DOI":"10.7717\/peerj.20135","article-title":"Effects of shading stress on endogenous hormone levels in Eleutherococcus giraldii: Hormonal dynamics and growth strategy analysis","volume":"13","author":"Huang","year":"2025","journal-title":"PeerJ"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/19\/2898\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:36:13Z","timestamp":1790224573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/15\/19\/2898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":61,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["plants15192898"],"URL":"https:\/\/doi.org\/10.3390\/plants15192898","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}