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Although redox regulation, coupling between reactive oxygen species (ROS) and Ca2+, and hormone-mediated feedback loops have been extensively characterized within individual kingdoms, a cross-kingdom framework linking these pathways through metabolite-mediated modulation is lacking. Here, a cross-kingdom compilation of evidence from plant, animal, and microbial systems is presented to examine how specific endogenous and microbe-derived metabolites and plant fructans modulate the fidelity of stress signaling networks. We propose a metabolite-guided signal fidelity hypothesis in which certain specialized metabolites act as molecular stabilizers in the response of organisms to stress. They buffer transient ROS bursts, limit variability in calcium signaling, and strengthen hormone-regulated feedback loops. Together, these functions preserve the signal-to-noise ratio of stress responses, independent of overt toxicity. These insights lay the groundwork for testable predictions and the development of translational strategies in agriculture, biotechnology, and medicine aimed at improving stress tolerance by stabilizing the flow of biological information.<\/jats:p>","DOI":"10.3390\/plants15192972","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:37Z","timestamp":1790694877000},"page":"2972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant Stress Signaling in a Cross-Kingdom Context: Metabolic Control of Redox and ROS-Ca2+-Hormone Interactomes"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-4023","authenticated-orcid":false,"given":"Mohamad","family":"Warda","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Atat\u00fcrk University, Erzurum 25240, Turkey"},{"name":"Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Bolat","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samet","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"\u00c7inar","sequence":"additional","affiliation":[{"name":"Daytam East Anatolian High Technology Application and Research Center (DAYTAM), Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-3343","authenticated-orcid":false,"given":"Asl\u0131han","family":"Atasever","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, \u00c7ay\u0131rl\u0131 Vocational School, Erzincan Binali Y\u0131ld\u0131r\u0131m University, Erzincan 24500, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"\u015eeng\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikret","family":"\u00c7elebi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Cinar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-2703","authenticated-orcid":false,"given":"Mahmut Sinan","family":"Taspinar","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology, Faculty of Agriculture, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra Y.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Institute for Health & Wellbeing Research, University of Bedfordshire, University Square, Luton LU1 3JU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-5590","authenticated-orcid":false,"given":"\u00c2ngelo","family":"de F\u00e1tima","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"},{"name":"Department of Organic Chemistry, Faculty of Science, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-9254","authenticated-orcid":false,"given":"Andreia C. S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Bot\u00e2nica, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8994-8273","authenticated-orcid":false,"given":"Luis F. M. 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M.","family":"Abd El-Aty","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt"},{"name":"Department of Medical Pharmacology, Medical Faculty, Atat\u00fcrk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12944-025-02563-0","article-title":"Lipid rafts: Novel therapeutic targets for metabolic, neu-rodegenerative, oncological, and cardiovascular diseases","volume":"24","author":"Warda","year":"2025","journal-title":"Lipids Health Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1111\/pce.14935","article-title":"Redox regulation of plant stress and development","volume":"47","author":"Angelovici","year":"2024","journal-title":"Plant Cell Environ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.sajb.2024.04.047","article-title":"Calcium (Ca2+) signaling in plants: A plant stress perspective","volume":"169","author":"Naz","year":"2024","journal-title":"S. 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