{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:11:28Z","timestamp":1787317888537,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The authors are grateful to the both Department of Chemistry in University of Mugla (Turkey) and University of Constantine 1 (Algeria) and University of Dicle (Turkey) for providing funds to perform the present research.","award":["The authors are grateful to the both Department of Chemistry in University of Mugla (Turkey) and University of Constantine 1 (Algeria) and University of Dicle (Turkey) for providing funds to perform the present research."],"award-info":[{"award-number":["The authors are grateful to the both Department of Chemistry in University of Mugla (Turkey) and University of Constantine 1 (Algeria) and University of Dicle (Turkey) for providing funds to perform the present research."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Hypochaeris laevigata var. hipponensis (Asteraceae) is an endemic plant from Algeria. In the current study, we analyzed for the first time its chemical composition, especially phenolic constituents of dichloromethane (DCM), ethyl acetate (EA), and n-butanol (BuOH) fractionsof the aerial parts of Hypochaeris laevigata var. hipponensis by liquid chromatography-mass spectrometry (LC-MS\/MS). The number of phenolic compounds detected in DCM, EA, and BuOH fractions were found to be 9, 20, and 15, respectively. More specifically, 12 phenolic acids were detected. Among them, quinic acid, chlorogenic acid, and caffeic acid were the most abundant ones. Meanwhile, only seven flavonoids were detected. Among them, rutin, apigetrin, and isoquercitrin were the major ones. We also determined the total phenolic and flavonoid contents, and fraction EA showed the highest values, followed by BuOH, and DCM fractions. Furthermore, the antioxidant action was dictated by five methods and the tested plant fractions demonstrated a noteworthy antioxidant action.<\/jats:p>","DOI":"10.3390\/plants9040514","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:01:39Z","timestamp":1587042099000},"page":"514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phenolic Compounds from An Algerian Endemic Species of Hypochaeris laevigata var. hipponensis and Investigation of Antioxidant Activities"],"prefix":"10.3390","volume":"9","author":[{"given":"Nabila","family":"Souilah","sequence":"first","affiliation":[{"name":"Laboratory of Optimization of Agricultural Production in Sub-Humid Zones (LOPAZS), Faculty of Science, University of Skikda, Skikda 21000, Algeria"},{"name":"Laboratory of Valorization of Natural Resources, Bioactive Molecules and Physicochemical and Biological Analyzes Department of Chemistry, Faculty of Exact Sciences, University of Constantine 1, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1704-5515","authenticated-orcid":false,"given":"Zain","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Mu\u011fla Sitki Ko\u00e7man, Mu\u011fla 48000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences and Life, Faculty of Science, University of M\u2019sila, M\u2019sila 28000, Algeria"},{"name":"Laboratoire d\u2019ethnobotanique et des substances naturelles, D\u00e9partement des sciences naturelles, Ecole Normale Sup\u00e9rieure (ENS), Kouba, BP 92 Kouba, Algiers 16308, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-6316","authenticated-orcid":false,"given":"Kamel","family":"Medjroubi","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization of Natural Resources, Bioactive Molecules and Physicochemical and Biological Analyzes Department of Chemistry, Faculty of Exact Sciences, University of Constantine 1, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahar","family":"Hazmoune","sequence":"additional","affiliation":[{"name":"Laboratory of Optimization of Agricultural Production in Sub-Humid Zones (LOPAZS), Faculty of Science, University of Skikda, Skikda 21000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-5453","authenticated-orcid":false,"given":"Tarek","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences and Life, Faculty of Science, University of Badji Mokhtar, Annaba 23000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-4535","authenticated-orcid":false,"given":"Mehmet","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Mu\u011fla Sitki Ko\u00e7man, Mu\u011fla 48000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-2899","authenticated-orcid":false,"given":"Gema","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Espinardo, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-5673","authenticated-orcid":false,"given":"Salah","family":"Akkal","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization of Natural Resources, Bioactive Molecules and Physicochemical and Biological Analyzes Department of Chemistry, Faculty of Exact Sciences, University of Constantine 1, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"ref_1","unstructured":"Hamel, T. 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