{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:12:20Z","timestamp":1790784740512,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University","doi-asserted-by":"publisher","award":["RG-19-166-41"],"award-info":[{"award-number":["RG-19-166-41"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Phytochemical study of Chiliadenus montanus aerial parts afforded six compounds; Intermedeol (1), 5\u03b1-hydroperoxy-\u03b2-eudesmol (2), 5,7-dihydroxy-3,3\u2019,4\u2019-trimethoxyflavone (3), 5,7,4\u2019-trihydroxy-3,6,3\u2019-trimethoxyflavone (jaceidin) (4), eudesm-11,13-ene-1\u03b2,4\u03b2,7\u03b1-triol (5) and 1\u03b2,4\u03b2,7\u03b2,11-tetrahydroxyeudesmane (6). These compounds were identified based on their NMR spectral data. The isolated compounds were tested for their cytotoxicity against liver cancer cell line (HepG2) and breast cancer cell line (MCF-7). Jaceidin flavonoid (4) exhibited the highest cytotoxic effect in vitro. Therefore, both of jaceidin and C. montanus extract were evaluated for their in vivo anti-tumor activity against Ehrlich\u2019s ascites carcinoma (EAC). Compared to control group, jaceidin and C. montanus extract decreased the tumor weight, improved the histological picture of tumor cells, lowered the levels of VEGF and ameliorate the oxidative stress. Molecular docking and in silico studies suggested that jaceidin was a selective inhibitor of VEGF-mediated angiogenesis with excellent membrane permeability and oral bioavailability.<\/jats:p>","DOI":"10.3390\/plants9081031","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T08:28:35Z","timestamp":1597393715000},"page":"1031","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-0581","authenticated-orcid":false,"given":"Sameh S.","family":"Elhady","sequence":"first","affiliation":[{"name":"Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-4285","authenticated-orcid":false,"given":"Enas E.","family":"Eltamany","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amera E.","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A.","family":"Bagalagel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra A.","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhan M.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seif N.","family":"Ayyad","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science, Damietta University, New Damietta 34511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A. M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cytology &amp; Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Elgawish","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safwat A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abotaleb, M., Samuel, S.M., Varghese, E., Varghese, S., Kubatka, P., Liskova, A., and B\u00fcsselberg, D. (2019). 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