{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T01:56:33Z","timestamp":1775354193956,"version":"3.50.1"},"reference-count":91,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["492030"],"award-info":[{"award-number":["492030"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Mexico has a great diversity of cacti, however, many of their fruits have not been studied in greater depth. Several bioactive compounds available in cacti juices extract have demonstrated nutraceutical properties. Two cactus species are interesting for their biologically active pigments, which are chico (Pachycereus weberi (J. M. Coult.) Backeb)) and jiotilla (Escontria chiotilla (Weber) Rose)). Hence, the goal of this work was to evaluate the bioactive compounds, i.e., betalains, total phenolic, vitamin C, antioxidant, and mineral content in the extract of the above-mentioned P. weberi and E. chiotilla. Then, clarified extracts were evaluated for their antioxidant activity and cytotoxicity (cancer cell lines) potentialities. Based on the obtained results, Chico fruit extract was found to be a good source of vitamin C (27.19 \u00b1 1.95 mg L-Ascorbic acid\/100 g fresh sample). Moreover, chico extract resulted in a high concentration of micronutrients, i.e., potassium (517.75 \u00b1 16.78 mg\/100 g) and zinc (2.46 \u00b1 0.65 mg\/100 g). On the other hand, Jiotilla has a high content of biologically active pigment, i.e., betaxanthins (4.17 \u00b1 0.35 mg\/g dry sample). The antioxidant activities of clarified extracts of chico and jiotilla were 80.01 \u00b1 5.10 and 280.88 \u00b1 7.62 mg\/100 g fresh sample (DPPH method), respectively. From the cytotoxicity perspective against cancer cell lines, i.e., CaCo-2, MCF-7, HepG2, and PC-3, the clarified extracts of chico showed cytotoxicity (%cell viability) in CaCo-2 (49.7 \u00b1 0.01%) and MCF-7 (45.56 \u00b1 0.05%). A normal fibroblast cell line (NIH\/3T3) was used, as a control, for comparison purposes. While jiotilla extract had cytotoxicity against HepG2 (47.31 \u00b1 0.03%) and PC-3 (53.65 \u00b1 0.04%). These results demonstrated that Chico and jiotilla are excellent resources of biologically active constituents with nutraceuticals potentialities.<\/jats:p>","DOI":"10.3390\/plants9111623","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T11:50:34Z","timestamp":1606132234000},"page":"1623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Functional Attributes and Anticancer Potentialities of Chico (Pachycereus Weberi) and Jiotilla (Escontria Chiotilla) Fruits Extract"],"prefix":"10.3390","volume":"9","author":[{"given":"Luisaldo","family":"Sandate-Flores","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Romero-Esquivel","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Rostro-Alanis","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elda M.","family":"Melchor-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-4379","authenticated-orcid":false,"given":"Carlos","family":"Castillo-Zacar\u00edas","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Reyna","family":"Ontiveros","sequence":"additional","affiliation":[{"name":"Universidad Iberoamericana, Puebla, Avenida Tres Oriente, 615, 6, Centro, Puebla C.P. 72000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Fredy Morales","family":"Celaya","sequence":"additional","affiliation":[{"name":"Universidad Tecnol\u00f3gica de los Valles Centrales de Oaxaca, Oaxaca 71270, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-5076","authenticated-orcid":false,"given":"Wei-Ning","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-2720","authenticated-orcid":false,"given":"Hafiz M. N.","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Parra-Sald\u00edvar","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Biotecnolog\u00eda FEMSA, Avenida Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,22]]},"reference":[{"key":"ref_1","unstructured":"Guzm\u00e1n, U., Arias, S., and D\u00e1vila, P. (2003). Cat\u00e1logo de Cact\u00e1ceas Mexicanas, UNAM CONABIO. [1st ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.3390\/nu5104145","article-title":"Antioxidant and anticlastogenic capacity of prickly pear juice","volume":"5","year":"2013","journal-title":"Nutrients"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ponce, H.A., Mart\u00ednez-Salda\u00f1a, M.C., Rinc\u00f3n-S\u00e1nchez, A.R., Sumaya-Mart\u00ednez, M.T., Buist-Homan, M., Faber, K.N., Moshage, H., and Jaramillo-Ju\u00e1rez, F. (2016). Hepatoprotective effect of Opuntia robusta and Opuntia streptacantha fruits against acetaminophen-induced acute liver damage. Nutrients, 8.","DOI":"10.3390\/nu8100607"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.lwt.2018.01.078","article-title":"Effect of refrigerated storage on betacyanin composition, antibacterial activity of red pitahaya (Hylocereus polyrhizus) and cytotoxicity evaluation of betacyanin rich extract on normal human cell lines","volume":"91","author":"Yong","year":"2018","journal-title":"LWT Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/antiox2020037","article-title":"Comparative study of antioxidant power, polyphenols, flavonoids and betacyanins of the peel and pulp of three Tunisian Opuntia forms","volume":"2","author":"Yeddes","year":"2013","journal-title":"Antioxidants"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/antiox4020269","article-title":"Betalains, phenols and antioxidant capacity in cactus pear [Opuntia ficus-indica(L.) Mill.] Fruits from apulia (South Italy) genotypes","volume":"4","author":"Albano","year":"2015","journal-title":"Antioxidants"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11130-009-0117-0","article-title":"Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices","volume":"64","year":"2009","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.foodres.2013.08.043","article-title":"Evaluation of Opuntia spp. derived products as antiproliferative agents in human colon cancer cell line (HT29)","volume":"54","author":"Serra","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jaridenv.2006.12.016","article-title":"Use, extraction rates and spatial availability of plant resources in the Tehuac\u00e1n-Cuicatl\u00e1n Valley, Mexico: The case of Santiago Quiotepec, Oaxaca","volume":"70","author":"Casas","year":"2007","journal-title":"J. Arid Environ."},{"key":"ref_10","first-page":"452","article-title":"Pollination biology of two columnar cacti in the tehuacan valley, central Mexico","volume":"84","author":"Casas","year":"1997","journal-title":"J. Trop. Ecol."},{"key":"ref_11","unstructured":"(2019, February 20). Llifle Encyclopedias of Living Forms The Encyclopedia of Cacti. Available online: http:\/\/www.llifle.com\/Encyclopedia\/CACTI\/Family\/Cactaceae\/7669\/Pachycereus_weberi."},{"key":"ref_12","first-page":"1","article-title":"Use of columnar cacti in the Tehuac\u00e1n Valley, Mexico: Perspectives for sustainable management of non-timber forest products","volume":"10","author":"Casas","year":"2014","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1051\/fruits\/2015013","article-title":"Escontria chiotilla (Cactaceae): Fruit development, maturation and harvest index","volume":"70","year":"2015","journal-title":"Fruits"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-4269-9-38","article-title":"Influence of traditional markets on plant management in the Tehuac\u00e1n Valley Influence of traditional markets on plant management in the Tehuac\u00e1n Valley","volume":"9","author":"Arellanes","year":"2013","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1023\/A:1023902704131","article-title":"Morphological variation and domestication of Escontria chiotilla (Cactaceae) under silvicultural management in the Tehuac\u00e1n Valley, Central Mexico","volume":"50","author":"Arellano","year":"2003","journal-title":"Genet. Resour. Crop Evol."},{"key":"ref_16","first-page":"19","article-title":"A partial characterization of the red pigment from the Mexican fruit cactus \u201cjiotilla","volume":"6","year":"2007","journal-title":"\u201d Rev. Mex. Ing. Qu\u00edmica"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.foodchem.2018.08.069","article-title":"Spray drying microencapsulation of betalain rich extracts from Escontria chiotilla and Stenocereus queretaroensis fruits using cactus mucilage","volume":"272","year":"2019","journal-title":"Food Chem."},{"key":"ref_18","unstructured":"(2019, August 28). WHO Cancer. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer."},{"key":"ref_19","first-page":"1","article-title":"Effect of location on some physico-chemical properties of prickly pear (Opuntia ficus-indica L.) fruit and seeds","volume":"43","author":"Ghafoor","year":"2019","journal-title":"J. Food Process. Preserv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/jac.12353","article-title":"Nutritional and mineral content of prickly pear cactus: A highly water-use efficient forage, fodder and food species","volume":"205","author":"Mayer","year":"2019","journal-title":"J. Agron. Crop Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jcs.2012.08.017","article-title":"In vitro dephytinization and bioavailability of essential minerals in several wheat varieties","volume":"56","author":"Akhter","year":"2012","journal-title":"J. Cereal Sci."},{"key":"ref_22","unstructured":"Darnton-Hill, I. (2019, May 25). Zinc Supplementation and Growth in Children. Available online: https:\/\/www.who.int\/elena\/bbc\/zinc_stunting\/en\/."},{"key":"ref_23","unstructured":"World Health Organization (2019, August 19). Joint Child Malnutrition Estimates. Available online: http:\/\/apps.who.int\/gho\/tableau-public\/tpc-frame.jsp?id=402."},{"key":"ref_24","unstructured":"(2019, August 15). NIH Zinc Fact Sheet for Health Professionals, Available online: https:\/\/ods.od.nih.gov\/factsheets\/Zinc-HealthProfessional\/."},{"key":"ref_25","unstructured":"(2019, August 18). WHO Zinc Supplementation to Improve Treatment Outcomes among Children Diagnosed with Respiratory Infections. Available online: https:\/\/www.who.int\/elena\/titles\/bbc\/zinc_pneumonia_children\/en\/."},{"key":"ref_26","unstructured":"(2019, August 05). OECD Measuring Well-Being in Mexican States. Available online: http:\/\/www.oecd.org\/cfe\/regional-policy\/Mexican-States-Highlights-English.pdf."},{"key":"ref_27","unstructured":"Association of Official Agricultural Chemists (1990). AOAC Moisture Gravimetric Method. AOAC Official Method 934.06, AOAC International."},{"key":"ref_28","unstructured":"Association of Official Agricultural Chemists (1998). AOAC Official Methods of Analysis of AOAC International, Association of Official Analytical Chemists."},{"key":"ref_29","first-page":"20","article-title":"Evaluation of different methods for betanin quantification in pitaya (Stenocereus spp.)","volume":"27","year":"2016","journal-title":"Agro Food Ind. Hi Tech"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00217-002-0657-0","article-title":"Evaluation of colour properties and chemical quality parameters of cactus juices","volume":"216","author":"Stintzing","year":"2003","journal-title":"Eur. Food Res. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chroma.2012.04.067","article-title":"Sequential determination of fat- and water-soluble vitamins in green leafy vegetables during storage","volume":"1261","author":"Santos","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1021\/jf1005935","article-title":"A thorough study of reactivity of various compound classes towards the Folin-Ciocalteu","volume":"58","author":"Everette","year":"2010","journal-title":"J Agric Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: The FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Cuvelier","year":"1995","journal-title":"LWT Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100673","DOI":"10.1016\/j.fbio.2020.100673","article-title":"Metabolite profiling of three Opuntia ficus-indica fruit cultivars using UPLC-QTOF-MS in relation to their antioxidant potential","volume":"36","author":"Farag","year":"2020","journal-title":"Food Biosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.sajb.2020.03.005","article-title":"Structural elucidation of phenolic compounds isolated from Opuntia littoralis and their antidiabetic, antimicrobial and cytotoxic activity","volume":"131","author":"Sorour","year":"2020","journal-title":"South Afr. J. Bot."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11130-013-0391-8","article-title":"Physical, chemical, and antioxidant activity characterization of pitaya (Stenocereus pruinosus) fruits","volume":"68","year":"2013","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_40","first-page":"485","article-title":"Physicochemical, nutritional, and functional characterization of fruits xoconostle (Opuntia matudae) pears from central-M\u00e9xico Region","volume":"75","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_41","first-page":"15","article-title":"Nutrient analysis of some selected wild edible fruits of deciduous forests of India: An explorative study towards non conventional bio-nutrition","volume":"4","author":"Mahapatra","year":"2012","journal-title":"Adv. J. Food Sci. Technol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heliyon.2019.e01874","article-title":"Chemical ingredients and antioxidant activities of underutilized wild fruits","volume":"5","author":"Hegazy","year":"2019","journal-title":"Heliyon"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/jf0502698","article-title":"Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements","volume":"53","author":"Prior","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jfca.2015.01.017","article-title":"Dietary fiber, phytochemical composition and antioxidant activity of Mexican commercial varieties of cactus pear","volume":"41","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/10942912.2015.1022259","article-title":"Comparative analysis of betalain content in Stenocereus Stellatus fruits and other cactus fruits using principal component analysis","volume":"19","year":"2016","journal-title":"Int. J. Food Prop."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00217-001-0478-6","article-title":"Betalain and phenolic compositions of four beetroot (Beta vulgaris) cultivars","volume":"214","author":"Kujala","year":"2002","journal-title":"Eur. Food Res. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0308-8146(01)00251-5","article-title":"An investigation of antioxidant capacity of fruits in Singapore markets","volume":"76","author":"Leong","year":"2002","journal-title":"Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Vissers, M.C.M., Carr, A.C., Pullar, J.M., and Bozonet, S.M. (2013). The Bioavailability of Vitamin C from Kiwifruit, Elsevier Inc.. [1st ed.].","DOI":"10.1016\/B978-0-12-394294-4.00007-9"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/jf60227a026","article-title":"Vitamin C contents of citrus fruit and their products: A Review","volume":"28","author":"Steven","year":"1980","journal-title":"J. Agric. Food Chem."},{"key":"ref_50","first-page":"398","article-title":"Sensory and physicochemical characterization of juices made with pomegranate and blueberries, blackberries, or raspberries","volume":"75","author":"Chambers","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1750-3841.2010.01571.x","article-title":"Phenolic content and antioxidant activity of raspberry and blackberry cultivars","volume":"75","author":"Sariburun","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodchem.2011.04.079","article-title":"Antioxidant capacities and total phenolic contents of 62 fruits","volume":"129","author":"Fu","year":"2011","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jfca.2007.10.002","article-title":"Changes of antioxidant activity and total phenolic compounds during storage of selected fruits","volume":"21","author":"Patthamakanokporn","year":"2008","journal-title":"J. Food Compos. Anal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfoodeng.2019.05.011","article-title":"Effect of different grape residues polyphenols impregnation techniques in mango","volume":"262","author":"Azoubel","year":"2019","journal-title":"J. Food Eng."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.nutres.2003.08.005","article-title":"Antioxidant activities of peel, pulp and seed fractions of common fruits as determined by FRAP assay","volume":"23","author":"Guo","year":"2003","journal-title":"Nutr. Res."},{"key":"ref_56","first-page":"257","article-title":"Functional composition and antioxidant activities of eight Moroccan date fruit varieties (Phoenix dactylifera L.)","volume":"16","author":"Ramchoun","year":"2017","journal-title":"J. Saudi Soc. Agric. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2621.2006.01347.x","article-title":"Antioxidant capacity of fresh, sun- and sulphited-dried Malatya apricot (Prunus armeniaca) assayed by CUPRAC, ABTS\/TEAC and folin methods","volume":"41","author":"Altun","year":"2006","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jff.2012.10.009","article-title":"Phytochemical properties and antioxidant capacities of commercial raspberry varieties","volume":"5","author":"Chen","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.microc.2019.103962","article-title":"The positive impact of a new parting process on antioxidant activity, malic acid and phenolic content of Prunus avium L., Prunus persica L. and Prunus domestica subsp. Insititia L. powders","volume":"149","author":"Mousavi","year":"2019","journal-title":"Microchem. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11130-019-00756-4","article-title":"Analysis of wild Raspberries (Rubus idaeus L): Optimization of the ultrasonic-assisted extraction of phenolics and a new insight in phenolics bioaccessibility","volume":"4","author":"Mihailovi","year":"2019","journal-title":"Plant Food Hum. Nutr."},{"key":"ref_61","unstructured":"(2019, May 05). USDA National Nutrient Database for Standard Reference Legacy Release, Available online: https:\/\/www.usda.gov\/."},{"key":"ref_62","first-page":"57","article-title":"Phytochemical characterization of prickly pear (Opuntia spp) and of its nutritional and functional properties: A Review","volume":"52","year":"2014","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_63","unstructured":"(2019, May 05). NIH National Institutes of Health Office of Dietary Supplements, Available online: https:\/\/ods.od.nih.gov\/factsheets\/Magnesium-HealthProfessional\/."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.foodchem.2005.02.003","article-title":"Mineral content of tropical fruits and unconventional foods of the Andes and the rain forest of Colombia","volume":"95","author":"Leterme","year":"2006","journal-title":"Food Chem."},{"key":"ref_65","first-page":"61","article-title":"Antioxidant activity, phenolic compounds and colour of red wines treated with new fining agents","volume":"57","author":"Dumitriu","year":"2018","journal-title":"Vitis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jfoodeng.2018.08.006","article-title":"Maximisation of the polyphenols extraction yield from green tea leaves and sequential clarification","volume":"241","author":"Menezes","year":"2019","journal-title":"J. Food Eng."},{"key":"ref_67","first-page":"1055","article-title":"Effect of clarification on the polyphenolic compound content and antioxidant activity of commercial apple juices","volume":"19","author":"Candrawinata","year":"2012","journal-title":"Int. Food Res. J."},{"key":"ref_68","first-page":"901","article-title":"Effects of Centrifugation, Encapsulation Method and Different Coating Materials on the Total Antioxidant Activity of the Microcapsules of Powdered Cherry Laurels","volume":"10","author":"Sumnu","year":"2016","journal-title":"World Acad. Sci. Eng. Technol. Int. J. Nutr. Food Eng."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/ijfs.13573","article-title":"Polyphenols, ascorbic acid and antioxidant capacity of commercial nutritional drinks, fruit juices, smoothies and teas","volume":"53","author":"Abountiolas","year":"2018","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jphotobiol.2017.05.031","article-title":"The impact of anticancer activity upon Beta vulgaris extract mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines","volume":"173","author":"Venugopal","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1021\/jf404648u","article-title":"Betalain and betaine composition of greenhouse- or field-produced beetroot (Beta vulgaris L.) and inhibition of HepG2 Cell proliferation","volume":"62","author":"Lee","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ponce, H.A., Rinc\u00f3n-S\u00e1nchez, A.R., Jaramillo-Ju\u00e1rez, F., and Moshage, H. (2018). Natural dietary pigments: Potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs. Nutrients, 10.","DOI":"10.3390\/nu10020117"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/187152011795347504","article-title":"Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the Human Prostate (PC-3) and breast (MCF-7) cancer cell lines","volume":"11","author":"Kapadia","year":"2012","journal-title":"Anticancer. Agents Med. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.toxrep.2015.08.002","article-title":"Protective effect of p-coumaric acid against doxorubicin induced toxicity in H9c2 cardiomyoblast cell lines","volume":"2","author":"Chacko","year":"2015","journal-title":"Toxicol. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/mnfr.200500014","article-title":"Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29","volume":"49","author":"Ferguson","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/jf00118a025","article-title":"Reaction of p-hydroxycinnamic acid derivatives with nitrite and its relevance to nitrosamine formation","volume":"1","author":"Kikugawa","year":"1983","journal-title":"J. Agric. Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1021\/jf050489l","article-title":"Differential effects of ferulic acid and p-coumaric acid on S phase distribution and length of S phase in the human colonic cell line Caco-2","volume":"53","author":"Janicke","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.3748\/wjg.v19.i43.7726","article-title":"Events associated with apoptotic effect of p -Coumaric acid in HCT-15 colon cancer cells","volume":"19","author":"Jaganathan","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10753-012-9532-8","article-title":"Immunomodulatory and anti- inflammatory effect of p-coumaric acid: A common dietary polyphenol on experimental inflammation in rats","volume":"36","author":"Pragasam","year":"2013","journal-title":"Inflammation"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mrgentox.2003.08.005","article-title":"Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls","volume":"542","author":"Ferguson","year":"2003","journal-title":"Mutat. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"66226","DOI":"10.18632\/oncotarget.19887","article-title":"Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death","volume":"8","author":"Muhammad","year":"2017","journal-title":"Oncotarget"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"33202","DOI":"10.18632\/oncotarget.8898","article-title":"Immunomodula- tory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth","volume":"7","author":"Bhattacharya","year":"2016","journal-title":"Oncotarget"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1021\/jf0207530","article-title":"Antioxidant and antiproliferative activities of common Fruits","volume":"50","author":"Sun","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0072748","article-title":"Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors","volume":"8","author":"De","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_85","first-page":"525","article-title":"Gallic acid Inhibits proliferation and induces apoptosis in lymphoblastic leukemia cell line","volume":"41","author":"Sourani","year":"2016","journal-title":"Iran. J. Med. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbi.2009.02.013","article-title":"Bioactive components of tea: Cancer, inflammation and behavior","volume":"23","author":"Puangpraphant","year":"2009","journal-title":"Brain. Behav. Immun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3892\/ol.2014.2818","article-title":"Selecting bioactive phe- nolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells","volume":"9","author":"He","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2174\/138955711796268750","article-title":"Caffeic acid, a versatile pharmacophore: An overview","volume":"11","author":"Touaibia","year":"2011","journal-title":"Mini-Reviews Med. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1039\/C3AY41807C","article-title":"Caffeic acid: A review of its potential use in medications and cosmetics","volume":"6","author":"Magnani","year":"2014","journal-title":"Anal. Methods"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-23714-7","article-title":"Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expressions","volume":"8","author":"Sant","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.foodchem.2017.04.174","article-title":"Betalains and phenolic compounds profiling and antioxidant capacity of pitaya (Stenocereus spp.) fruit from two species (S. Pruinosus and S. stellatus)","volume":"234","year":"2017","journal-title":"Food Chem."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/9\/11\/1623\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:35:43Z","timestamp":1760178943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/9\/11\/1623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,22]]},"references-count":91,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["plants9111623"],"URL":"https:\/\/doi.org\/10.3390\/plants9111623","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,22]]}}}