{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:05:55Z","timestamp":1782759955003,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>A new dihydroisocoumarin glucoside, vacillanoside (3), and two new anthrone C-glycosides microdantin derivatives; vacillantin A (10) and B (11), together with nine known compounds belonging to the anthraquinone, anthrone and isocoumarin groups were isolated from the leaves of Aloe vacillans. The structures were determined based on spectroscopic evidence including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and high resolution mass spectrometry (HRESIMS) data, along with comparisons to reported data. The leaves were used to extract compounds with different solvents. The extracts were tested for antioxidant activity with a variety of in vitro tests including 2,2-diphenyl-1-picrylhydrazyl (DPPH\u2022), 2,2\u2032-azino-bis (3-ethylbenzothiazoline-6-sulfonate (ABTS\u2022+), ferric reducing antioxidant power assay (FRAP), superoxide, and nitric oxide radical scavenging assays. The dichloromethane fraction was most active, displaying significant free radical scavenging activity. The n-butanol fraction also showed notable activity in all assays. Therefore, these findings support the potential use of A. vacillans leaves as an antioxidant medication due to the presence of polyphenolic compounds.<\/jats:p>","DOI":"10.3390\/plants9121632","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T09:06:28Z","timestamp":1606208788000},"page":"1632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vacillantins A and B, New Anthrone C-glycosides, and a New Dihydroisocoumarin Glucoside from Aloe vacillans and Its Antioxidant Activities"],"prefix":"10.3390","volume":"9","author":[{"given":"Maram","family":"Al-Tamimi","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, PO. Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-7205","authenticated-orcid":false,"given":"Shaza M.","family":"Al-Massarani","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, PO. Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"El-Gamal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, PO. Box 2457, Riyadh 11451, Saudi Arabia"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, El-Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer A.","family":"Basudan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, PO. Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-2656","authenticated-orcid":false,"given":"Maged S.","family":"Abdel-Kader","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, College of Pharmacy, Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia"},{"name":"Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-684X","authenticated-orcid":false,"given":"Wael M.","family":"Abdel-Mageed","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, PO. Box 2457, Riyadh 11451, Saudi Arabia"},{"name":"Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"ref_1","first-page":"74","article-title":"Botanical aspects of Aloes of North East Africa","volume":"10","author":"Demmisew","year":"1996","journal-title":"Bull. Chem. Soc. Ethiop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1080\/10408398.2018.1496320","article-title":"Biomedical applications of Aloe vera","volume":"59","author":"Gao","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/10408690490424694","article-title":"Aloe Vera: A Valuable Ingredient for the Food, Pharmaceutical and Cosmetic Industries\u2014A Review","volume":"44","author":"Kojo","year":"2004","journal-title":"Crit. Rev. 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