{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:08:09Z","timestamp":1769152089746,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Coronary Heart Disease (CHD) is one of the leading causes of death worldwide, claiming over seven million lives each year. Permanent metal stents, the current standard of care for CHD, inhibit arterial vasomotion and induce serious complications such as late stent thrombosis. Bioresorbable vascular scaffolds (BVSs) made from poly l-lactide (PLLA) overcome these complications by supporting the occluded artery for 3\u20136 months and then being completely resorbed in 2\u20133 years, leaving behind a healthy artery. The BVS that recently received clinical approval is, however, relatively thick (~150 \u00b5m, approximately twice as thick as metal stents ~80 \u00b5m). Thinner scaffolds would facilitate implantation and enable treatment of smaller arteries. The key to a thinner scaffold is careful control of the PLLA microstructure during processing to confer greater strength in a thinner profile. However, the rapid time scales of processing (~1 s) defy prediction due to a lack of structural information. Here, we present a custom-designed instrument that connects the strain-field imposed on PLLA during processing to in situ development of microstructure observed using synchrotron X-ray scattering. The connection between deformation, structure and strength enables processing\u2013structure\u2013property relationships to guide the design of thinner yet stronger BVSs.<\/jats:p>","DOI":"10.3390\/polym10030288","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T12:07:33Z","timestamp":1520510853000},"page":"288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition"],"prefix":"10.3390","volume":"10","author":[{"given":"Karthik","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-4182","authenticated-orcid":false,"given":"Riccardo","family":"Miscioscia","sequence":"additional","affiliation":[{"name":"Division of Sustainable Materials, ENEA, Centro Ricerche Portici, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Filippo","sequence":"additional","affiliation":[{"name":"Division of Photovoltaics and Smart Networks, Innovative Device Unit, Centro Ricerche Portici, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pandolfi","sequence":"additional","affiliation":[{"name":"Division of Sustainable Materials, ENEA, Centro Ricerche Portici, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Di Luccio","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"Division of Sustainable Materials, ENEA, Centro Ricerche Portici, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kornfield","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2010). 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