{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:20:34Z","timestamp":1776115234826,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8\u2013based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.<\/jats:p>","DOI":"10.3390\/polym10050476","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T06:52:23Z","timestamp":1524811943000},"page":"476","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3979-2362","authenticated-orcid":false,"given":"Jingyu","family":"Ran","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"},{"name":"School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Basic Medical Experimental Teaching Center, School of Basic Medical Science, Guizhou Medical University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyi","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[{"name":"The State Key Laboratories of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Co. Ltd., Tianjin 300193, China"},{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidang","family":"Wu","sequence":"additional","affiliation":[{"name":"The State Key Laboratories of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Co. Ltd., Tianjin 300193, China"},{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Guizhou Medical University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prasad, A.S. (1993). Biochemistry of Zinc, Plenum.","DOI":"10.1007\/978-1-4757-9444-1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/CEJ.0000000000000194","article-title":"Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer","volume":"25","author":"Hoang","year":"2016","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/MCO.0b013e32833106ee","article-title":"Zinc and prostatic cancer","volume":"12","author":"Song","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3945\/ajcn.110.004804","article-title":"Dietary zinc and prostate cancer survival in a Swedish cohort","volume":"93","author":"Epstein","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_5","first-page":"BC25","article-title":"Serum levels of metal ions in female patients with breast cancer","volume":"9","author":"Pavithra","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"A4","DOI":"10.1186\/1897-4287-10-S4-A4","article-title":"Selenium (Se) and breast cancer risk","volume":"10","author":"Jakubowska","year":"2012","journal-title":"Hered. Cancer Clin. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Costello, L.C., and Franklin, R.B. (2013). A review of the current status and concept of the emerging implications of zinc and zinc transporters in the development of pancreatic cancer. Pancreat. Disord. Ther.","DOI":"10.4172\/2165-7092.S4-002"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jnutbio.2009.12.001","article-title":"Increased level of exogenous zinc induces cytotoxicity and up-regulates the expression of the ZnT-1 zinc transporter gene in pancreatic cancer cells","volume":"22","author":"Jayaraman","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/jnci\/93.20.1525","article-title":"Esophageal cancer prevention in zinc-deficient rats: Rapid induction of apoptosis by replenishing zinc","volume":"93","author":"Fong","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.lfs.2009.10.006","article-title":"Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats","volume":"85","author":"Hamano","year":"2009","journal-title":"Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1021\/ar900116g","article-title":"Synthesis, structure, and carbon dioxide capture properties of zeolitic imidazolate frameworks","volume":"43","author":"Phan","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1038\/ncomms8240","article-title":"Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules","volume":"6","author":"Liang","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1002\/adma.201602335","article-title":"Metal\u2013organic framework coatings as cytoprotective exoskeletons for living cells","volume":"28","author":"Liang","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8510","DOI":"10.1002\/anie.201704120","article-title":"An Enzyme-Coated Metal\u2013Organic Framework Shell for Synthetically Adaptive Cell Survival","volume":"129","author":"Liang","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1702958","DOI":"10.1002\/smll.201702958","article-title":"Nano-Biohybrids: In Vivo Synthesis of Metal\u2013Organic Frameworks inside Living Plants","volume":"14","author":"Richardson","year":"2018","journal-title":"Small"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1002\/adma.201503167","article-title":"Biomimetic replication of microscopic metal\u2013organic framework patterns using printed protein patterns","volume":"27","author":"Liang","year":"2015","journal-title":"Adv. Mater"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/jacs.5b11720","article-title":"One-pot synthesis of metal\u2013organic frameworks with encapsulated target molecules and their applications for controlled drug delivery","volume":"138","author":"Zheng","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1039\/C6CC09680H","article-title":"Biomimetic mineralization of metal\u2013organic frameworks around polysaccharides","volume":"53","author":"Liang","year":"2017","journal-title":"Chem. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1021\/nl5026419","article-title":"One-pot synthesis of protein-embedded metal\u2013organic frameworks with enhanced biological activities","volume":"14","author":"Lyu","year":"2014","journal-title":"Nano Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1039\/C3CC47666A","article-title":"Polyacrylic acid@ zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release","volume":"50","author":"Ren","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"055604","DOI":"10.1088\/1361-6528\/28\/5\/055604","article-title":"Zeolitic imidazolate framework-8 (ZIF-8) as a sacrificial template: One-pot synthesis of hollow poly (dopamine) nanocapsules and yolk-structured poly (dopamine) nanocomposites","volume":"28","author":"Ran","year":"2016","journal-title":"Nanotechnology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9384","DOI":"10.1021\/nn404117j","article-title":"Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo","volume":"7","author":"Liu","year":"2013","journal-title":"ACS Nano"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11360","DOI":"10.1002\/anie.201101521","article-title":"Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles","volume":"50","author":"Ling","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.1039\/C6SC01320A","article-title":"Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-\/photothermal therapy","volume":"7","author":"Ding","year":"2016","journal-title":"Chem. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1039\/B916619J","article-title":"Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition","volume":"20","author":"Zhou","year":"2010","journal-title":"J. Mater. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1021\/cm400260g","article-title":"Surface and bulk integrations of single-layered Au or Ag nanoparticles onto designated crystal planes {110} or {100} of ZIF-8","volume":"25","author":"Li","year":"2013","journal-title":"Chem. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1039\/C5RA24336J","article-title":"Surface defection reduces cytotoxicity of Zn (2-methylimidazole) 2 (ZIF-8) without compromising its drug delivery capacity","volume":"6","author":"Shearier","year":"2016","journal-title":"RSC Adv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: Impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_29","first-page":"93","article-title":"Biomimetic synthesis of coordination network materials: Recent advances in MOFs and MPNs","volume":"10","author":"Chu","year":"2018","journal-title":"Mater. Today"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00432-010-0926-4","article-title":"Chemopreventive effects of zinc on prostate carcinogenesis induced by N-methyl-N-nitrosourea and testosterone in adult male Sprague-Dawley rats","volume":"137","author":"Banudevi","year":"2011","journal-title":"J. Cancer Res. Clin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ejmech.2016.10.041","article-title":"Synthesis of copper and zinc 2-(pyridin-2-yl) imidazo [1,2-a] pyridine complexes and their potential anticancer activity","volume":"126","author":"Dam","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/1440-1681.12681","article-title":"Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence","volume":"44","author":"Hassan","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1096\/fj.201700227RRR","article-title":"Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1","volume":"32","author":"Choi","year":"2018","journal-title":"FASEB J."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/10\/5\/476\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:02:22Z","timestamp":1760194942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/10\/5\/476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,27]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5]]}},"alternative-id":["polym10050476"],"URL":"https:\/\/doi.org\/10.3390\/polym10050476","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,27]]}}}