{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:01:47Z","timestamp":1768687307801,"version":"3.49.0"},"reference-count":67,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The use of biocompatible polymers such as Hydroxypropylmethylcellulose (HPMC), Hydroxyethylcellulose (HEC), Carboxymethylcellulose (CMC), and Carbopol in solid formulations results in mucoadhesive systems capable of promoting the prolonged and localized release of Active Pharmaceutical Ingredients (APIs). This strategy represents a technological innovation that can be applied to improving the treatment of oral infections, such as oral candidiasis. Therefore, the aim of this study was to develop a tablet of Ximenia americana L. from mucoadhesive polymers for use in the treatment of oral candidiasis. An X. americana extract (MIC of 125 \u03bcg\u00b7mL\u22121) was obtained by turbolysis at 50% of ethanol, a level that demonstrated activity against Candida albicans. Differential Thermal Analysis and Fourier Transform Infrared Spectroscopy techniques allowed the choice of HPMC as a mucoadhesive agent, besides polyvinylpyrrolidone, magnesium stearate, and mannitol to integrate the formulation of X. americana. These excipients were granulated with an ethanolic solution 70% v\/v at PVP 5%, and a mucoadhesive tablet was obtained by compression. Finally, mucoadhesive strength was evaluated, and the results demonstrated good mucoadhesive forces in mucin disk and pig buccal mucosa. Therefore, the study allowed a new alternative to be developed for the treatment of buccal candidiasis, one which overcomes the inconveniences of common treatments, costs little, and facilitates patients\u2019 adhesion.<\/jats:p>","DOI":"10.3390\/polym11020379","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T11:45:39Z","timestamp":1550663139000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections"],"prefix":"10.3390","volume":"11","author":[{"given":"Lucas","family":"Almeida","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7247-1598","authenticated-orcid":false,"given":"Jo\u00e3o Augusto","family":"Oshiro J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Widson","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Centro de Tecnologia e Desenvolvimento Regional, Universidade Federal da Para\u00edba, Av. dos Escoteiros, s\/n, Mangabeira VII, 58055-000, Jo\u00e3o Pessoa, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-3778","authenticated-orcid":false,"given":"Germano","family":"Veras","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Anal\u00edtica e Quimiometria, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. Bara\u00fanas, 351, Cidade Universit\u00e1ria, 58429-500, Campina Grande, Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cl\u00e1udia","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual da Para\u00edba, R. 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