{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:59:26Z","timestamp":1768485566031,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["0020205401186"],"award-info":[{"award-number":["0020205401186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Many studies about fabricating organic-inorganic composite materials have been carried out in order to mimic the natural structure of bone. Pearl, which has a special block-and-mortar hierarchical structure, is a superior bone repair material with high osteogenic activity, but it shows few applications in the clinical bone repair and reconstruction because of its brittle and uneasily shaped properties. In this work, pearl powder (P)\/poly (amino acid) (PAA) composites were successfully prepared by a method of in situ melting polycondensation to combine the high osteogenic activity of the pearl and the pliability of the PAA. The mechanical properties, in vitro bioactivity and biocompatibility as well as osteogenic activity of the composites were investigated. The results showed that P\/PAA composites have both good mechanical properties and bioactivity. The compressive strength, bending strength and tensile strength of the composites reached a maximum of 161 MPa, 50 MPa and 42 MPa, respectively; in addition, apatite particles successfully deposited on the composites surface after immersion in simulated body fluid (SBF) for 7 days indicated that P\/PAA composites showed an enhanced mineralization capacity and bioactivity due to incorporation of pearl powder and PAA. The cell culture results revealed that higher cell proliferation and better adhesion morphology of mouse bone marrow mesenchymal stem cells (MSCs) appeared on the composite surface. Moreover, cells growing on the surface of the composites exhibited higher alkaline phosphatase (ALP) activity, more calcium nodule-formation, and higher expression levels of osteogenic differentiation-related genes (COL 1, RunX2, OCN, and OPN) than cells grown on PAA surface. The P\/PAA composites exhibited both superior mechanical properties to the pearl powder, higher bioactivity and osteogenic capability compared with those of PAA.<\/jats:p>","DOI":"10.3390\/polym11050831","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:22:35Z","timestamp":1557400955000},"page":"831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Preparation, Characterization and In Vitro Biological Evaluation of a Novel Pearl Powder\/Poly-Amino Acid Composite as a Potential Substitute for Bone Repair and Reconstruction"],"prefix":"10.3390","volume":"11","author":[{"given":"Yanan","family":"Wu","sequence":"first","affiliation":[{"name":"College of Physical Science and Technology, Sichuan University, Chengdu 610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwen","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Physical Science and Technology, Sichuan University, Chengdu 610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haohao","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Physical Science and Technology, Sichuan University, Chengdu 610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizhi","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Physical Science and Technology, Sichuan University, Chengdu 610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Physical Science and Technology, Sichuan University, Chengdu 610064, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nmat1866","article-title":"Living with cracks: Damage and repair in human bone","volume":"6","author":"Taylor","year":"2007","journal-title":"Nat. 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