{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:19:59Z","timestamp":1784128799828,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Provincial Natural Science Foundation, China","award":["ZR2018MEM024"],"award-info":[{"award-number":["ZR2018MEM024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>To improve the hemocompatibility of the biodegradable medical poly(ether-ester-urethane) (PEEU), containing uniform-size aliphatic hard segments that was prepared in our lab, a copolymer containing phosphorylcholine (PC) groups was blended with the PEEU. The PC-copolymer of poly(MPC-co-EHMA) (PMEH) was first obtained by copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 2-ethylhexyl methacrylate (EHMA), and then dissolved in mixed solvent of ethanol\/chloroform to obtain a homogeneous solution. The composite films (PMPU) with varying PMEH content were prepared by solvent evaporation method. The physicochemical properties of the composite films with varying PMEH content were researched. The PMPU films exhibited higher thermal stability than that of the pure PEEU film. With the PMEH content increasing from 5 to 20 wt%, the PMPU films also possessed satisfied tensile properties with ultimate stress of 22.9\u201315.8 MPa and strain at break of 925\u2013820%. The surface and bulk hydrophilicity of the films were improved after incorporation of PMEH. In vitro degradation studies indicated that the degradation rate increased with PMEH content, and it took 12\u201324 days for composite films to become fragments. The protein adsorption and platelet-rich plasma contact tests were adapted to evaluate the surface hemocompatibility of the composite films. It was found that the amount of adsorbed protein and adherent platelet on the surface decreased significantly, and almost no activated platelets were observed when PMEH content was above 5 wt%, which manifested good surface hemocompatibility. Due to the biodegradability, acceptable tensile properties and good surface hemocompatibility, the composites can be expected to be applied in blood-contacting implant materials.<\/jats:p>","DOI":"10.3390\/polym11050860","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:35:39Z","timestamp":1557725739000},"page":"860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preparation, Physicochemical Properties, and Hemocompatibility of the Composites Based on Biodegradable Poly(Ether-Ester-Urethane) and Phosphorylcholine-Containing Copolymer"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-761X","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Public Security Management Technology in Universities of Shandong, Shandong Management University, Jinan 250357, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jia","sequence":"additional","affiliation":[{"name":"Qilu Pharmaceutical Co. Ltd., Jinan 250104, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-5648","authenticated-orcid":false,"given":"Zhaosheng","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Heath, D.E., and Cooper, S.L. (2013). Polyurethanes, Elsevier.","DOI":"10.1016\/B978-0-08-087780-8.00009-7"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11706-009-0013-4","article-title":"Synthesis and characterization of biodegradable polyurethane based on poly(\u03b5-caprolactone) and L-lysine ethyl ester diisocyanate","volume":"3","author":"Han","year":"2009","journal-title":"Front. Mater. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Xu, W., Xiao, M., Yuan, L., Zhang, J., and Hou, Z. (2018). Preparation, physicochemical properties and hemo-compatibility of biodegradable chitooligosaccharide-based polyurethane. Polymers, 10.","DOI":"10.3390\/polym10060580"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s12013-013-9528-5","article-title":"The preparation and performance of a new polyurethane vascular prosthesis","volume":"66","author":"He","year":"2013","journal-title":"Cell. Biochem. Biophys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/0885328212468184","article-title":"Surface modification of polyurethane towards promoting the ex vivo cytocompatibility and in vivo biocompatibility for hypopharyngeal tissue engineering","volume":"28","author":"Shen","year":"2012","journal-title":"J. Biomater. Appl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/bm010044f","article-title":"In vitro studies on the effect of physical cross-linking on the biological performance of aliphatic poly(urethane urea) for blood contact applications","volume":"2","author":"Thomas","year":"2001","journal-title":"Biomacromolecules"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/jbm.b.33081","article-title":"Biomimetic myocardial patches fabricated with poly(\u025b-caprolactone) and polyethylene glycol-based polyurethanes","volume":"102","author":"Silvestri","year":"2014","journal-title":"J. Biomed. Mater. Res. B"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/teb.2007.0133","article-title":"Biodegradable polyurethanes: Synthesis and applications in regenerative medicine","volume":"14","author":"Guelcher","year":"2008","journal-title":"Tissue Eng. B"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/jbm.820251206","article-title":"Water-curable and biodegradable prepolymers","volume":"25","author":"Kobayashi","year":"1991","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0142-9612(03)00476-9","article-title":"Biodegradable poly(ether ester urethane) urea elastomers based on poly(ether ester) triblock copolymers and putrescine: synthesis, characterization and cytocompatibility","volume":"25","author":"Guan","year":"2004","journal-title":"Biomaterials"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002890050366","article-title":"On the role of aminolysis and transesterification in the synthesis of \u025b-caprolactone and L-lactide based polyurethanes","volume":"41","author":"Groot","year":"1998","journal-title":"Polym. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s002890050343","article-title":"High molecular weight polyurethanes and a polyurethane urea based on 1,4-butanediisocyanate","volume":"41","author":"Spaans","year":"1998","journal-title":"Polym. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cclet.2015.07.018","article-title":"Synthesis and characterization of a new biodegradable polyurethanes with good mechanical properties","volume":"27","author":"Qu","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/00914037.2016.1233416","article-title":"Influence of well-defined hard segment length on the properties of medical segmented polyesterurethanes based on poly(\u03b5-caprolactone-co-L-lactide) and aliphatic urethane diisocyanates","volume":"66","author":"Jia","year":"2017","journal-title":"Int. J. Polym. Mater. Po."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1021\/acs.chemmater.5b02086","article-title":"Super stretchable electroactive elastomer formation driven by aniline trimer self-assembly","volume":"27","author":"Chen","year":"2015","journal-title":"Chem. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1038\/s41467-018-04998-9","article-title":"Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1900046","DOI":"10.1002\/smll.201900046","article-title":"Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing","volume":"15","author":"Liang","year":"2019","journal-title":"Small"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biomaterials.2018.08.044","article-title":"Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing","volume":"183","author":"Qu","year":"2018","journal-title":"Biomaterials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.actbio.2009.03.001","article-title":"Lysine-PEG-modified polyurethane as a fibrinolytic surface: Effect of PEG chain length on protein interactions, platelet interactions and clot lysis","volume":"5","author":"Li","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10856-016-5694-5","article-title":"Tissue adhesives for meniscus tear repair: An overview of current advances and prospects for future clinical solutions","volume":"27","author":"Bochynska","year":"2016","journal-title":"J. Mater. Sci. Mater. M."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1177\/0885328218763912","article-title":"Synthesis of a novel biomedical poly(ester urethane) based on aliphatic uniform-size diisocyanate and the blood compatibility of PEG-grafted surfaces","volume":"32","author":"Liu","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, L., Gao, Y., Zhao, J., Yuan, L., Li, C., Liu, Z., and Hou, Z. (2018). A mild method for surface-grafting PEG onto segmented poly(ester-urethane) film with high grafting density for biomedical purpose. Polymers, 10.","DOI":"10.3390\/polym10101125"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.msec.2013.03.007","article-title":"Grafting of phosphorylcholine functional groups on polycarbonate urethane surface for resisting platelet adhesion","volume":"33","author":"Gao","year":"2013","journal-title":"Mat. Sci. Eng. C"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1016\/j.polymer.2004.02.072","article-title":"Effects of solid substrate on structure and properties of casting waterborne polyurethane\/carboxymethylchitin films","volume":"45","author":"Zeng","year":"2004","journal-title":"Polymer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10973-016-5388-8","article-title":"Synthesis and characterization of biodegradable copoly(ether-ester-urethane)s and their chitin whisker nanocomposites","volume":"125","author":"Mohamed","year":"2016","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s10965-018-1614-3","article-title":"Preparation, physicochemical properties and biocompatibility of biodegradable poly(ether-ester-urethane) and chitosan oligosaccharide composites","volume":"25","author":"Zhang","year":"2018","journal-title":"J. Polym. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11426-012-4759-7","article-title":"Improved biocompatibility of phosphorylcholine end-capped poly(butylene succinate)","volume":"56","author":"Zhang","year":"2013","journal-title":"Sci. China Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1002\/jbm.a.34967","article-title":"Surface reconstruction and hemo-compatibility improvement of a phosphorylcholine end-capped poly(butylene succinate) coating","volume":"102","author":"Hao","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1295\/polymj.22.355","article-title":"Preparation of phospholipid polylners and their properties as polymer hydrogel membranes","volume":"22","author":"Ishihara","year":"1990","journal-title":"Polym. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0142-9612(84)90047-4","article-title":"Biomembrane surfaces as models for polymer design: The potential for haemocompatibility","volume":"5","author":"Hayward","year":"1984","journal-title":"Biomaterials"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0142-9612(01)00104-1","article-title":"Synthesis, characterization and platelet adhesion of segmented polyurethanes grafted phospholipid analogous vinyl monomer on surface","volume":"23","author":"Korematsu","year":"2002","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1080\/09205063.2014.920172","article-title":"Durable modification of segmented polyurethane for elastic blood-contacting devices by graft-type 2-methacryloyloxyethyl phosphorylcholine copolymer","volume":"25","author":"Liu","year":"2014","journal-title":"J. Biomater. Sci. Polym. E"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/1099-1581(200008\/12)11:8\/12<626::AID-PAT13>3.0.CO;2-G","article-title":"Biocompatible elastomers composed of segmented polyurethane and 2-methacryloyloxyethyl phosphorylcholine polymer","volume":"11","author":"Ishihara","year":"2000","journal-title":"Polym. Adv. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.biomaterials.2009.01.013","article-title":"A small diameter, fibrous vascular conduit generated from a poly (ester urethane) urea and phospholipid polymer blend","volume":"30","author":"Hong","year":"2009","journal-title":"Biomaterials"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1016\/S0142-9612(03)00450-2","article-title":"Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications","volume":"24","author":"Ho","year":"2003","journal-title":"Biomaterials"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/(SICI)1097-4636(199611)32:3<391::AID-JBM12>3.0.CO;2-K","article-title":"Improved blood compatibility of segmented polyurethanes by polymeric additives having phospholipid polar groups. I. Molecular design of polymeric additives and their functions","volume":"32","author":"Ishihara","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0142-9612(95)94150-J","article-title":"Synthesis of phospholipid polymers having a urethane bond in the side chain as coating material on segmented polyurethane and their platelet adhesion-resistant properties","volume":"16","author":"Ishihara","year":"1995","journal-title":"Biomaterials"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.msec.2016.05.026","article-title":"Protein adsorption capability on polyurethane and modified-polyurethane membrane for periodontal guided tissue regeneration applications","volume":"68","author":"Sheikh","year":"2016","journal-title":"Mat. Sci. Eng. C"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3390\/polym2030102","article-title":"Polyurethane membranes modified with isopropyl myristate as a potential candidate for encapsulating electronic implants: A study of biocompatibility and water permeability","volume":"2","author":"Roohpour","year":"2010","journal-title":"Polymers"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.colsurfb.2005.11.019","article-title":"Effect of conjugated linoleic acid immobilization on the hemocompatibility of cellulose acetate membrane","volume":"47","author":"Kung","year":"2006","journal-title":"Colloid. Surface. B"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/pat.1466","article-title":"Swelling and biocompatibility of sodium alginate\/poly(\u03b3-glutamic acid) hydrogels","volume":"21","author":"Huang","year":"2010","journal-title":"Polym. Adv. Technol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.actbio.2008.02.016","article-title":"Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties","volume":"4","author":"Caracciolo","year":"2008","journal-title":"Acta Biomater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/09205063.2016.1252303","article-title":"Preparation and properties of biomedical segmented polyurethanes based on poly(ether ester) and uniform-size diurethane diisocyanates","volume":"28","author":"Yin","year":"2007","journal-title":"J. Biomat. Sci. Polym. E"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/adv.20254","article-title":"Effects of polyvinylpyrrolidone on structure and performance of composite scaffold of chitosan superfine powder and polyurethane","volume":"31","author":"Zuo","year":"2012","journal-title":"Adv. Polym. Tech."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.colsurfb.2018.01.005","article-title":"Anticoagulant polyurethane substrates modified with poly(2-methacryloyloxyethyl phosphorylcholine) via SI-RATRP","volume":"163","author":"Chi","year":"2018","journal-title":"Colloid. Surface. B"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijpharm.2007.01.016","article-title":"Long acting porous microparticle for pulmonary protein delivery","volume":"333","author":"Kwon","year":"2007","journal-title":"Int. J. Pharmaceut."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1080\/09205063.2013.873282","article-title":"Effects of molecular architecture of phospholipid polymers on surface modification of segmented polyurethanes","volume":"25","author":"Liu","year":"2014","journal-title":"J. Biomat. Sci. Polym. E"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/am800260t","article-title":"Self-initiated surface graft polymerization of 2-methacryloyloxyrthyl phosphorylcholine on poly(ether ether ketone) by photoirradiation","volume":"1","author":"Kyomoto","year":"2009","journal-title":"Acs. Appl. Mater. Inter."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.actbio.2016.11.005","article-title":"Hemocompatibility studies on a degradable polar hydrophobic ionic polyurethane (D-PHI)","volume":"48","author":"Brockman","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jbm.a.31418","article-title":"Group reorientation and migration of amphiphilic polymer bearing phosphorylcholine functionalities on surface of cellular membrane mimicking coating","volume":"84","author":"Yang","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"15350","DOI":"10.1021\/ja0457314","article-title":"Phosphoryl choline introduces dual activity in biomimetic ionomers","volume":"126","author":"Nederberg","year":"2004","journal-title":"J. Am. Chem. Soc."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/11\/5\/860\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:51:10Z","timestamp":1760187070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/11\/5\/860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,11]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["polym11050860"],"URL":"https:\/\/doi.org\/10.3390\/polym11050860","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,11]]}}}