{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:44:21Z","timestamp":1781541861795,"version":"3.54.5"},"reference-count":90,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Due to their elastomeric behavior, polyurethane-based scaffolds can find various applications in soft-tissue engineering. However, their relatively inert surface has to be modified in order to improve cell colonization and control cell fate. The present study focuses on porous biodegradable scaffolds based on poly(ester-urea-urethane), functionalized concomitantly to the scaffold elaboration with low-molecular-weight (LMW) fucoidan; and their bio-activation with platelet rich plasma (PRP) formulations with the aim to promote cell response. The LMW fucoidan-functionalization was obtained in a very homogeneous way, and was stable after the scaffold sterilization and incubation in phosphate-buffered saline. Biomolecules from PRP readily penetrated into the functionalized scaffold, leading to a biological frame on the pore walls. Preliminary in vitro assays were assessed to demonstrate the improvement of scaffold behavior towards cell response. The scaffold bio-activation drastically improved cell migration. Moreover, cells interacted with all pore sides into the bio-activated scaffold forming cell bridges across pores. Our work brought out an easy and versatile way of developing functionalized and bio-activated elastomeric poly(ester-urea-urethane) scaffolds with a better cell response.<\/jats:p>","DOI":"10.3390\/polym11061016","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T03:16:51Z","timestamp":1560136611000},"page":"1016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Use of Platelet-Rich Plasma to Promote Cell Recruitment into Low-Molecular-Weight Fucoidan-Functionalized Poly(Ester-Urea-Urethane) Scaffolds for Soft-Tissue Engineering"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-3476","authenticated-orcid":false,"given":"G\u00e9raldine","family":"Rohman","sequence":"first","affiliation":[{"name":"Tissue Engineering and Proteomics (TIP) team, CSPBAT UMR CNRS 7244, Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, 74 rue Marcel Cachin, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Credson","family":"Langueh","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Proteomics (TIP) team, CSPBAT UMR CNRS 7244, Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, 74 rue Marcel Cachin, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-7584","authenticated-orcid":false,"given":"Salah","family":"Ramtani","sequence":"additional","affiliation":[{"name":"LBPS team, CSPBAT UMR CNRS 7244, Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, 99 avenue Jean-Baptiste Cl\u00e9ment, 93430 Villetaneuse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Lataillade","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Unit\u00e9 de Th\u00e9rapie Cellulaire et R\u00e9paration Tissulaire, Site du Centre de Transfusion Sanguine des Arm\u00e9es \u201cJean Julliard\u201d de Clamart, BP 73, 91223 Br\u00e9tigny-sur-Orge Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lutomski","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Proteomics (TIP) team, CSPBAT UMR CNRS 7244, Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, 74 rue Marcel Cachin, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Senni","sequence":"additional","affiliation":[{"name":"Ecole de biologie Industrielle, 49 avenue des Genottes, 95885 Cergy Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-6729","authenticated-orcid":false,"given":"Sylvie","family":"Changotade","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Proteomics (TIP) team, CSPBAT UMR CNRS 7244, Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, 74 rue Marcel Cachin, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.22203\/eCM.v005a03","article-title":"Making Tissue Engineering Scaffolds Work. 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