{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:58:19Z","timestamp":1768402699447,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Functionalization of tetrapropylcalix[4]resorcinarene, tetrapentylcalix[4]resorcinarene, tetranonylcalix[4]resorcinarene, and tetra-(4-hydroxyphenyl)calix[4]resorcinarene by means of aminomethylation reactions with the amino acids \u03b2-alanine and l-proline in the presence of aqueous formaldehyde was carried out. When \u03b2-alanine was used, the reaction products were tetrabenzoxazines. The reaction with tetra-(4-hydroxyphenyl)calix[4]resorcinarene did not proceed under the experimental conditions; therefore, l-proline was used, and the corresponding tetra-Mannich base was regio- and diasteroselectively formed. The products were characterized via FT-IR, 1H NMR, 13C NMR, and elemental analysis. With these aminomethylated-calix[4]resorcinarenes, the chemical surface modification of the copolymers poly(GMA\u2013co\u2013EDMA) and poly(BMA\u2013co\u2013EDMA\u2013co\u2013MMA) in a basic medium was studied. The results were quite satisfactory, obtaining the corresponding copolymers functionalized by nucleophilic substitution reaction and ring-opening between the carboxyl group of the upper rim of aliphatic calix[4]resorcinarenes and the hydroxyl group of the lower rim in the aromatic calix[4]resorcinarene and the epoxy group of the glycidyl methacrylate residue of each copolymer. The modified copolymers were characterized via FT-IR, scanning electron microscopy imaging, and elemental analysis. Finally, the modified copolymer surfaces exhibited interaction with peptides, showing their potential application in chromatographic separation techniques such as high-performance liquid chromatography.<\/jats:p>","DOI":"10.3390\/polym11071147","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:13:18Z","timestamp":1562238798000},"page":"1147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Aminomethylated Calix[4]resorcinarenes as Modifying Agents for Glycidyl Methacrylate (GMA) Rigid Copolymers Surface"],"prefix":"10.3390","volume":"11","author":[{"given":"Betty Astrid","family":"Vel\u00e1squez-Silva","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogot\u00e1, Carrera 30 No. 45-03, 7122 Carrera, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-109X","authenticated-orcid":false,"given":"Alver","family":"Castillo-Aguirre","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogot\u00e1, Carrera 30 No. 45-03, 7122 Carrera, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-8488","authenticated-orcid":false,"given":"Zuly Jenny","family":"Rivera-Monroy","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogot\u00e1, Carrera 30 No. 45-03, 7122 Carrera, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogot\u00e1, Carrera 30 No. 45-03, 7122 Carrera, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/chromatography2010079","article-title":"Recent Advances and Uses of Monolithic Columns for the Analysis of Residues and Contaminants in Food","volume":"2","author":"Barreiro","year":"2015","journal-title":"Chromatography"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.trac.2015.08.015","article-title":"Solid-phase extraction of organic compounds: A critical review (Part I)","volume":"80","author":"Canle","year":"2016","journal-title":"Trends Anal. 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