{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:00:46Z","timestamp":1768010446862,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Chronic wounds are severe breaks in the skin barrier that fail to heal in an acceptable time-frame, thus preventing the complete restoration of the tissue\u2019s anatomical and functional integrity, increasing the likelihood of infections and apoptosis. Hydrogels are known as a drug delivery system and have the potential to cover wounds and burns on the skin. Aloe barbadensis contains over 75 different bioactive compounds which are responsible for its anti-inflammatory and antimicrobial properties. In this study, the polyacrylamide-co-methylcellulose hydrogel containing Aloe barbadensis were developed. The extract was prepared from lyophilized Aloe barbadensis, using methanolic extraction, characterized by high performance liquid chromatography and incorporated into the hydrogels. These Aloe barbadensis hydrogels were characterized by degree of swelling, Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermal profiling using thermogravimetric analysis. The minimum inhibitory concentration test was done on the Aloe barbadensis extract to evaluate its antibacterial and antifungal activity in vitro. The Aloe barbadensis hydrogels and were shown to swell to almost 2000% of their original sizes. The Fourier-transform infrared spectroscopy indicated the presence of bands characteristic of Aloe barbadensis and hydrogel polymers. The basic hydrogel showed greater thermal stability than the hydrogels with Aloe barbadensis. The minimum inhibitory concentration showed inhibition of the growth of S. aureus and Salmonella spp. at specific concentrations. The hydrogel therefore presents itself as an excellent potential curative cover of cutaneous lesions.<\/jats:p>","DOI":"10.3390\/polym12030690","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T07:29:07Z","timestamp":1584689347000},"page":"690","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Polyacrylamide-Metilcellulose Hydrogels Containing Aloe barbadensis Extract as Dressing for Treatment of Chronic Cutaneous Skin Lesions"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-9044","authenticated-orcid":false,"given":"Desire\u00e9","family":"Alesa Gyles","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0470-6532","authenticated-orcid":false,"given":"Anivaldo Duarte","family":"Pereira J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Diniz Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical and Cosmetic R&amp;D, College of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa","family":"Santa Brigida","sequence":"additional","affiliation":[{"name":"Laboratory of Chromatography and Mass Spectrometry, Faculty of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Louze","family":"Nobre Lamar\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-8245","authenticated-orcid":false,"given":"Wagner Luiz","family":"Ramos Barbosa","sequence":"additional","affiliation":[{"name":"Laboratory of Chromatography and Mass Spectrometry, Faculty of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-1039","authenticated-orcid":false,"given":"Jos\u00e9 Ot\u00e1vio","family":"Carr\u00e9ra Silva J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical and Cosmetic R&amp;D, College of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-0617","authenticated-orcid":false,"given":"Roseane Maria","family":"Ribeiro-Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ribeiro, D.M.L., Carvalho, A.R., de Macedo, V., Rodrigues, G.H., Chagas, V.L., Silva, L.d.S., Cutrim, B.d.S., Santos , D.M., Soares, B.L.L., and da Albuquerque, P.B.S. (2019). Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials. Biomolecules, 10.","DOI":"10.3390\/biom10010063"},{"key":"ref_2","first-page":"e19","article-title":"Evidence-based management strategies for treatment of chronic wounds","volume":"9","author":"Werdin","year":"2009","journal-title":"Eplasty"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","article-title":"Human skin wounds: A major and snowballing threat to public health and the economy","volume":"17","author":"Sen","year":"2009","journal-title":"Wound Repair Regen."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"38S","DOI":"10.1016\/S0002-9610(03)00303-9","article-title":"A specialized wound-healing center concept: Importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds","volume":"187","author":"Gottrup","year":"2004","journal-title":"Am. J. Surg."},{"key":"ref_5","first-page":"49","article-title":"The Roles of Physical Therapists in Wound Management, Part II: Patient and Wound Evaluation","volume":"1","author":"Kloth","year":"2009","journal-title":"J. Am. Col. Certif. Wound Spec."},{"key":"ref_6","first-page":"92","article-title":"Global initiative for wound and lymphoedema care (GIWLC)","volume":"4","author":"MacDonald","year":"2009","journal-title":"J. Lymphoedema"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000348331","article-title":"Effectiveness of advanced versus conventional wound dressings on healing of chronic wounds: Systematic review and meta-analysis","volume":"226","author":"Heyer","year":"2013","journal-title":"Dermatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.12927\/hcq.2014.23787","article-title":"Compromised wounds in Canada","volume":"17","author":"Denny","year":"2014","journal-title":"Health Q."},{"key":"ref_9","first-page":"44","article-title":"The burden of chronic wounds in the UK","volume":"104","author":"Posnett","year":"2008","journal-title":"Nurs. Times"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_11","unstructured":"Ministry of Health\/Anvisa\/Fiocruz (2005). Protocol for the Prevention of Pressure Ulcer\u2014Annex 02, Registered Nurses\u2019 Association of Ontario. Revised."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kusuma, S., Shen, Y., Hanjaya-Putra, D., Mali, P., Cheng, L., and Gerecht, S. (2013). Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix. Proc. Natl. Acad. Sci. USA, 110.","DOI":"10.1073\/pnas.1306562110"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.eurpolymj.2008.12.017","article-title":"Frontal polymerization as a new method for developing drug controlled release systems (DCRS) based on polyacrylamide","volume":"45","author":"Gavini","year":"2009","journal-title":"Eur. Polym. J."},{"key":"ref_14","unstructured":"Gulrez, S., Al-Assaf, S., and Phillips, G. (2011). Hydrogels: Methods of Preparation. Charact. Appl."},{"key":"ref_15","unstructured":"Nilimanka, D. (2013). Preparation methods and properties of hydrogel: A review. Int. J. Pharm. Pharm. Sci., 5."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/am300292v","article-title":"Flexible and Microporous Chitosan Hydrogel\/Nano Zno Composite Bandages for Wound Dressing: In Vitro and In Vivo Evaluation","volume":"4","author":"Kumar","year":"2012","journal-title":"ACS Appl. Mater Interfaces"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Aouada, F., Moura, M., Menezes, E., Nogueira, A., and Mattoso, L. (2008). Synthesis of hydrogels and release kinetics of ammonium and potassium. Soil. Sci., 1643\u20131649.","DOI":"10.1590\/S0100-06832008000400029"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.physb.2006.12.080","article-title":"QENS study on thermal gelation in aqueous solution of methylcellulose","volume":"393","author":"Yamamuro","year":"2007","journal-title":"Phys. B Condens. Matter"},{"key":"ref_19","first-page":"S3","article-title":"Comparison of the Effect of Aloe Vera Gel And Nitrofurazone 2% On Epithelialization And Granulation Tissue Formation Regarding Superficial Second-Degree Burns","volume":"41","author":"Irani","year":"2016","journal-title":"Iran. J. Med Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijbiomac.2020.01.076","article-title":"An investigation of the inhibitory mechanism of \u03b1-glucosidase by chysalodin from Aloe vera","volume":"147","author":"Kim","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_21","first-page":"1","article-title":"Aloe barbadensis\u2014A Legendary Medicinal Plant","volume":"15","author":"Juneby","year":"2009","journal-title":"Pharmacognosy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/0019-5154.44785","article-title":"Aloe Vera: A Short Review","volume":"53","author":"Surjushe","year":"2008","journal-title":"Indian J. Dermatology Pmc. Web."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3390\/molecules13081599","article-title":"Composition and Applications of Aloe Vera Leaf Gel","volume":"13","author":"Hamman","year":"2008","journal-title":"Molecules"},{"key":"ref_24","first-page":"1","article-title":"Aloe Vera Gel Research Review: An Overview of Its Clinical Uses and Proposed Mechanisms of Action","volume":"4","author":"Grundmann","year":"2012","journal-title":"Nat. Med. J."},{"key":"ref_25","first-page":"1","article-title":"The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds. Hindawi Publishing Corporation","volume":"2015","author":"Hashemi","year":"2015","journal-title":"Biol. Med. Res. Int."},{"key":"ref_26","first-page":"420","article-title":"Quantitative Estimation of Barbaloin in Aloe Vera and Its Commercial Formulations by Using HPLC","volume":"2","author":"Pandey","year":"2012","journal-title":"Int. J. Med. Aromat. Plants"},{"key":"ref_27","first-page":"34","article-title":"A two year study monitoring some chemical and physical characteristics of field grown Aloe barbadensis Leaves","volume":"47","author":"Wang","year":"1995","journal-title":"Subtrop. Plant Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Azaroual, L., Liazid, A., Barbero, G.F., Brigul, J., Palma, M., and Barroso, C.G. (2012). Improved Chromatographic Methods For determination of bioactive compounds from Aloe Vera Leaves. Int. Sch. Res. Netw.","DOI":"10.5402\/2012\/609095"},{"key":"ref_29","unstructured":"(2010). Farmacopeia Brasileira, Atheneu Publisher. [5th ed.]."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.carbpol.2009.10.021","article-title":"Synthesis and swelling behavior of acrylatedstarch-g-poly (acrylic acid) and acrylatedstarch-g-poly (acrylamide) hydrogels","volume":"79","author":"Pourjavadi","year":"2010","journal-title":"Carbohydrate Polym."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/app.30339","article-title":"Removal of paraquat pesticide from aqueous solutions using a novel adsorbent material based on polyacrylamide and methylcellulose hydrogels","volume":"114","author":"Aouada","year":"2009","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1016\/j.biomaterials.2009.01.040","article-title":"Silk fibroin\/Polyacrylamide Semi-Interpenetrating Network Hydrogels for Controlled Drug Release","volume":"30","author":"Mandal","year":"2009","journal-title":"Biomaterials"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.polymertesting.2005.11.005","article-title":"Electrochemical And Mechanical Properties Of Hydrogels Based On Conductive Poly(3,4-Ethylene Dioxythiophene)\/Poly(Styrenesulfonate) And PAAm","volume":"25","author":"Aouada","year":"2006","journal-title":"Polym. Test."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.carbpol.2007.01.020","article-title":"Synthesis, Characterization and Swelling Studies of Ph Responsive Psyllium And Methacrylamide Based Hydrogels For The Use In Colon Specific Drug Delivery","volume":"69","author":"Singh","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.carbpol.2006.06.015","article-title":"Rheological characterization of a novel thermosensitive chitosan\/Poly(Vinyl Alcohol) Blend Hydrogel","volume":"67","author":"Tang","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep09598","article-title":"Thermal degradation of sucralose: A combination of analytical methods to determine stability and chlorinated by products","volume":"5","author":"Oliveira","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_37","first-page":"1975","article-title":"Antimicrobial activity of different Aloe barbadensis Mill. and Aloe arborescens Mill. leaf fractions","volume":"6","author":"Pellizzoni","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s12010-009-8577-0","article-title":"Antibacterial activities of crude extract of Aloe barbadensis to clinically isolated bacterial pathogens","volume":"160","author":"Pandey","year":"2010","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1128\/JCM.00921-13","article-title":"Influence of Clinical Breakpoint Changes From CLSI 2009 To EUCAST 2011 Antimicrobial Susceptibility Testing Guidelines On Multidrug Resistance Rates Of Gram-Negative Rods","volume":"51","author":"Hombach","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"ref_40","first-page":"95","article-title":"Antibacterial, antioxidant and enzyme inhibition activity capacities of Doronicum macrolepis (FREYN&SINT): An endemic plant from Turkey","volume":"28","year":"2019","journal-title":"Saudi Pharmaceutical Journal."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1590\/S0074-02762002000700017","article-title":"Screening of Some Plants Used In The Brazilian Folk Medicine For The Treatment Of Infectious Diseases","volume":"97","author":"Holetz","year":"2002","journal-title":"Mem Inst Oswaldo Cruz Rio De Jan."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chang, L., Yan, C., Fuwei, P., Yuliang, C., Yahui, G., and He, Q. (2019). Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review. Molecules, 24.","DOI":"10.3390\/molecules24081554"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.0909-752X.2006.00155.x","article-title":"Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques","volume":"12","author":"Gaspar","year":"2006","journal-title":"Skin Res. Technol."},{"key":"ref_44","first-page":"31","article-title":"A Review on Pharmacological Properties of Aloe vera International","volume":"29","author":"Priyanka","year":"2014","journal-title":"J. Pharm. Sci. Rev. Res."},{"key":"ref_45","first-page":"1","article-title":"The Effect of Aloe vera (Linn) On Cutaneous Wound Healing and Wound Contraction Rate in Adult Rabbits","volume":"5","author":"Attah","year":"2016","journal-title":"Nova J. Med Biol. Sci."},{"key":"ref_46","first-page":"2421","article-title":"Extraction and preliminary analysis of Aloin obtained from Aloe barbadensis Miller","volume":"23","author":"Nagaraju","year":"2011","journal-title":"Asian J. Chem."},{"key":"ref_47","first-page":"251","article-title":"An HPLC Procedure for the Quantification of Aloin in Latex and Gel from Aloe barbadensis Leaves","volume":"55","year":"2016","journal-title":"J. Chromatogr. Sci"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4236\/ajac.2013.410071","article-title":"Quantitative Detection of Aloin and Related Compounds Present in Herbal Products and Aloe Vera Plant Extract Using HPLC Method","volume":"4","author":"Logaranjan","year":"2013","journal-title":"Am. J. Anal. Chem."},{"key":"ref_49","unstructured":"Garrett, R.H., and Grisham, C.M. (2005). Biochemistry, Thomson. [3rd ed.]."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s10973-011-1572-z","article-title":"Thermal analysis characterization of PAAm-co-MC Hydrogels","volume":"106","author":"Tavares","year":"2011","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_51","first-page":"603","article-title":"Hydrogels: A Smart Drug Delivery System","volume":"2","author":"Sandeep","year":"2012","journal-title":"Int. J. Res. Pharm. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.eurpolymj.2005.03.020","article-title":"Optical and Morphological Characterization of Polyacrylamide Hydrogel and Liquid Crystal Systems","volume":"41","author":"Aouada","year":"2005","journal-title":"Eur. Polym. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s10973-011-2088-2","article-title":"Investigation of thermal behavior of Heliotropium indicum L. lyophilized extract by TG and DSC","volume":"111","year":"2013","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1543-1150(03)00005-X","article-title":"A review on the relationship of Aloe Vera components and their biologic effects","volume":"1","author":"Choi","year":"2003","journal-title":"Semin. Integr. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"683","DOI":"10.12968\/jowc.2019.28.10.683","article-title":"Nutrition in wound healing: Investigation of the molecular mechanisms, a narrative review","volume":"28","author":"Palmieri","year":"2019","journal-title":"J. Wound Care"},{"key":"ref_56","unstructured":"Pawar, S.G., and Kamble V., M. (2015). Quantitative Assessment of Mineral Composition of Aloe vera (L.) Burm.f. leaves by ICP-MS and CHNS Analyzer. Int. J. Sci. Res., 4."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.fbp.2009.06.001","article-title":"Effect of Temperature on structural properties of Aloe vera (Aloe barbadensis Miller) gel and Weibull distribution for modelling drying process","volume":"88","author":"Miranda","year":"2010","journal-title":"Food Bioprod. Process."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.3390\/polym6092332","article-title":"Preparation and Characterization of ZnS, CdS and HgS\/Poly(methyl methacrylate) Nanocomposites","volume":"6","author":"Mbese","year":"2014","journal-title":"Polymers"},{"key":"ref_59","first-page":"2229","article-title":"Development of Flexible Low Dielectric Constant Polyimide Films Based on Iso-Propylidene, Aryl-Ether Linked Dianhydride\/Diamine","volume":"3","author":"Dhakshnamoorthy","year":"2012","journal-title":"Int. J. Sci. Eng. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","article-title":"Methods for in vitro evaluating microbial methods: A review","volume":"6","author":"Balouiri","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"ref_61","first-page":"1","article-title":"Comparative analysis of antimicrobial activity of methanolic extracts of Aloe vera and quantification of Aloe emodin collected from different climatic zones of India","volume":"6","author":"Kumar","year":"2015","journal-title":"Arch. Clin. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1468-3083.2003.00797.x","article-title":"Cutaneous Infection Caused by Salmonella typhi","volume":"7","author":"Marzano","year":"2003","journal-title":"J. Eur. Acad. Dematol. Venereol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus Aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, And Management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pastar, I., Nusbaum, A.G., Gil, J., Patel, S.B., Chen, J., Valdes, J., Stojadinovic, O., Plano, L.R., Tomic-Canic, M., and Davis, S.C. (2013). Interactions of Methicillin Resistant Staphylococcus Aureus Usa300 And Pseudomonas Aeruginosa In Polymicrobial Wound Infection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056846"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/10590500600614303","article-title":"An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera","volume":"25","author":"Boudreau","year":"2006","journal-title":"J. Environ. Sci. Health\u2014Part. C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4066\/AMJ.2012.1301","article-title":"Efficacy of fresh Aloe Vera Gel against multi-drug resistant bacteria in infected leg ulcers","volume":"5","author":"Banu","year":"2012","journal-title":"Australas. Med J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1166\/jbn.2012.1461","article-title":"Synthesis and biological evaluation of chitin hydrogel\/nano zno composite bandage as antibacterial wound dressing","volume":"8","author":"Kumar","year":"2012","journal-title":"J. Biomed Nanotechnol"},{"key":"ref_68","unstructured":"National Institute of Meterology (2019, March 05). Climate Data. INMET, Available online: http:\/\/www.inmet.gov.br\/portal\/index.php?r=home2\/index."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/12\/3\/690\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:09:50Z","timestamp":1760173790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/12\/3\/690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,19]]},"references-count":68,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["polym12030690"],"URL":"https:\/\/doi.org\/10.3390\/polym12030690","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,19]]}}}