{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:35:45Z","timestamp":1762079745505,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministerio de Econom\u00eda y Competitividad","award":["DPI2015-65401-C3-2-R"],"award-info":[{"award-number":["DPI2015-65401-C3-2-R"]}]},{"name":"Generalitat Valenciana, Conseller\u00eda de Educaci\u00f3n, Investigaci\u00f3n, Cultura y Deporte","award":["AEST\/2019\/040"],"award-info":[{"award-number":["AEST\/2019\/040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>A simple procedure has been developed to synthesize uncrosslinked soluble poly(hydroxyethyl methacrylate) (PHEMA) gels, ready for use in a subsequent fabrication stage. The presence of 75 wt % methanol (MetOH) or dimethylformamide (DMF) impedes lateral hydroxyl\u2013hydroxyl hydrogen bonds between PHEMA macromers to form during their solution polymerization at 60 \u00b0C, up to 24 h. These gels remain soluble when properly stored in closed containers under cold conditions and, when needed, yield by solvent evaporation spontaneous physically-crosslinked PHEMA adapted to the mould used. Moreover, this two-step procedure allows obtaining multicomponent systems where a stable and water-affine PHEMA network would be of interest. In particular, amphiphilic polycaprolactone (PCL):PHEMA semi-interpenetrated (sIPN) substrates have been developed, from quaternary metastable solutions in chloroform (CHCl3):MetOH 3:1 wt. and PCL ranging from 50 to 90 wt % in the polymer fraction (thus determining the composition of the solution). The coexistence of these countered molecules, uniformly distributed at the nanoscale, has proven to enhance the number and interactions of serum protein adsorbed from the acellular medium as compared to the homopolymers, the sIPN containing 80 wt % PCL showing an outstanding development. In accordance to the quaternary diagram presented, this protocol can be adapted for the development of polymer substrates, coatings or scaffolds for biomedical applications, not relying upon phase separation, such as the electrospun mats here proposed herein (12 wt % polymer solutions were used for this purpose, with PCL ranging from 50% to 100% in the polymer fraction).<\/jats:p>","DOI":"10.3390\/polym12061256","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T09:19:27Z","timestamp":1591089567000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Amphipathic Substrates Based on Crosslinker-Free Poly(\u03b5-Caprolactone):Poly(2-Hydroxyethyl Methacrylate) Semi-Interpenetrated Networks Promote Serum Protein Adsorption"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-3808","authenticated-orcid":false,"given":"Guillermo","family":"Vilari\u00f1o-Feltrer","sequence":"first","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Salgado-Gallegos","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"de-la-Concepci\u00f3n-Ausina","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-824X","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-2679","authenticated-orcid":false,"given":"Mohsen","family":"Shahrousvand","sequence":"additional","affiliation":[{"name":"Caspian Faculty of Engineering, College of Engineering, University of Tehran, P.O. Box 119-43841 Rezvanshahr, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-8666","authenticated-orcid":false,"given":"Ana","family":"Vall\u00e9s-Lluch","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"},{"name":"Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/185117a0","article-title":"Hydrophilic Gels for Biological Use","volume":"185","author":"Wichterle","year":"1960","journal-title":"Nature"},{"key":"ref_2","unstructured":"Andrade, J.D. (1976). Synthetic Hydrogels for Biomedical Applications. 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