{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:17:23Z","timestamp":1792282643329,"version":"4.4.0"},"reference-count":122,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["01R16P00718"],"award-info":[{"award-number":["01R16P00718"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.<\/jats:p>","DOI":"10.3390\/polym12071574","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T05:10:30Z","timestamp":1595394630000},"page":"1574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Magdalena","family":"Zi\u0119ba","sequence":"first","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Sk\u0142odowska St., 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Chaber","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Sk\u0142odowska St., 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadar","family":"Duale","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Sk\u0142odowska St., 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-9370","authenticated-orcid":false,"given":"Magdalena","family":"Martinka Maksymiak","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Sk\u0142odowska St., 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Basczok","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 6 Uniwersytetu Pozna\u0144skiego St., 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-7466","authenticated-orcid":false,"given":"Marek","family":"Kowalczuk","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Sk\u0142odowska St., 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-7400","authenticated-orcid":false,"given":"Grazyna","family":"Adamus","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Sk\u0142odowska St., 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100214","DOI":"10.1039\/C6RA22072J","article-title":"Development, optimization and evaluation of tinidazole functionalized electrospun poly(\u03b5-caprolactone) nanofiber membranes for the treatment of periodontitis","volume":"6","author":"Khan","year":"2016","journal-title":"RSC Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1902\/jop.2005.76.12.2187","article-title":"Strengthening the prevention of periodontal disease: The WHO approach","volume":"76","author":"Petersen","year":"2005","journal-title":"J. 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