{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:36:38Z","timestamp":1768095398619,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universitat Polit\u00e8cnica de Val\u00e8ncia, FPI-UPV grant (PAID-01-19).","award":["PAID-01-19"],"award-info":[{"award-number":["PAID-01-19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>We aimed to study the distribution of hydroxyapatite (HA) and halloysite nanotubes (HNTs) as fillers and their influence on the hydrophobic character of conventional polymers used in the biomedical field. The hydrophobic polyester poly (\u03b5-caprolactone) (PCL) was blended with its more hydrophilic counterpart poly (lactic acid) (PLA) and the hydrophilic acrylate poly (2-hydroxyethyl methacrylate) (PHEMA) was analogously compared to poly (ethyl methacrylate) (PEMA) and its copolymer. The addition of HA and HNTs clearly improve surface wettability in neat samples (PCL and PHEMA), but not that of the corresponding binary blends. Energy-dispersive X-ray spectroscopy mapping analyses show a homogenous distribution of HA with appropriate Ca\/P ratios between 1.3 and 2, even on samples that were incubated for seven days in simulated body fluid, with the exception of PHEMA, which is excessively hydrophilic to promote the deposition of salts on its surface. HNTs promote large aggregates on more hydrophilic polymers. The degradation process of the biodegradable polyester PCL blended with PLA, and the addition of HA and HNTs, provide hydrophilic units and decrease the overall crystallinity of PCL. Consequently, after 12 weeks of incubation in phosphate buffered saline the mass loss increases up to 48% and mechanical properties decrease above 60% compared with the PCL\/PLA blend.<\/jats:p>","DOI":"10.3390\/polym12081703","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T12:15:38Z","timestamp":1596111338000},"page":"1703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications"],"prefix":"10.3390","volume":"12","author":[{"given":"Elena","family":"Torres","sequence":"first","affiliation":[{"name":"Textile Industry Research Association (AITEX), Plaza Emilio Sala 1, 03801 Alcoy, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Dominguez-Candela","sequence":"additional","affiliation":[{"name":"Technological Institute of Materials (ITM), Universitat Polit\u00e8cnica de Val\u00e8ncia (UPV), Plaza Ferr\u00e1ndiz y Carbonell 1, 03801 Alcoy, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-652X","authenticated-orcid":false,"given":"Sergio","family":"Castello-Palacios","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia (UPV), Cam\u00ed de Vera s\/n, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-8666","authenticated-orcid":false,"given":"Anna","family":"Vall\u00e9s-Lluch","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia (UPV), Cam\u00ed de Vera s\/n, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-6205","authenticated-orcid":false,"given":"Vicent","family":"Fombuena","sequence":"additional","affiliation":[{"name":"Technological Institute of Materials (ITM), Universitat Polit\u00e8cnica de Val\u00e8ncia (UPV), Plaza Ferr\u00e1ndiz y Carbonell 1, 03801 Alcoy, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2320\/matertrans.M2011358","article-title":"Bone Loss and Reduced Bone Quality of the Human Femur after Total Hip Arthroplasty under Stress-Shielding Effects by Titanium-Based Implant","volume":"53","author":"Noyama","year":"2012","journal-title":"Mater. 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