{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:12:07Z","timestamp":1784121127231,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sistema General de Regal\u00edas\u2013FCTeI-Colombia","award":["BPIN: 2013000100300"],"award-info":[{"award-number":["BPIN: 2013000100300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Bacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents in acrylic bone cements (ABCs) is open. In this study, the antibacterial effect of formulations of ABCs loaded with graphene oxide (GO) between 0 and 0.5 wt.% was evaluated against Gram-positive bacteria: Bacillus cereus and Staphylococcus aureus, and Gram-negative ones: Salmonella enterica and Escherichia coli. It was found that the effect of GO was dependent on the concentration and type of bacteria: GO loadings \u22650.2 wt.% presented total inhibition of Gram-negative bacteria, while GO loadings \u22650.3 wt.% was necessary to achieve the same effect with Gram-positives bacteria. Additionally, the evaluation of some physical and mechanical properties showed that the presence of GO in cement formulations increased wettability by 17%, reduced maximum temperature during polymerization by 19%, increased setting time by 40%, and increased compressive and flexural mechanical properties by up to 17%, all of which are desirable behaviors in ABCs. The formulation of ABC loading with 0.3 wt.% GO showed great potential for use as a bone cement with antibacterial properties.<\/jats:p>","DOI":"10.3390\/polym12081773","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T07:25:03Z","timestamp":1597044303000},"page":"1773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-2045","authenticated-orcid":false,"given":"Mayra Eliana Valencia","family":"Zapata","sequence":"first","affiliation":[{"name":"Grupo de Materiales Compuestos, Escuela de Ingenier\u00eda de Materiales, Universidad del Valle, Calle 13 #, Cali 100-00, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Marcela","family":"Ruiz Rojas","sequence":"additional","affiliation":[{"name":"Grupo de Materiales Compuestos, Escuela de Ingenier\u00eda de Materiales, Universidad del Valle, Calle 13 #, Cali 100-00, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-4431","authenticated-orcid":false,"given":"Jos\u00e9 Herminsul","family":"Mina Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Grupo de Materiales Compuestos, Escuela de Ingenier\u00eda de Materiales, Universidad del Valle, Calle 13 #, Cali 100-00, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-4741","authenticated-orcid":false,"given":"Johannes","family":"Delgado-Ospina","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Biotecnolog\u00eda, Facultad de Ingenier\u00eda, Universidad de San Buenaventura Cali, Carrera 122 # 6-65, Cali 76001, Colombia"},{"name":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-4571","authenticated-orcid":false,"given":"Carlos David Grande","family":"Tovar","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n de Fotoqu\u00edmica y Fotobiolog\u00eda, Universidad del Atl\u00e1ntico, Carrera 30 N\u00famero 8-49, Puerto Colombia 081008, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Eil Bakhtiari, S.S., Bakhsheshi-Rad, H.R., Karbasi, S., Tavakoli, M., Razzaghi, M., Fauzi Ismail, A., Ramakrishna, S., and Berto, F. (2020). Polymethyl Methacrylate-Based Bone Cements Containing Carbon Nanotubes and Graphene Oxide: An Overview of Physical, Mechanical, and Biological Properties. 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