{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:30:47Z","timestamp":1790029847554,"version":"4.0.1"},"reference-count":47,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310917\/2014-0"],"award-info":[{"award-number":["310917\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro, FAPERJ","award":["E-26\/201.304\/2014"],"award-info":[{"award-number":["E-26\/201.304\/2014"]}]},{"name":"Centre National de la Recherche Scientifique, CNRS","award":["PICS project Biointerfaces #272116"],"award-info":[{"award-number":["PICS project Biointerfaces #272116"]}]},{"name":"PVE fellowship program","award":["#406407\/2013-4"],"award-info":[{"award-number":["#406407\/2013-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Poly(lactic-co-glycolic acid) (PLGA) has been used in the field of tissue engineering as a scaffold due to its good biocompatibility, biodegradability and mechanical strength. With the aim to explore the degradability of PLGA electrospun nonwoven structures for oral mucosa tissue engineering applications, non-irradiated and gamma irradiated nonwovens were immersed in three different solutions, in which simulated body fluid (SBF) and artificial saliva are important for future oral mucosa tissue engineering. The nonwovens were immersed for 7, 15 and 30 days in SBF, culture media (DMEM) and artificial saliva at 37 \u00b0C. Before immersion in the solutions, the dosage of 15 kGy was applied for sterilization in one assay and compared with non-irradiated samples at the same timepoints. Samples were characterized using different techniques such as scanning electron microscopy (SEM), differential scanning calorimetric (DSC) and gel permeation chromatography (GPC) to evaluate the nonwoven degradation and Fourier-transform infrared spectroscopy (FTIR) to evaluate the chain scissions. Our results showed that PLGA nonwovens were constituted by semicrystalline fibers with moderate degradation properties up to thirty days. The non-irradiated samples exhibited slower kinetics of degradation than irradiated nonwovens. For immersion times longer than 7 days in the three different solutions, the mean diameter of irradiated fibers stayed in the same range, but significantly different from the control sample. On non-irradiated samples, the degradation kinetics was slower and the plateau in the diameter value was only attained after 30 days of immersion in the fluids. Plasticization (fluid absorption into the fiber structure) occurred in the bulk material, as confirmed by a decrease in Tg observed by DSC analyses of non-irradiated and irradiated nonwovens, in comparison with the respective controls. In addition, artificial saliva showed a higher capacity of influencing PLGA crystallization than SBF and DMEM. FTIR analyses showed typical PLGA chemical functional groups changes. These results will be important for future application of those PLGA electrospun nonwovens for oral mucosa regeneration.<\/jats:p>","DOI":"10.3390\/polym12081853","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T11:15:27Z","timestamp":1597749327000},"page":"1853","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["In Vitro Degradation of Electrospun Poly(Lactic-Co-Glycolic Acid) (PLGA) for Oral Mucosa Regeneration"],"prefix":"10.3390","volume":"12","author":[{"given":"Ana","family":"Chor","sequence":"first","affiliation":[{"name":"Biomineralization Laboratory, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-4663","authenticated-orcid":false,"given":"Raquel Pires","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Macromolecules Professor Eloisa Mano, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Machado","family":"Costa","sequence":"additional","affiliation":[{"name":"Biomineralization Laboratory, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Farina","sequence":"additional","affiliation":[{"name":"Biomineralization Laboratory, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Ponche","sequence":"additional","affiliation":[{"name":"The Mulhouse Materials Science Institute (IS2M), CNRS, University of Haute-Alsace, CNRS, UMR 7361, F-68100 Mulhouse, France"},{"name":"University of Strasbourg, F-67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lys","family":"Sirelli","sequence":"additional","affiliation":[{"name":"Institute of Macromolecules Professor Eloisa Mano, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautier","family":"Schrodj","sequence":"additional","affiliation":[{"name":"The Mulhouse Materials Science Institute (IS2M), CNRS, University of Haute-Alsace, CNRS, UMR 7361, F-68100 Mulhouse, France"},{"name":"University of Strasbourg, F-67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gree","sequence":"additional","affiliation":[{"name":"The Mulhouse Materials Science Institute (IS2M), CNRS, University of Haute-Alsace, CNRS, UMR 7361, F-68100 Mulhouse, France"},{"name":"University of Strasbourg, F-67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Rodrigues de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Biomineralization Laboratory, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-205X","authenticated-orcid":false,"given":"Karine","family":"Anselme","sequence":"additional","affiliation":[{"name":"The Mulhouse Materials Science Institute (IS2M), CNRS, University of Haute-Alsace, CNRS, UMR 7361, F-68100 Mulhouse, France"},{"name":"University of Strasbourg, F-67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1891-7530","authenticated-orcid":false,"given":"Marcos Lopes","family":"Dias","sequence":"additional","affiliation":[{"name":"Institute of Macromolecules Professor Eloisa Mano, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1582-4934.2006.tb00421.x","article-title":"The history of tissue engineering","volume":"10","author":"Vacanti","year":"2006","journal-title":"J. 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