{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:55:12Z","timestamp":1760234112625,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019286","name":"Ajman University","doi-asserted-by":"publisher","award":["IRG-2018-A-PH-01"],"award-info":[{"award-number":["IRG-2018-A-PH-01"]}],"id":[{"id":"10.13039\/501100019286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The non-toxic inorganic antimicrobial agents iodine (I2) and copper (Cu) are interesting alternatives for biocidal applications. Iodine is broad-spectrum antimicrobial agent but its use is overshadowed by compound instability, uncontrolled iodine release and short-term effectiveness. These disadvantages can be reduced by forming complex-stabilized, polymeric polyiodides. In a facile, in-vitro synthesis we prepared the copper-pentaiodide complex [Cu(H2O)6(12-crown-4)5]I6 \u00b7 2I2, investigated its structure and antimicrobial properties. The chemical structure of the compound has been verified. We used agar well and disc-diffusion method assays against nine microbial reference strains in comparison to common antibiotics. The stable complex revealed excellent inhibition zones against C. albicans WDCM 00054, and strong antibacterial activities against several pathogens. [Cu(H2O)6(12-crown-4)5]I6 \u00b7 2I2 is a strong antimicrobial agent with an interesting crystal structure consisting of complexes located on an inversion center and surrounded by six 12-crown-4 molecules forming a cationic substructure. The six 12-crown-4 molecules form hydrogen bonds with the central Cu(H2O)6. The anionic substructure is a halogen bonded polymer which is formed by formal I5\u2212 repetition units. The topology of this chain-type polyiodide is unique. The I5\u2212 repetition units can be understood as a triodide anion connected to two iodine molecules.<\/jats:p>","DOI":"10.3390\/polym13071005","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T21:36:51Z","timestamp":1616621811000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antimicrobial Hexaaquacopper(II) Complexes with Novel Polyiodide Chains"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-3473","authenticated-orcid":false,"given":"Zehra","family":"Edis","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Science, Ajman University, PO Box 346, Ajman, United Arab Emirates"},{"name":"Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Raheja","sequence":"additional","affiliation":[{"name":"SVKM\u2019S Dr. Bhanuben Nanavati College of Pharmacy, Mumbai 400056, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9450-2252","authenticated-orcid":false,"given":"Samir Haj","family":"Bloukh","sequence":"additional","affiliation":[{"name":"Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates"},{"name":"Department of Clinical Sciences, College of Pharmacy and Health Science, Ajman University, PO Box 346, Ajman, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richie R.","family":"Bhandare","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Science, Ajman University, PO Box 346, Ajman, United Arab Emirates"},{"name":"Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Abu","family":"Sara","sequence":"additional","affiliation":[{"name":"Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates"},{"name":"Department of Clinical Sciences, College of Pharmacy and Health Science, Ajman University, PO Box 346, Ajman, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido J.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Institut fur Anorganische Chemie und Strukturchemie, Heinrich-Heine University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. 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