{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:37:06Z","timestamp":1791596226700,"version":"4.3.4"},"reference-count":57,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xunta de Galicia pre-doctoral grant","award":["ED481A 2019\/314"],"award-info":[{"award-number":["ED481A 2019\/314"]}]},{"name":"BLUEHUMAN project","award":["EAPA_151\/2016, Atlantic Area 2016"],"award-info":[{"award-number":["EAPA_151\/2016, Atlantic Area 2016"]}]},{"name":"BLUEBIOLAB project","award":["POCTEP INTERREG Espa\u00f1a-Portugal"],"award-info":[{"award-number":["POCTEP INTERREG Espa\u00f1a-Portugal"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>How sterilization techniques accurately affect the properties of biopolymers continues to be an issue of discussion in the field of biomedical engineering, particularly now with the development of 3D-printed devices. One of the most widely used biopolymers in the manufacture of biomedical devices is the polylactic acid (PLA). Despite the large number of studies found in the literature on PLA devices, relatively few papers focus on the effects of sterilization treatments on its properties. It is well documented in the literature that conventional sterilization techniques, such as heat, gamma irradiation and ethylene oxide, can induced damages, alterations or toxic products release, due to the thermal and hydrolytical sensitivity of PLA. The purposes of this paper are, therefore, to review the published data on the most common techniques used to sterilize PLA medical devices and to analyse how they are affecting their physicochemical and biocompatible properties. Emerging and alternative sterilization methods for sensitive biomaterials are also presented.<\/jats:p>","DOI":"10.3390\/polym13132115","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T13:39:22Z","timestamp":1624887562000},"page":"2115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["How to Sterilize Polylactic Acid Based Medical Devices?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-3847","authenticated-orcid":false,"given":"Sara","family":"P\u00e9rez Davila","sequence":"first","affiliation":[{"name":"New Materials Group, Campus Lagoas-Marcosende, CINTECX, Universidade de Vigo, 36310 Vigo, Spain"},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gonz\u00e1lez Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"New Materials Group, Campus Lagoas-Marcosende, CINTECX, Universidade de Vigo, 36310 Vigo, Spain"},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Chiussi","sequence":"additional","affiliation":[{"name":"New Materials Group, Campus Lagoas-Marcosende, CINTECX, Universidade de Vigo, 36310 Vigo, Spain"},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-4025","authenticated-orcid":false,"given":"Julia","family":"Serra","sequence":"additional","affiliation":[{"name":"New Materials Group, Campus Lagoas-Marcosende, CINTECX, Universidade de Vigo, 36310 Vigo, Spain"},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00edo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"New Materials Group, Campus Lagoas-Marcosende, CINTECX, Universidade de Vigo, 36310 Vigo, Spain"},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lerouge, S., and Simmons, A. 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