{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:19:49Z","timestamp":1790277589461,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 \u00b1 20 nm, a polydispersity index of 0.238 \u00b1 0.001, a zeta potential of +19.0 \u00b1 0.9 mV, a pH of 5.7 \u00b1 0.06, and a spherical shape. Thermal and infrared spectroscopy confirmed nanocomposite generation. PG-PN pharmacokinetics was studied after a single oral dose in male Wistar rats. PG-PN showed greater distribution and clearance than free PG. The antinociceptive effect of PG-PN in neuropathic pain rats was tested by using the chronic constriction injury model. The parameter investigated was the mechanical nociceptive threshold measured by the von Frey filaments test; PG-PN showed a longer antinociceptive effect than free PG. The rota-rod and barbiturate sleep induction procedures were used to determine adverse effects; the criteria included motor deficit and sedative effects. PG-PN and free PG had plenty of motors. PG-PN exhibited a less sedative effect than free PG. By prolonging the antinociceptive effect and decreasing the unfavorable effects, polymeric nanocomposites with pregabalin have shown promise in treating neuropathic pain.<\/jats:p>","DOI":"10.3390\/polym13213837","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:42:54Z","timestamp":1636317774000},"page":"3837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain"],"prefix":"10.3390","volume":"13","author":[{"given":"Rafaela Figueiredo","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Barbosa","family":"Nunes","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias M\u00e9dicas, Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-3678","authenticated-orcid":false,"given":"Sandra Barbosa Neder","family":"Agostini","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma Freitas","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Cancino-Bernardi","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-422X","authenticated-orcid":false,"given":"Rodrigo Vicentino","family":"Placido","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamyris Reis","family":"Moraes","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Motricidade, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 37133-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Tavares Jacon","family":"Freitas","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Ribeiro","family":"Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-539X","authenticated-orcid":false,"given":"Fl\u00e1via Chiva","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovane","family":"Galdino","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Motricidade, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 37133-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-0350","authenticated-orcid":false,"given":"Vanessa Bergamin","family":"Boralli","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 371300-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2007.08.033","article-title":"Pharmacologic management of neuropathic pain: Evidence-based recommendations","volume":"132","author":"Dworkin","year":"2007","journal-title":"Pain"},{"key":"ref_2","unstructured":"Food and Drug Administration (FDA) (2021, February 01). 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