{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:24:46Z","timestamp":1773487486064,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA.<\/jats:p>","DOI":"10.3390\/polym13244426","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T21:32:40Z","timestamp":1639690360000},"page":"4426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biocompatible Hydrogel for Intra-Articular Implantation Comprising Cationic and Anionic Polymers of Natural Origin: In Vivo Evaluation in a Rabbit Model"],"prefix":"10.3390","volume":"13","author":[{"given":"Karina L.","family":"Bierbrauer","sequence":"first","affiliation":[{"name":"Centro de Excelencia en Productos y Procesos de C\u00f3rdoba, Gobierno de la Provincia de C\u00f3rdoba, Pabell\u00f3n CEPROCOR, Santa Maria de Punilla, C\u00f3rdoba CP 5164, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana V.","family":"Alasino","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Productos y Procesos de C\u00f3rdoba, Gobierno de la Provincia de C\u00f3rdoba, Pabell\u00f3n CEPROCOR, Santa Maria de Punilla, C\u00f3rdoba CP 5164, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando E.","family":"Barclay","sequence":"additional","affiliation":[{"name":"Instituto Argentino de Diagn\u00f3stico y Tratamiento SA (IADT) en Ortopedia y Traumatolog\u00eda, Cirug\u00eda Artrosc\u00f3pica y Medicina del Deporte, Marcelo T. de Alvear 2346\/2400, Buenos Aires C1122AAL, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo M.","family":"Belotti","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina"},{"name":"Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL), Esperanza 3080, Argentina"},{"name":"Facultad de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral (UNL), Esperanza 3080, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-3133","authenticated-orcid":false,"given":"Hugo H.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina"},{"name":"Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL), Esperanza 3080, Argentina"},{"name":"Facultad de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral (UNL), Esperanza 3080, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dante M.","family":"Beltramo","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Productos y Procesos de C\u00f3rdoba, Gobierno de la Provincia de C\u00f3rdoba, Pabell\u00f3n CEPROCOR, Santa Maria de Punilla, C\u00f3rdoba CP 5164, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","first-page":"152","article-title":"The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee","volume":"107","author":"Michael","year":"2010","journal-title":"Dtsch. 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